{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:52:02Z","timestamp":1785426722525,"version":"3.56.0"},"reference-count":43,"publisher":"China Science Publishing & Media Ltd.","issue":"10","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key R&D projects of Sichuan Science and Technology Department","award":["2019YFS0531"],"award-info":[{"award-number":["2019YFS0531"]}]},{"name":"Sichuan Province Science and Technology Projects","award":["2021YFH0148"],"award-info":[{"award-number":["2021YFH0148"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["2019LZXNYDJ30"],"award-info":[{"award-number":["2019LZXNYDJ30"]}]},{"name":"Sichuan Science and Technology Grant for Overseas Students","award":["19059"],"award-info":[{"award-number":["19059"]}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2021,8,1]]},"DOI":"10.1093\/abbs\/gmab103","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T19:08:16Z","timestamp":1626548896000},"page":"1277-1289","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Small-molecule inhibitor LF3 restrains the development of pulmonary hypertension through the Wnt\/&amp;beta;-catenin pathway"],"prefix":"10.3724","volume":"53","author":[{"given":"Yong","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3892\/ol.2017.5566","volume":"13","author":"Tang Q","year":"2013","unstructured":"Tang Q, Zhao H, Yang B, Li L, Shi Q, Jiang C, Liu H. WIF-1 gene inhibition and Wnt signal transduction pathway activation in NSCLC tumorigenesis. Oncol Lett, 2013, 13: 1183-1188.","journal-title":"Oncol Lett"},{"key":"null","first-page":"904","volume":"53","author":"Luo X","year":"2018","unstructured":"Luo X, Ye S, Jiang Q, Gong Y, Yuan Y, Hu X, Su X. Wnt inhibitory factor-1-mediated autophagy inhibits Wnt\/beta-catenin signaling by downregulating dishevelled-2 expression in non-small cell lung cancer cells. Int J Oncol, 2018, 53: 904-914.","journal-title":"Int J Oncol"},{"key":"null","first-page":"6929","volume":"7","author":"Yang YR","year":"2014","unstructured":"Yang YR, Zang SZ, Zhong CL, Li YX, Zhao SS, Feng XJ. Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer. Int J Clin Exp Pathol, 2014, 7: 6929-6935.","journal-title":"Int J Clin Exp Pathol"},{"key":"null","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.healun.2015.12.004","volume":"35","author":"van der Feen DE","year":"2016","unstructured":"van der Feen DE, Dickinson MG, Bartelds B, Borgdorff MA, Sietsma H, L\u00e9vy M, Berger RM. Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension. J Heart Lung Transplant, 2016, 35: 481-490.","journal-title":"J Heart Lung Transplant"},{"key":"null","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1165\/rcmb.2019-0135ED","volume":"61","author":"Agrawal V","year":"2019","unstructured":"Agrawal V, Hemnes AR. CD44 and xCT: the silver bullet for endothelial-to-mesenchymal transition in pulmonary arterial hypertension?. Am J Respir Cell Mol Biol, 2019, 61: 281-283.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1111\/jcmm.13912","volume":"22","author":"Huang L","year":"2018","unstructured":"Huang L, Li L, Yang T, Li W, Song L, Meng X, Gu Q. Transgelin as a potential target in the reversibility of pulmonary arterial hypertension secondary to congenital heart disease. J Cell Mol Med, 2018, 22: 6249-6261.","journal-title":"J Cell Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"Nusse R","year":"2017","unstructured":"Nusse R, Clevers H. Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities. Cell, 2017, 169: 985-999.","journal-title":"Cell"},{"key":"null","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104517","volume":"150","author":"Sakunrangsit N","year":"2019","unstructured":"Sakunrangsit N, Ketchart W. Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt\/\u03b2-catenin pathway in endocrine resistant breast cancer. Pharmacol Res, 2019, 150:","journal-title":"Pharmacol Res"},{"key":"null","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12203-8","volume":"10","author":"Bernkopf DB","year":"2019","unstructured":"Bernkopf DB, Br\u00fcckner M, Hadjihannas MV, Behrens J. An aggregon in conductin\/axin2 regulates Wnt\/\u03b2-catenin signaling and holds potential for cancer therapy. Nat Commun, 2019, 10:","journal-title":"Nat Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1172\/JCI38079","volume":"119","author":"Cohen ED","year":"2009","unstructured":"Cohen ED, Ihida-Stansbury K, Lu MM, Panettieri RA, Jones PL, Morrisey EE. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C\/PDGFR pathway. J Clin Invest, 2009, 119: 2538-2549.","journal-title":"J Clin Invest"},{"key":"null","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.bbamcr.2017.06.018","volume":"1864","author":"Sankhe S","year":"2017","unstructured":"Sankhe S, Manousakidi S, Antigny F, Ataam JA, Bentebbal S, Ruchon Y, Lecerf F. T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A\/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension. Biochim Biophys Acta Mol Cell Res, 2017, 1864: 1631-1641.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00109-016-1426-z","volume":"94","author":"Wu D","year":"2016","unstructured":"Wu D, Talbot CC, Liu Q, Jing ZC, Damico RL, Tuder R, Barnes KC. Identifying microRNAs targeting Wnt\/\u03b2-catenin pathway in end-stage idiopathic pulmonary arterial hypertension. J Mol Med (Berl), 2016, 94: 875-885.","journal-title":"J Mol Med (Berl)"},{"key":"null","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI23203","volume":"115","author":"McMurtry MS","year":"2005","unstructured":"McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest, 2005, 115: 1479-1491.","journal-title":"J Clin Invest"},{"key":"null","volume":"38","author":"Li J","year":"2019","unstructured":"Li J, Yang R, Dong Y, Chen M, Wang Y, Wang G. Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the \u03b2-catenin\/TCF4 pathway through SPRY2. J Exp Clin Cancer Res, 2019, 38:","journal-title":"J Exp Clin Cancer Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2019.08.007","volume":"135","author":"Zhao L","year":"2019","unstructured":"Zhao L, Sun L, Lu Y, Li F, Xu H. A small-molecule LF3 abrogates \u03b2-catenin\/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes. J Mol Cell Cardiol, 2019, 135: 90-96.","journal-title":"J Mol Cell Cardiol"},{"key":"null","volume":"50","author":"Kim JY","year":"2018","unstructured":"Kim JY, Lee JS, Hwang HS, Lee DR, Park CY, Jung SJ, You YR. Wnt signal activation induces midbrain specification through direct binding of the beta-catenin\/TCF4 complex to the EN1 promoter in human pluripotent stem cells. Exp Mol Med, 2018, 50:","journal-title":"Exp Mol Med"},{"key":"null","first-page":"3431","volume":"18","author":"Jia XX","year":"2019","unstructured":"Jia XX, Zhu TT, Huang Y, Zeng XX, Zhang H, Zhang WX. Wnt\/beta-catenin signaling pathway regulates asthma airway remodeling by influencing the expression of c-Myc and cyclin D1 via the p38 MAPK-dependent pathway. Exp Ther Med, 2019, 18: 3431-3438.","journal-title":"Exp Ther Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtn.2018.10.012","volume":"14","author":"Yang C","year":"2019","unstructured":"Yang C, Yao C, Tian R, Zhu Z, Zhao L, Li P, Chen H. miR-202-3p regulates sertoli cell proliferation, synthesis function, and apoptosis by targeting LRP6 and cyclin D1 of Wnt\/\u03b2-catenin signaling. Mol Ther Nucleic Acids, 2019, 14: 1-19.","journal-title":"Mol Ther Nucleic Acids"},{"key":"null","volume":"8","author":"Lee WS","year":"2013","unstructured":"Lee WS, Woo EY, Kwon J, Park MJ, Lee JS, Han YH, Bae IH. Bcl-w enhances mesenchymal changes and invasiveness of glioblastoma cells by inducing nuclear accumulation of \u03b2-Catenin. PLoS One, 2013, 8:","journal-title":"PLoS One"},{"key":"null","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/0008-5472.CAN-15-1519","volume":"76","author":"Fang L","year":"2016","unstructured":"Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, Von Kries JP. A small-molecule antagonist of the \u03b2-catenin\/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Res, 2016, 76: 891-901.