{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:53:48Z","timestamp":1784159628961,"version":"3.55.0"},"reference-count":26,"publisher":"China Science Publishing & Media Ltd.","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8197102014"],"award-info":[{"award-number":["8197102014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["333 project, BRA 2017153"],"award-info":[{"award-number":["333 project, BRA 2017153"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2021,3,1]]},"DOI":"10.1093\/abbs\/gmab038","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T12:08:38Z","timestamp":1616155718000},"page":"697-706","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2\/STAT3 signaling pathway in gastric cancer"],"prefix":"10.3724","volume":"53","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daorong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"null","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/hel.12339","volume":"21","author":"Venerito M","year":"2016","unstructured":"Venerito M, Link A, Rokkas T, Malfertheiner P. Gastric cancer-clinical and epidemiological aspects. Helicobacter, 2016, 21: 39-44.","journal-title":"Helicobacter"},{"key":"null","doi-asserted-by":"publisher","first-page":"621","DOI":"10.11622\/smedj.2014174","volume":"55","author":"Ang TL","year":"2014","unstructured":"Ang TL, Fock KM. Clinical epidemiology of gastric cancer. Singapore Med J, 2014, 55: 621-628.","journal-title":"Singapore Med J"},{"key":"null","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"Ferlay J","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136: E359-E386.","journal-title":"Int J Cancer"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317714626","volume":"39","author":"Song Z","year":"2017","unstructured":"Song Z, Wu Y, Yang J, Yang D, Fang X. Progress in the treatment of advanced gastric cancer. Tumor Biol, 2017, 39:","journal-title":"Tumor Biol"},{"key":"null","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cam4.1274","volume":"7","author":"Charalampakis N","year":"2018","unstructured":"Charalampakis N, Economopoulou P, Kotsantis I, Tolia M, Schizas D, Liakakos T, Elimova E. Medical management of gastric cancer: a 2017 update. Cancer Med, 2018, 7: 123-133.","journal-title":"Cancer Med"},{"key":"null","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.mcn.2015.06.009","volume":"67","author":"Kapuralin K","year":"2015","unstructured":"Kapuralin K, \u0106urlin M, Mitre\u010di\u0107 D, Kosi N, Schwarzer C, Glavan G, Gajovi\u0107 S. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Mol Cell Neurosci, 2015, 67: 104-115.","journal-title":"Mol Cell Neurosci"},{"key":"null","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1046\/j.1365-2443.2000.00303.x","volume":"5","author":"Takata H","year":"2000","unstructured":"Takata H, Kato M, Denda K, Kitamura N. A Hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. Genes Cells, 2000, 5: 57-69.","journal-title":"Genes Cells"},{"key":"null","first-page":"16","volume":"47","author":"Curlin M","year":"2006","unstructured":"Curlin M, Lucic V, Gajovic S. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional exon with stop codon within region coding for VHS domain. Croat Med J, 2006, 47: 16-24.","journal-title":"Croat Med J"},{"key":"null","volume":"34","author":"D\u017eombeta T","year":"2014","unstructured":"D\u017eombeta T, Kapuralin K, Ulamec M, Tomas D, Gajovi\u0107 S, Kru\u0161lin B. Immunohistochemical expression of STAM2 in gastrointestinal stromal tumors. Anticancer Res, 2014, 34:","journal-title":"Anticancer Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/ar.21522","volume":"295","author":"Kapuralin K","year":"2012","unstructured":"Kapuralin K, Van Ginneken C, Curlin M, Timmermans J, Gajovic S. Neurons and a subset of interstitial cells of Cajal in the enteric nervous system highly express Stam2 gene. Anat Rec, 2012, 295: 113-120.","journal-title":"Anat Rec"},{"key":"null","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0014-5793(00)01760-9","volume":"477","author":"Endo K","year":"2000","unstructured":"Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K. STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett, 2000, 477: 55-61.","journal-title":"FEBS Lett"},{"key":"null","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0014-5793(01)03079-4","volume":"508","author":"Lohi O","year":"2001","unstructured":"Lohi O, Lehto V. STAM\/EAST\/Hbp adapter proteins\u2013integrators of signalling pathways. FEBS Lett, 2001, 508: 287-290.","journal-title":"FEBS Lett"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0927-1","volume":"20","author":"Pillai SG","year":"2018","unstructured":"Pillai SG, Li S, Siddappa CM, Ellis MJ, Watson MA, Aft R. Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient-derived xenograft mouse model. Breast Cancer Res, 2018, 20:","journal-title":"Breast Cancer Res"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0847-5","volume":"19","author":"Xu X","year":"2019","unstructured":"Xu X, Gao F, Wang J, Long C, Chen X, Tao L, Yang L. BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK\/STAT3 signaling pathway. Cancer Cell Int, 2019, 19:","journal-title":"Cancer Cell Int"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105751","volume":"123","author":"Liang W","year":"2020","unstructured":"Liang W, Xia B, He C, Zhai G, Li M, Zhou J. Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase\/signal transducer and activator of transcription signalling pathway. Int J Biochem Cell Biol, 2020, 123:","journal-title":"Int J Biochem Cell Biol"},{"key":"null","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1158\/0008-5472.CAN-09-2468","volume":"70","author":"Lin L","year":"2010","unstructured":"Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res, 2010, 70: 2445-2454.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/jb\/mvh046","volume":"135","author":"Mizuno E","year":"2004","unstructured":"Mizuno E. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. J Biochem, 2004, 135: 385-396.","journal-title":"J Biochem"},{"key":"null","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S1074-7613(00)80288-5","volume":"6","author":"Takeshita T","year":"1997","unstructured":"Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Immunity, 1997, 6: 449-457.","journal-title":"Immunity"},{"key":"null","doi-asserted-by":"publisher","first-page":"7915","DOI":"10.1007\/s13277-015-3509-9","volume":"36","author":"Kaymaz BT","year":"2015","unstructured":"Kaymaz BT, G\u00fcnel NS, Ceyhan M, \u00c7etinta\u015f VB, \u00d6zel B, Yand\u0131m MK, K\u0131p\u00e7ak S. Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted \u201chsa-miR-2278\u201d as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. Tumor Biol, 2015, 36: 7915-7927.","journal-title":"Tumor Biol"},{"key":"null","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s10495-014-1030-z","volume":"19","author":"Hu Y","year":"2014","unstructured":"Hu Y, Hong Y, Xu Y, Liu P, Guo D, Chen Y. Inhibition of the JAK\/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC. Apoptosis, 2014, 19: 1627-1636.","journal-title":"Apoptosis"},{"key":"null","doi-asserted-by":"publisher","first-page":"15941","DOI":"10.1002\/jcb.28871","volume":"120","author":"Wang S","year":"2019","unstructured":"Wang S, Zhang S, He Y, Huang X, Hui Y, Tang Y. HOXA11-AS regulates JAK-STAT pathway by miR-15a-3p\/STAT3 axis to promote the growth and metastasis in liver cancer. J Cell Biochem, 2019, 120: 15941-15951.","journal-title":"J Cell Biochem"},{"key":"null","volume":"38","author":"Jiang L","year":"2019","unstructured":"Jiang L, Zhao X, Mao Y, Wang J, Zheng H, You Q. Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK\/STAT signaling pathway by targeting STAT5 and STAT6. J Eep Clin Cancer Res, 2019, 38:","journal-title":"J Eep Clin Cancer Res"},{"key":"null","volume":"9","author":"Ouyang J","year":"2017","unstructured":"Ouyang J, Pan X, Lin H, Hu Z, Xiao P, Hu H. GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK\/STAT signaling pathway. Am J Transl Res, 2017, 9:","journal-title":"Am J Transl Res"},{"key":"null","doi-asserted-by":"publisher","first-page":"38633","DOI":"10.1074\/jbc.M007849200","volume":"275","author":"Pandey A","year":"2000","unstructured":"Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. J Biol Chem, 2000, 275: 38633-38639.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061451","volume":"9","author":"Bose S","year":"2020","unstructured":"Bose S, Banerjee S, Mondal A, Chakraborty U, Pumarol J, Croley CR, Bishayee A. Targeting the JAK\/STAT signaling pathway using phytocompounds for cancer prevention and therapy. Cells, 2020, 9:","journal-title":"Cells"},{"key":"null","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11122002","volume":"11","author":"Owen KL","year":"2019","unstructured":"Owen KL, Brockwell KN, Parker BS. JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression. Cancers, 2019, 11:","journal-title":"Cancers"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/D8F66708877C4EB186002FE1869D4812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab038","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/abbs\/article-pdf\/53\/6\/697\/38274539\/gmab038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/D8F66708877C4EB186002FE1869D4812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T10:32:29Z","timestamp":1659004349000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3,29]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmab038","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}