{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:40:06Z","timestamp":1757778006179},"reference-count":24,"publisher":"China Science Publishing & Media Ltd.","issue":"12","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2011,12,1]]},"DOI":"10.1093\/abbs\/gmr091","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T02:11:46Z","timestamp":1318299106000},"page":"948-956","update-policy":"http:\/\/dx.doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Two genes, &amp;lt;italic&amp;gt;rif15&amp;lt;\/italic&amp;gt; and &amp;lt;italic&amp;gt;rif16&amp;lt;\/italic&amp;gt;, of the rifamycin biosynthetic gene cluster in &amp;lt;italic&amp;gt;Amycolatopsis mediterranei&amp;lt;\/italic&amp;gt; likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B"],"prefix":"10.3724","volume":"43","author":[{"given":"Hua","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/cr030112j","volume":"105","author":"Floss HG","year":"2005","unstructured":"Floss HG, Yu TW. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev, 2005, 105: 621-632.","journal-title":"Chem Rev"},{"key":"null","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1126\/science.1063814","volume":"295","author":"Dye C","year":"2002","unstructured":"Dye C, Williams BG, Espinal MA, Raviglione MC. Erasing the world's slow stain: strategies to beat multidrug-resistant tuberculosis. Science, 2002, 295: 2042-2046.","journal-title":"Science"},{"key":"null","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1021\/bi010080z","volume":"40","author":"Admiraal SJ","year":"2001","unstructured":"Admiraal SJ, Walsh CT, Khosla C. The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry, 2001, 40: 6116-6123.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1021\/bi0200312","volume":"41","author":"Admiraal SJ","year":"2002","unstructured":"Admiraal SJ, Khosla C, Walsh CT. The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. Biochemistry, 2002, 41: 5313-5324.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1099\/mic.0.28138-0","volume":"151","author":"Xu J","year":"2005","unstructured":"Xu J, Wan E, Kim CJ, Floss HG, Mahmud T. Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. Microbiology, 2005, 151: 2515-2528.","journal-title":"Microbiology"},{"key":"null","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/243273a0","volume":"243","author":"White RJ","year":"1973","unstructured":"White RJ, Martinelli E, Gallo GG, Lancini G, Beynon P. Rifamycin biosynthesis studied with 13C enriched precursors and carbon magnetic resonance. Nature, 1973, 243: 273-277.","journal-title":"Nature"},{"key":"null","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1074-5521(98)90141-7","volume":"5","author":"August PR","year":"1998","unstructured":"August PR, Tang L, Yoon YJ, Ning S, Muller R, Yu TW, Taylor M. Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol, 1998, 5: 69-79.","journal-title":"Chem Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7164\/antibiotics.35.74","volume":"35","author":"Ghisalba O","year":"1982","unstructured":"Ghisalba O, Roos R, Schupp T, Nuesch J. Transformation of rifamycin S into rifamycins B and L. A revision of the current biosynthetic hypothesis. J Antibiot (Tokyo), 1982, 35: 74-80.","journal-title":"J Antibiot (Tokyo)"},{"key":"null","doi-asserted-by":"crossref","first-page":"10642","DOI":"10.1021\/ja026628m","volume":"124","author":"Guo J","year":"2002","unstructured":"Guo J, Frost JW. Kanosamine biosynthesis: a likely source of the aminoshikimate pathway's nitrogen atom. J Am Chem Soc, 2002, 124: 10642-10643.","journal-title":"J Am Chem Soc"},{"key":"null","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cbic.200400387","volume":"6","author":"Xiong Y","year":"2005","unstructured":"Xiong Y, Wu X, Mahmud T. A homologue of the Mycobacterium tuberculosis PapA5 protein, Rif-Orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Chembiochem, 2005, 6: 834-837.","journal-title":"Chembiochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0003-9861(03)00004-3","volume":"411","author":"Xu J","year":"2003","unstructured":"Xu J, Mahmud T, Floss HG. Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Arch Biochem Biophys, 2003, 411: 277-288.","journal-title":"Arch Biochem Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/cr.2010.87","volume":"20","author":"Zhao W","year":"2010","unstructured":"Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res, 2010, 20: 1096-1108.","journal-title":"Cell Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ismej.2009.58","volume":"3","author":"Penn K","year":"2009","unstructured":"Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J, 2009, 3: 1193-1203.","journal-title":"ISME J"},{"key":"null","doi-asserted-by":"crossref","first-page":"12757","DOI":"10.1021\/ja105891a","volume":"132","author":"Wilson MC","year":"2010","unstructured":"Wilson MC, Gulder TA, Mahmud T, Moore BS. Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450. J Am Chem Soc, 2010, 132: 12757-12765.","journal-title":"J Am Chem Soc"},{"key":"null","author":"Kieser T","year":"2000","journal-title":"Practical Streptomyces Genetics"},{"key":"null","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1745-7270.2006.00238.x","volume":"38","author":"Yu H","year":"2006","unstructured":"Yu H, Peng WT, Liu Y, Wu T, Yao YF, Cui MX, Jiang WH. Identification and characterization of glnA promoter and its corresponding trans-regulatory protein GlnR in the rifamycin SV producing actinomycete, Amycolatopsis mediterranei U32. Acta Biochim Biophys Sin, 2006, 38: 831-843.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1023\/A:1025698824679","volume":"25","author":"Ding X","year":"2003","unstructured":"Ding X, Tian Y, Chiao J, Zhao G, Jiang W. Stability of plasmid pA387 derivatives in Amycolatopsis mediterranei producing rifamycin. Biotechnol Lett, 2003, 25: 1647-1652.","journal-title":"Biotechnol Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nm765","volume":"8","author":"Sambandamurthy VK","year":"2002","unstructured":"Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med, 2002, 8: 1171-1174.","journal-title":"Nat Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1128\/jb.177.17.4836-4840.1995","volume":"177","author":"Beggs ML","year":"1995","unstructured":"Beggs ML, Crawford JT, Eisenach KD. Isolation and sequencing of the replication region of Mycobacterium avium plasmid pLR7. J Bacteriol, 1995, 177: 4836-4840.","journal-title":"J Bacteriol"},{"key":"null","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1039\/B604190F","volume":"24","author":"Munro AW","year":"2007","unstructured":"Munro AW, Girvan HM, McLean KJ. Variations on a (t)heme\u2013novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily. Nat Prod Rep, 2007, 24: 585-609.","journal-title":"Nat Prod Rep"},{"key":"null","doi-asserted-by":"crossref","first-page":"16844","DOI":"10.1074\/jbc.M109.092460","volume":"285","author":"Xu LH","year":"2010","unstructured":"Xu LH, Fushinobu S, Takamatsu S, Wakagi T, Ikeda H, Shoun H. Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis. J Biol Chem, 2010, 285: 16844-16853.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/ja016963v","volume":"124","author":"Guo J","year":"2002","unstructured":"Guo J, Frost JW. Biosynthesis of 1-deoxy-1-imino-D-erythrose 4-phosphate: a defining metabolite in the aminoshikimate pathway. J Am Chem Soc, 2002, 124: 528-529.","journal-title":"J Am Chem Soc"},{"key":"null","doi-asserted-by":"crossref","first-page":"12546","DOI":"10.1074\/jbc.M009667200","volume":"276","author":"Yu TW","year":"2001","unstructured":"Yu TW, Muller R, Muller M, Zhang X, Draeger G, Kim CG, Leistner E. Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in Amycolatopsis mediterranei S699. J Biol Chem, 2001, 276: 12546-12555.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"16051","DOI":"10.1074\/jbc.M007936200","volume":"276","author":"Fiedler E","year":"2001","unstructured":"Fiedler E, Golbik R, Schneider G, Tittmann K, Neef H, Konig S, Hubner G. Examination of donor substrate conversion in yeast transketolase. J Biol Chem, 2001, 276: 16051-16058.","journal-title":"J Biol Chem"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/20FCBF8AEECB46BBAF4EDE3FAED85E62","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmr091","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/20FCBF8AEECB46BBAF4EDE3FAED85E62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T10:13:27Z","timestamp":1686392007000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmr091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmr091","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}