{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:40:14Z","timestamp":1776714014413,"version":"3.51.2"},"reference-count":35,"publisher":"China Science Publishing & Media Ltd.","issue":"10","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2012,10,1]]},"DOI":"10.1093\/abbs\/gms075","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T22:29:50Z","timestamp":1348784990000},"page":"866-875","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE<sup>−\/−<\/sup> mice"],"prefix":"10.3724","volume":"44","author":[{"given":"Yideng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingkang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"e31508","DOI":"10.1371\/journal.pone.0031508","volume":"7","author":"Kennedy A","year":"2012","unstructured":"Kennedy A, Gruen ML, Gutierrez DA, Surmi BK, Orr JS, Webb CD, Hasty AH. Impact of macrophage inflammatory protein-1\u03b1 deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. PLoS One, 2012, 7:","journal-title":"PLoS One"},{"key":"null","first-page":"936109","volume":"2011","author":"Segers D","year":"2011","unstructured":"Segers D, Lipton JA, Leenen PJ, Cheng C, Tempel D, Pasterkamp G, Moll FL. Atherosclerotic plaque stability is affected by the chemokine CXCL10 in both mice and humans. Int J Inflam, 2011, 2011:","journal-title":"Int J Inflam"},{"key":"null","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.atherosclerosis.2011.08.034","volume":"219","author":"Liu W","year":"2011","unstructured":"Liu W, Redmond EM, Morrow D, Cullen JP. Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice. Atherosclerosis, 2011, 219: 448-454.","journal-title":"Atherosclerosis"},{"key":"null","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4111\/kju.2012.53.3.200","volume":"53","author":"Yoon HY","year":"2012","unstructured":"Yoon HY, Kim YW, Kang HW, Kim WT, Yun SJ, Lee SC, Kim WJ. DNA methylation of GSTP1 in human prostate tissues: pyrosequencing analysis. Korean J Urol, 2012, 53: 200-205.","journal-title":"Korean J Urol"},{"key":"null","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2217\/epi.12.2","volume":"4","author":"Felling RJ","year":"2012","unstructured":"Felling RJ, Guo JU, Song H. Neuronal activation and insight into the plasticity of DNA methylation. Epigenomics, 2012, 4: 125-127.","journal-title":"Epigenomics"},{"key":"null","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1002\/ijc.21740","volume":"118","author":"Deng G","year":"2006","unstructured":"Deng G, Nguyen A, Tanaka H, Matsuzaki K, Bell I, Mehta KR, Terdiman JP. Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer, 2006, 118: 2999-3005.","journal-title":"Int J Cancer"},{"key":"null","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2217\/epi.12.9","volume":"4","author":"Draht MX","year":"2012","unstructured":"Draht MX, Riedl RR, Niessen H, Carvalho B, Meijer GA, Herman JG, van Engeland M. Promoter CpG island methylation markers in colorectal cancer: the road ahead. Epigenomics, 2012, 4: 179-194.","journal-title":"Epigenomics"},{"key":"null","first-page":"559","author":"Hasties ND","year":"1989","unstructured":"Hasties ND, Lyon MF, Searle AG. Highly repeated DNA families in the genome of Mus. musculus. Genetic variants and strains of the laboratory mouse, 1989, 559-573.","journal-title":"Genetic variants and strains of the laboratory mouse"},{"key":"null","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1259\/bjr\/49886569","volume":"83","author":"Zhang L","year":"2010","unstructured":"Zhang L, Zhang M, Yang S, Cao Y, Zhang SB, Yin L, Tian Y. A new biodosimetric method: branched DNA-based quantitative detection of B1 DNA in mouse plasma. Br J Radiol, 2010, 83: 694-701.","journal-title":"Br J Radiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1745-7270.2007.00327.x","volume":"39","author":"Jiang Y","year":"2007","unstructured":"Jiang Y, Sun T, Xiong J, Cao J, Li G, Wang S. Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats. Acta Biochim Biophys Sin, 2007, 39: 657-667.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.bbrc.2005.08.015","volume":"335","author":"Jeong KS","year":"2005","unstructured":"Jeong KS, Lee S. Estimating the total mouse DNA methylation according to the B1 repetitive elements. Biochem Biophys Res Commun, 2005, 335: 1211-1216.