{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:13:43Z","timestamp":1787829223124,"version":"build-2784847793"},"reference-count":46,"publisher":"China Science Publishing & Media Ltd.","issue":"11","content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2013,11,1]]},"DOI":"10.1093\/abbs\/gmt099","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T07:25:36Z","timestamp":1380612336000},"page":"912-920","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Gene expression profiles of sodium-dependent vitamin C transporters in mice after alcohol consumption"],"prefix":"10.3724","volume":"45","author":[{"given":"Xiaoqiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-2004-832936","volume":"24","author":"Mandayam S","year":"2004","unstructured":"Mandayam S, Jamal MM, Morgan TR. Epidemiology of alcoholic liver disease. Semin Liver Dis, 2004, 24: 217-232.","journal-title":"Semin Liver Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","volume":"51","author":"O'Shea RS","year":"2010","unstructured":"O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology, 2010, 51: 307-328.","journal-title":"Hepatology"},{"key":"null","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0029-1214370","volume":"29","author":"Wu D","year":"2009","unstructured":"Wu D, Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis, 2009, 29: 141-154.","journal-title":"Semin Liver Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0741-8329(03)00132-0","volume":"30","author":"Purohit V","year":"2003","unstructured":"Purohit V, Russo D, Salin M. Role of iron in alcoholic liver disease: introduction and summary of the symposium. Alcohol, 2003, 30: 93-97.","journal-title":"Alcohol"},{"key":"null","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.taap.2004.06.021","volume":"202","author":"Papanikolaou G","year":"2005","unstructured":"Papanikolaou G, Pantopoulos K. Iron metabolism and toxicity. Toxicol Appl Pharmacol, 2005, 202: 199-211.","journal-title":"Toxicol Appl Pharmacol"},{"key":"null","first-page":"277","volume":"27","author":"Wu D","year":"2003","unstructured":"Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damage. Alcohol Res Health, 2003, 27: 277-284.","journal-title":"Alcohol Res Health"},{"key":"null","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","volume":"83","author":"Cederbaum AI","year":"2009","unstructured":"Cederbaum AI, Lu Y, Wu D. Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol, 2009, 83: 519-548.","journal-title":"Arch Toxicol"},{"key":"null","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0300-483X(02)00379-7","volume":"180","author":"Fraga CG","year":"2002","unstructured":"Fraga CG, Oteiza PI. Iron toxicity and antioxidant nutrients. Toxicology, 2002, 180: 23-32.","journal-title":"Toxicology"},{"key":"null","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1478-3231.2011.02604.x","volume":"31","author":"Singal AK","year":"2011","unstructured":"Singal AK, Jampana SC, Weinman SA. Antioxidants as therapeutic agents for liver disease. Liver Int, 2011, 31: 1432-1448.","journal-title":"Liver Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1211\/jpp.59.3.0015","volume":"59","author":"Saravanan N","year":"2007","unstructured":"Saravanan N, Rajasankar S, Nalini N. Antioxidant effect of 2-hydroxy-4-methoxy benzoic acid on ethanol-induced hepatotoxicity in rats. J Pharm Pharmacol, 2007, 59: 445-453.","journal-title":"J Pharm Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2174\/0929867043455567","volume":"11","author":"Kojo S","year":"2004","unstructured":"Kojo S. Vitamin C: basic metabolism and its function as an index of oxidative stress. Curr Med Chem, 2004, 11: 1041-1064.","journal-title":"Curr Med Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1089\/jmf.2009.1387","volume":"13","author":"Ambadath V","year":"2010","unstructured":"Ambadath V, Venu RG, Madambath I. Comparative study of the efficacy of ascorbic acid, quercetin, and thiamine for reversing ethanol-induced toxicity. J Med Food, 2010, 13: 1485-1489.","journal-title":"J Med Food"},{"key":"null","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/0748233710387007","volume":"27","author":"Guo X","year":"2011","unstructured":"Guo X, Li W, Xin Q, Ding H, Zhang C, Chang Y, Duan X. Vitamin C protective role for alcoholic liver disease in mice through regulating iron metabolism. Toxicol Ind Health, 2011, 27: 341-348.","journal-title":"Toxicol Ind Health"},{"key":"null","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF03174092","volume":"64","author":"Rivas CI","year":"2008","unstructured":"Rivas CI, Z\u00fa\u00f1iga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. Vitamin C transporters. J Physiol Biochem, 2008, 64: 357-375.","journal-title":"J Physiol Biochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2010.05.014","volume":"500","author":"Corti A","year":"2010","unstructured":"Corti A, Casini AF, Pompella A. Cellular pathways for transport and efflux of ascorbate and dehydroascorbate. Arch Biochem Biophys, 2010, 500: 107-115.","journal-title":"Arch