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2016.04.003","volume":"96","author":"Wang N","year":"2016","unstructured":"Wang N, Huo R, Cai B, Lu Y, Ye B, Li X, Li F. Activation of Wnt\/\u03b2-catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression. Free Radic Biol Med, 2016, 96: 34-44.","journal-title":"Free Radic Biol Med"},{"key":"null","doi-asserted-by":"crossref","DOI":"10.1177\/2045894019889775","volume":"9","author":"Spiekerkoetter E","year":"2019","unstructured":"Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N. Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure. Pulm Circ, 2019, 9:","journal-title":"Pulm Circ"},{"key":"null","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/bi201428h","volume":"51","author":"Tian W","year":"2012","unstructured":"Tian W, Han X, Yan M, Xu Y, Duggineni S, Lin N, Luo G. Structure-based discovery of a novel inhibitor targeting the \u03b2-catenin\/Tcf4 interaction. Biochemistry, 2012, 51: 724-731.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/abbs\/gmz161","volume":"52","author":"Gong H","year":"2020","unstructured":"Gong H, Gao S, Yu C, Li M, Liu P, Zhang G, Song J. Effect and mechanism of YB-1 knockdown on glioma cell growth, migration, and apoptosis. Acta Biochim Biophys Sin, 2020, 52: 168-179.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10799893.2020.1738482","volume":"40","author":"Chen J","year":"2020","unstructured":"Chen J, Zhang H, Yu W, Chen L, Wang Z, Zhang T. Expression of pulmonary arterial elastin in rats with hypoxic pulmonary hypertension using H2S. J Recept Signal Transduct Res, 2020, 40: 383-387.","journal-title":"J Recept Signal Transduct Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"L1273","DOI":"10.1152\/ajplung.00082.2012","volume":"302","author":"Wei L","year":"2012","unstructured":"Wei L, Warburton RR, Preston IR, Roberts KE, Comhair SA, Erzurum SC, Hill NS. Serotonylated fibronectin is elevated in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 2012, 302: L1273-L1279.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s12551-019-00584-5","volume":"11","author":"Ridone P","year":"2019","unstructured":"Ridone P, Vassalli M, Martinac B. Piezo1 mechanosensitive channels: what are they and why are they important. Biophys Rev, 2019, 11: 795-805.","journal-title":"Biophys Rev"},{"key":"null","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1002\/jcb.26729","volume":"119","author":"Cong LH","year":"2018","unstructured":"Cong LH, Du SY, Wu YN, Liu Y, Li T, Wang H, Li G. Upregulation of Klotho potentially inhibits pulmonary vascular remodeling by blocking the activation of the Wnt signaling pathway in rats with PM2.5-induced pulmonary arterial hypertension. J Cell Biochem, 2018, 119: 5581-5597.","journal-title":"J Cell Biochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/pr.2013.42","volume":"73","author":"Alapati D","year":"2013","unstructured":"Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S. Inhibition of LRP5\/6-mediated Wnt\/\u03b2-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats. Pediatr Res, 2013, 73: 719-725.","journal-title":"Pediatr Res"},{"key":"null","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13139-9","volume":"10","author":"Arnold ND","year":"2019","unstructured":"Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nat Commun, 2019, 10:","journal-title":"Nat Commun"},{"key":"null","first-page":"4984","volume":"20","author":"Cai C","year":"2019","unstructured":"Cai C, Xiang Y, Wu Y, Zhu N, Zhao H, Xu J, Lin W. Formononetin attenuates monocrotaline induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats. Mol Med Rep, 2019, 20: 4984-4992.","journal-title":"Mol Med Rep"},{"key":"null","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/ped.12684","volume":"57","author":"Kawakami S","year":"2015","unstructured":"Kawakami S, Minamisawa S. Oxygenation decreases elastin secretion from rat ductus arteriosus smooth muscle cells. Pediatr Int, 2015, 57: 541-545.","journal-title":"Pediatr Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1165\/rcmb.2010-0078OC","volume":"44","author":"Liu Y","year":"2011","unstructured":"Liu Y, Wei L, Laskin DL, Fanburg BL. Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol, 2011, 44: 548-555.