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CBI20110236","volume":"36","author":"Vizirianakis IS","year":"2012","unstructured":"Vizirianakis IS, Tezias SS, Amanatiadou EP, Tsiftsoglou AS. Possible interaction between B1 retrotransposon-containing sequences and \u03b2(major) globin gene transcriptional activation during MEL cell erythroid differentiation. Cell Biol Int, 2012, 36: 47-55.","journal-title":"Cell Biol Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"e14398","DOI":"10.1371\/journal.pone.0014398","volume":"5","author":"Gallou-Kabani C","year":"2010","unstructured":"Gallou-Kabani C, Gabory A, Tost J, Karimi M, Mayeur S, Lesage J, Boudadi E. Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One, 2010, 5:","journal-title":"PLoS One"},{"key":"null","first-page":"4","volume":"51","author":"Mitroshkin MG","year":"2011","unstructured":"Mitroshkin MG, Ezhov MV, Matchin IuG, Safarova MS, Soboleva DI, Dotsenko IuV. Value of the spectral analysis of radiofrequency intravascular ultrasound data in the evaluation of nonsignificant coronary lesionsin chronic CHD patients. [Article in Russian]. Kardiologiia, 2011, 51: 4-8.","journal-title":"Kardiologiia"},{"key":"null","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/01.ATV.0000080686.39871.54","volume":"23","author":"Zulli A","year":"2003","unstructured":"Zulli A, Widdop RE, Hare DL, Buxton BF, Black MJ. High methionine and cholesterol diet abolishes endothelial relaxation. Arterioscler Thromb Vasc Biol, 2003, 23: 1358-1363.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/dna.2007.0708","volume":"27","author":"Jiang Y","year":"2008","unstructured":"Jiang Y, Liu Z, Xiong J, Cao J, Li G, Wang S. Homocysteine-mediated PPAR\u03b1,\u03b3 DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol, 2008, 27: 143-150.","journal-title":"DNA Cell Biol"},{"key":"null","first-page":"479","volume":"34","author":"Jiang Y","year":"2007","unstructured":"Jiang Y, Zhang J, Huang Y, Su J, Zhang J, Wang L, Han X. Homocysteine-mediated aberrant DNA methylation in vascular smooth muscle cells and its potential pathogenic mechanism. Prog Biochem Biophys, 2007, 34: 479-489.","journal-title":"Prog Biochem Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.atherosclerosis.2011.09.040","volume":"219","author":"Bressler J","year":"2011","unstructured":"Bressler J, Shimmin LC, Boerwinkle E, Hixson JE. Global DNA methylation and risk of subclinical atherosclerosis in young adults: the pathobiological determinants of atherosclerosis in youth (PDAY) study. Atherosclerosis, 2011, 219: 958-962.","journal-title":"Atherosclerosis"},{"key":"null","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4088\/JCP.8157su1c.04","volume":"70","author":"Papakostas GI","year":"2009","unstructured":"Papakostas GI. Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder. J Clin Psychiatry, 2009, 70: 18-22.","journal-title":"J Clin Psychiatry"},{"key":"null","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2009.12.093","volume":"392","author":"Luzhna L","year":"2010","unstructured":"Luzhna L, Kovalchuk O. Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. Biochem Biophys Res Commun, 2010, 392: 113-117.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2119\/molmed.2011.00295","volume":"18","author":"Wang H","year":"2012","unstructured":"Wang H, Wang ZH, Kong J, Yang MY, Jiang GH, Wang XP, Zhong M. Oxidized low-density lipoprotein-dependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress. Mol Med, 2012, 18: 159-166.","journal-title":"Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/dna.2007.0619","volume":"26","author":"Jiang Y","year":"2007","unstructured":"Jiang Y, Sun T, Zhang H, Xiong J, Cao J, Li G, Wang S. Folate and ApoE DNA methylation induced by homocysteine in human monocytes. DNA Cell Biol, 2007, 26: 737-744.","journal-title":"DNA Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1745-7270.2007.00291.x","volume":"39","author":"Jiang Y","year":"2007","unstructured":"Jiang Y, Zhang J, Xiong J, Cao J, Li G, Wang S. Ligands of peroxisome proliferators-activated receptor inhibit homocysteine- induced DNA methylation of inducible nitric oxide synthase gene. Acta Biochim Biophys Sin, 2007, 39: 366-376.