Biochem Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.25.050304.092647","volume":"25","author":"Wilson JX","year":"2005","unstructured":"Wilson JX. Regulation of vitamin C transport. Annu Rev Nutr, 2005, 25: 105-125.","journal-title":"Annu Rev Nutr"},{"key":"null","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1172\/JCI39191","volume":"120","author":"Corpe CP","year":"2010","unstructured":"Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest, 2010, 120: 1069-1083.","journal-title":"J Clin Invest"},{"key":"null","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00726-007-0555-7","volume":"34","author":"Savini I","year":"2008","unstructured":"Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids, 2008, 34: 347-355.","journal-title":"Amino Acids"},{"key":"null","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.taap.2008.07.013","volume":"232","author":"Perez MJ","year":"2008","unstructured":"Perez MJ, Casta\u00f1o B, Jimenez S, Serrano MA, Gonzalez-Buitrago JM, Marin JJ. Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. Toxicol Appl Pharmacol, 2008, 232: 327-336.","journal-title":"Toxicol Appl Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.hepres.2004.02.006","volume":"29","author":"French SW","year":"2004","unstructured":"French SW. The role of hypoxia in the pathogenesis of alcoholic liver disease. Hepatol Res, 2004, 29: 69-74.","journal-title":"Hepatol Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1182\/blood-2010-09-307637","volume":"117","author":"Nytko KJ","year":"2011","unstructured":"Nytko KJ, Maeda N, Schl\u00e4fli P, Spielmann P, Wenger RH, Stiehl DP. Vitamin C is dispensable for oxygen sensing in vivo. Blood, 2011, 117: 5485-5493.","journal-title":"Blood"},{"key":"null","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/hep.24256","volume":"53","author":"Nath B","year":"2011","unstructured":"Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D. Hepatocyte-specific hypoxia-inducible factor-1\u03b1 is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology, 2011, 53: 1526-1537.","journal-title":"Hepatology"},{"key":"null","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/jn\/134.9.2216","volume":"134","author":"Kuo SM","year":"2004","unstructured":"Kuo SM, MacLean ME, McCormick K, Wilson JX. Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice. J Nutr, 2004, 134: 2216-2221.","journal-title":"J Nutr"},{"key":"null","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1080\/14786419.2010.495070","volume":"25","author":"Zhang Y","year":"2011","unstructured":"Zhang Y, Gao Z, Liu J, Xu Z. Protective effects of baicalin and quercetin on an iron-overloaded mouse: comparison of liver, kidney and heart tissues. Nat Prod Res, 2011, 25: 1150-1160.","journal-title":"Nat Prod Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/15376510903559950","volume":"20","author":"Kaur J","year":"2010","unstructured":"Kaur J, Shalini S, Bansal MP. Influence of vitamin E on alcohol-induced changes in antioxidant defenses in mice liver. Toxicol Mech Methods, 2010, 20: 82-89.","journal-title":"Toxicol Mech Methods"},{"key":"null","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1053\/gast.2003.50087","volume":"124","author":"Arteel GE","year":"2003","unstructured":"Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology, 2003, 124: 778-790.","journal-title":"Gastroenterology"},{"key":"null","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1034\/j.1600-0676.2003.00832.x","volume":"23","author":"Brown KE","year":"2003","unstructured":"Brown KE, Dennery PA, Ridnour LA, Fimmel CJ, Kladney RD, Brunt EM, Spitz DR. Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver Int, 2003, 23: 232-242.","journal-title":"Liver Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1476-5381.2011.01350.x","volume":"164","author":"May JM","year":"2011","unstructured":"May JM. The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C. Br J Pharmacol, 2011, 164: 1793-1801.","journal-title":"Br J Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.abb.2010.01.012","volume":"496","author":"Amano A","year":"2010","unstructured":"Amano A, Aigaki T, Maruyama N, Ishigami A. Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30\/GNL knockout mice. Arch Biochem Biophys, 2010, 496: 38-44.","journal-title":"Arch Biochem Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1271\/bbb.110312","volume":"75","author":"Sone Y","year":"2011","unstructured":"Sone Y, Ueta E, Kodama S, Sannoumaru Y, Miyake N, Sone H, Fujiwara Y. The level of orally ingested vitamin C affected the expression of vitamin C transporters and vitamin C accumulation in the livers of ODS rats. Biosci Biotechnol Biochem, 2011, 75: 2394-2397.","journal-title":"Biosci Biotechnol Biochem"},{"key":"null","first-page":"173","volume":"44","author":"Zolch Z","year":"1995","unstructured":"Zolch Z, Ginter E. Moderate alcohol consumption and vitamin C status in the guinea-pig and the rat. Physiol Res, 1995, 44: 173-178.","journal-title":"Physiol Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bbrc.2011.09.146","volume":"414","author":"Meredith ME","year":"2011","unstructured":"Meredith ME, Harrison FE, May JM. Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem Biophys Res Commun, 2011, 414: 737-742.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.freeradbiomed.2008.12.018","volume":"46","author":"Harrison FE","year":"2009","unstructured":"Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med, 2009, 46: 719-730.","journal-title":"Free Radic Biol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"e17139","DOI":"10.1371\/journal.pone.0017139","volume":"6","author":"Gess B","year":"2011","unstructured":"Gess B, Sevimli S, Strecker JK, Young P, Sch\u00e4bitz WR. Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillary endothelial cells after transient ischemia in mice. PLoS ONE, 2011, 6:","journal-title":"PLoS ONE"},{"key":"null","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408360701713104","volume":"45","author":"Galaris D","year":"2008","unstructured":"Galaris D, Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci, 2008, 45: 1-23.","journal-title":"Crit Rev Clin Lab Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1158\/0008-5472.CAN-08-1490","volume":"68","author":"Heaney ML","year":"2008","unstructured":"Heaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, O'Connor OA. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res, 2008, 68: 8031-8038.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2165\/11317890-000000000-00000","volume":"39","author":"McGinley C","year":"2009","unstructured":"McGinley C, Shafat A, Donnelly AE. Does antioxidant vitamin supplementation protect against muscle damage?. Sports Med, 2009, 39: 1011-1032.","journal-title":"Sports Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.freeradbiomed.2011.05.042","volume":"51","author":"Comito G","year":"2011","unstructured":"Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, Torre E, Migliore C. HIF-1\u03b1 stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med, 2011, 51: 893-904.","journal-title":"Free Radic Biol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.semcdb.2005.03.010","volume":"16","author":"Kietzmann T","year":"2005","unstructured":"Kietzmann T, G\u00f6rlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin Cell Dev Biol, 2005, 16: 474-486.","journal-title":"Semin Cell Dev Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/abbs\/gms004","volume":"44","author":"Guo X","year":"2012","unstructured":"Guo X, Lu J, Wang Y, Gui Y, Duan X, Cai Z. Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. Acta Biochim Biophys Sin, 2012, 44: 330-338.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.freeradbiomed.2006.11.023","volume":"42","author":"Vissers MC","year":"2007","unstructured":"Vissers MC, Gunningham SP, Morrison MJ, Dachs GU, Currie MJ. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radic Biol Med, 2007, 42: 765-772.","journal-title":"Free Radic Biol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.freeradbiomed.2006.11.028","volume":"42","author":"Savini I","year":"2007","unstructured":"Savini I, Catani MV, Arnone R, Rossi A, Frega G, Del Principe D, Avigliano L. Translational control of the ascorbic acid transporter SVCT2 in human platelets. Free Radic Biol Med, 2007, 42: 608-616.","journal-title":"Free Radic Biol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbrc.2007.07.007","volume":"361","author":"Savini I","year":"2007","unstructured":"Savini I, Rossi A, Catani MV, Ceci R, Avigliano L. Redox regulation of vitamin C transporter SVCT2 in C2C12 myotubes. Biochem Biophys Res Commun, 2007, 361: 385-390.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.febslet.2011.01.036","volume":"585","author":"Hausmann A","year":"2011","unstructured":"Hausmann A, Lee J, Pantopoulos K. Redox control of iron regulatory protein 2 stability. FEBS Lett, 2011, 585: 687-692.","journal-title":"FEBS Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"160","DOI":"10.7150\/ijms.3.160","volume":"3","author":"Castaneda F","year":"2006","unstructured":"Castaneda F, Rosin-Steiner S. Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways. Int J Med Sci, 2006, 3: 160-167.","journal-title":"Int J Med Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1017\/S0007114511002273","volume":"106","author":"Macias RI","year":"2011","unstructured":"Macias RI, Hierro C, de Juan SC, Jimenez F, Gonzalez-San Martin F, Marin JJ. Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases. Br J Nutr, 2011, 106: 1814-1825.","journal-title":"Br J Nutr"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/FB742484EC4F40AB8B49D0985173A333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmt099","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/FB742484EC4F40AB8B49D0985173A333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T09:35:42Z","timestamp":1716024942000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmt099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmt099","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}