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1007\/s00018-019-03150-0","volume":"76","author":"Prestel A","year":"2019","unstructured":"Prestel A, Wichmann N, Martins JM, Marabini R, Kassem N, Broendum SS, Otterlei M. The PCNA interaction motifs revisited: thinking outside the PIP-box. Cell Mol Life Sci, 2019, 76: 4923-4943.","journal-title":"Cell Mol Life Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1074\/jbc.M113.520429","volume":"289","author":"Inoue A","year":"2014","unstructured":"Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M. A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem, 2014, 289: 7109-7120.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41374-018-0103-y","volume":"99","author":"Datla SR","year":"2019","unstructured":"Datla SR, Hilenski LL, Seidel-Rogol B, Dikalova AE, Harousseau M, Punkova L, Joseph G. Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21. Lab Invest, 2019, 99: 387-398.","journal-title":"Lab Invest"},{"key":"null","first-page":"103","volume":"22","author":"Luo Y","year":"2006","unstructured":"Luo Y, Li ZC, Zhang Q, Zhang B, Liu Y, Peng LJ, Song ZJ. Different expression and significance of VEGF and PCNA in aorta and pulmonary artery smooth muscle cells of rats with hypoxia pulmonary hypertension. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2006, 22: 103-105.","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"null","volume":"12","author":"Moldoveanu T","year":"2019","unstructured":"Moldoveanu T, Czabotar PE. BAX, BAK, and BOK: a coming of age for the BCL-2 family effector proteins. Cold Spring Harb Perspect Biol, 2019, 12:","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"null","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103329","volume":"93","author":"Ahagh MH","year":"2019","unstructured":"Ahagh MH, Dehghan G, Mehdipour M, Teimuri-Mofrad R, Payami E, Sheibani N, Ghaffari M. Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: increased Bax\/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line. Bioorg Chem, 2019, 93:","journal-title":"Bioorg Chem"},{"key":"null","volume":"226","author":"Liu S","year":"2019","unstructured":"Liu S, Zhu Y, Yan S, Xiao H, Yi J, Li R, Wu J. Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G2\/M phase arrest and mitochondria-mediated Bax\/Bcl-2 pathway. Comp Biochem Physiol C Toxicol Pharmacol, 2019, 226:","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00280-009-1232-1","volume":"66","author":"Ackler S","year":"2010","unstructured":"Ackler S, Mitten MJ, Foster K, Oleksijew A, Refici M, Tahir SK, Xiao Y. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother Pharmacol, 2010, 66: 869-880.","journal-title":"Cancer Chemother Pharmacol"},{"key":"null","first-page":"394","volume":"16","author":"Lu JY","year":"2004","unstructured":"Lu JY, Yao W, Qian GS, Yang XJ, Chen WZ, Li SP. Role of bcl-2 and bax expression in apoptosis of hypoxic pulmonary artery smooth muscle cells of rats induced by Na+\/H+ exchanger isoform-1 inhibition in vitro. Zhongguo Weizhong Bing Ji Jiu Yi Xue, 2004, 16: 394-398.","journal-title":"Zhongguo Weizhong Bing Ji Jiu Yi Xue"},{"key":"null","doi-asserted-by":"crossref","first-page":"L216","DOI":"10.1152\/ajplung.00538.2017","volume":"316","author":"Wang Z","year":"2019","unstructured":"Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, Jiang Q. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 2019, 316: L216-L228.","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/37649580D9C74652BA9DA307FAE269DC","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab103","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/abbs\/article-pdf\/53\/10\/1277\/40575294\/gmab103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/37649580D9C74652BA9DA307FAE269DC","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T19:53:48Z","timestamp":1672862028000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmab103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,8,19]]},"published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmab103","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}