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/cvr\/cvp182","volume":"84","author":"Feng J","year":"2009","unstructured":"Feng J, Zhang Z, Kong W, Liu B, Xu Q, Wang X. Regulatory T cells ameliorate hyperhomocysteinaemia- accelerated atherosclerosis in apoE\u2212\/\u2212 mice. Cardiovasc Res, 2009, 84: 155-163.","journal-title":"Cardiovasc Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jn\/138.2.311","volume":"138","author":"Liu C","year":"2008","unstructured":"Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H. Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr, 2008, 138: 311-315.","journal-title":"J Nutr"},{"key":"null","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4161\/epi.6.10.17728","volume":"6","author":"Cash HL","year":"2011","unstructured":"Cash HL, McGarvey ST, Houseman EA, Marsit CJ, Hawley NL, Lambert-Messerlian GM, Viali S. Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders. Epigenetics, 2011, 6: 1257-1264.","journal-title":"Epigenetics"},{"key":"null","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.nutres.2011.06.004","volume":"31","author":"Strakova J","year":"2011","unstructured":"Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine \u03b2-synthase activity and methylation capacity. Nutr Res, 2011, 31: 563-571.","journal-title":"Nutr Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1373\/49.8.1292","volume":"49","author":"Castro R","year":"2003","unstructured":"Castro R, Rivera I, Struys EA, Jansen EE, Ravasco P, Camilo ME, Blom HJ. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylationin vascular disease. Clin Chem, 2003, 49: 1292-1296.","journal-title":"Clin Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1097\/00029330-200712010-00013","volume":"120","author":"Zhang JG","year":"2007","unstructured":"Zhang JG, Liu JX, Li ZH, Wang LZ, Jiang YD, Wang SR. Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene. Chin Med J (Engl), 2007, 120: 2132-2137.","journal-title":"Chin Med J (Engl)"},{"key":"null","first-page":"691","volume":"26","author":"Castillo-D\u00edaz SA","year":"2010","unstructured":"Castillo-D\u00edaz SA, Garay-Sevilla ME, Hern\u00e1ndez-Gonz\u00e1lez MA, Sol\u00eds-Mart\u00ednez MO, Zaina S. Extensive demethylation of normally hypermethylated CpG islands occurs in human atherosclerotic arteries. Int J Mol Med, 2010, 26: 691-700.","journal-title":"Int J Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-2613.2009.00687.x","volume":"90","author":"Yu X","year":"2009","unstructured":"Yu X, Ling W, Mi M. Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine. Int J Exp Pathol, 2009, 90: 638-648.","journal-title":"Int J Exp Pathol"},{"key":"null","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1096\/fj.09-143651","volume":"24","author":"Chen NC","year":"2010","unstructured":"Chen NC, Yang F, Capecci LM, Gu Z, Schafer AI, Durante W, Yang XF. Regulation of homocysteine metabolism and methylation in human and mouse tissues. FASEB J, 2010, 24: 2804-2817.","journal-title":"FASEB J"},{"key":"null","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/toxsci\/kfj155","volume":"91","author":"Bachman AN","year":"2006","unstructured":"Bachman AN, Phillips JM, Goodman JI. Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice. Toxicol Sci, 2006, 91: 393-405.","journal-title":"Toxicol Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1089\/dna.2007.0584","volume":"26","author":"Jiang Y","year":"2007","unstructured":"Jiang Y, Zhang J, Huang Y, Su J, Zhang J, Wang S, Han X. Homocysteine-mediated expression of SAHH, DNMTs, MBD2 and DNA hypomethylation potential pathogenic mechanism in VSMCs. DNA Cell Biol, 2007, 26: 603-611.","journal-title":"DNA Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1191\/1358863x02vm418oa","volume":"7","author":"Hiltunen MO","year":"2002","unstructured":"Hiltunen MO, Turunen MP, Hakkinen TP, Rutanen J, Hedman M, Makinen K, Turunen AM. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med, 2002, 7: 5-11.","journal-title":"Vasc Med"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/32CB195AB787486684CD3A4F44D97E97","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gms075","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/32CB195AB787486684CD3A4F44D97E97","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T21:23:54Z","timestamp":1714425834000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gms075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gms075","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}