{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:00:31Z","timestamp":1792843231203,"version":"4.5.0"},"reference-count":62,"publisher":"China Science Publishing & Media Ltd.","issue":"12","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270420"],"award-info":[{"award-number":["81270420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470434"],"award-info":[{"award-number":["81470434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503074"],"award-info":[{"award-number":["81503074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Cooperative innovation Center for Molecular Target New Drug Study"},{"name":"Hunan Provincial Education Department","award":["2014-405"],"award-info":[{"award-number":["2014-405"]}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["14JJ3102"],"award-info":[{"award-number":["14JJ3102"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M560647"],"award-info":[{"award-number":["2014M560647"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015T80875"],"award-info":[{"award-number":["2015T80875"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.1093\/abbs\/gmv111","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T15:52:46Z","timestamp":1448466766000},"page":"969-980","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1\/2-p70S6K and PI3K-induced autophagy"],"prefix":"10.3724","volume":"47","author":[{"given":"Feng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuping","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/abbs\/gmu032","volume":"46","author":"Xie F","year":"2014","unstructured":"Xie F, Lv D, Chen L. ELABELA: a novel hormone in cardiac development acting as a new endogenous ligand for the APJ receptor. Acta Biochim Biophys Sin, 2014, 46: 620-622.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1021\/pr200725x","volume":"10","author":"Mesmin C","year":"2011","unstructured":"Mesmin C, Fenaille F, Becher F, Tabet JC, Ezan E. Identification and characterization of apelin peptides in bovine colostrum and milk by liquid chromatography-mass spectrometry. J Proteome Res, 2011, 10: 5222-5231.","journal-title":"J Proteome Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1021\/bi030049s","volume":"42","author":"Fan X","year":"2003","unstructured":"Fan X, Zhou N, Zhang X, Mukhtar M, Lu Z, Fang J, DuBois GC. Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemistry, 2003, 42: 10163-10168.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/HYPERTENSIONAHA.109.134619","volume":"54","author":"Maguire JJ","year":"2009","unstructured":"Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension, 2009, 54: 598-604.","journal-title":"Hypertension"},{"key":"null","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/en.2004-0359","volume":"146","author":"Lee DK","year":"2005","unstructured":"Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology, 2005, 146: 231-236.","journal-title":"Endocrinology"},{"key":"null","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1007\/s11033-014-3552-4","volume":"41","author":"Wu D","year":"2014","unstructured":"Wu D, He L, Chen L. Apelin\/APJ system: a promising therapy target for hypertension. Mol Biol Rep, 2014, 41: 6691-6703.","journal-title":"Mol Biol Rep"},{"key":"null","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.peptides.2013.05.006","volume":"46","author":"Azizi Y","year":"2013","unstructured":"Azizi Y, Faghihi M, Imani A, Roghani M, Nazari A. Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction. Peptides, 2013, 46: 76-82.","journal-title":"Peptides"},{"key":"null","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1253\/circj.CJ-11-0689","volume":"76","author":"Koguchi W","year":"2012","unstructured":"Koguchi W, Kobayashi N, Takeshima H, Ishikawa M, Sugiyama F, Ishimitsu T. Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure. Circ J, 2012, 76: 137-144.","journal-title":"Circ J"},{"key":"null","doi-asserted-by":"crossref","first-page":"H1471","DOI":"10.1152\/ajpheart.00097.2011","volume":"301","author":"Tao J","year":"2011","unstructured":"Tao J, Zhu W, Li Y, Xin P, Li J, Liu M, Li J. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion. Am J Physiol Heart Circ Physiol, 2011, 301: H1471-H1486.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"H605","DOI":"10.1152\/ajpheart.00366.2012","volume":"303","author":"Li L","year":"2012","unstructured":"Li L, Zeng H, Chen JX. Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction. Am J Physiol Heart Circ Physiol, 2012, 303: H605-H618.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.2741\/2967","volume":"13","author":"Li F","year":"2008","unstructured":"Li F, Li L, Qin X, Pan W, Feng F, Chen F, Zhu B. Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1. Front Biosci, 2008, 13: 3786-3792.","journal-title":"Front Biosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/abbs\/gmt085","volume":"45","author":"Li L","year":"2013","unstructured":"Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D. Jagged-1\/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation. Acta Biochim Biophys Sin, 2013, 45: 875-881.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/abbs\/gmq035","volume":"42","author":"Liu C","year":"2010","unstructured":"Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F. PI3K\/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13. Acta Biochim Biophys Sin, 2010, 42: 396-402.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/abbs\/gmq036","volume":"42","author":"Li X","year":"2010","unstructured":"Li X, Zhang X, Li F, Chen L, Li L, Qin X, Gao J. 14-3-3 mediates apelin-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells. Acta Biochim Biophys Sin, 2010, 42: 403-409.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3724\/SP.J.1206.2011.00335","volume":"38","author":"Mao X","year":"2011","unstructured":"Mao X, Su T, Zhang X, Li F, Qin X, Li X, Liao D. Apelin-13 promote monocytes adhesion to HUVECs via PI3K signaling. Prog Biochen Biophys, 2011, 38: 1162-1170.","journal-title":"Prog Biochen Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/abbs\/gmt040","volume":"45","author":"Lv D","year":"2013","unstructured":"Lv D, Li H, Chen L. Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis. Acta Biochim Biophys Sin, 2013, 45: 527-533.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/14728220903485685","volume":"14","author":"Falcao-Pires I","year":"2010","unstructured":"Falcao-Pires I, Goncalves N, Gavina C, Pinho S, Teixeira T, Moura C, Amorim MJ. Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?. Expert Opin Ther Targets, 2010, 14: 231-241.","journal-title":"Expert Opin Ther Targets"},{"key":"null","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.febslet.2010.04.025","volume":"584","author":"Foussal C","year":"2010","unstructured":"Foussal C, Lairez O, Calise D, Pathak A, Guilbeau-Frugier C, Valet P, Parini A. Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett, 2010, 584: 2363-2370.","journal-title":"FEBS Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yjmcc.2013.07.002","volume":"63","author":"Ceylan-Isik AF","year":"2013","unstructured":"Ceylan-Isik AF, Kandadi MR, Xu X, Hua Y, Chicco AJ, Ren J, Nair S. Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol, 2013, 63: 4-13.","journal-title":"J Mol Cell Cardiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature11263","volume":"488","author":"Scimia MC","year":"2012","unstructured":"Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE. APJ acts as a dual receptor in cardiac hypertrophy. Nature, 2012, 488: 394-398.","journal-title":"Nature"},{"key":"null","first-page":"33","volume":"40","author":"Xie F","year":"2013","unstructured":"Xie F, Li LF, Chen LX. APJ acts as a reponse for pressure overload to induce myocardial hypertrophy. Prog Biochen Biophys, 2013, 40: 33-36.","journal-title":"Prog Biochen Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/abbs\/gmu046","volume":"46","author":"Xie F","year":"2014","unstructured":"Xie F, Liu W, Feng F, Li X, Yang L, Lv D, Qin X. A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway. Acta Biochim Biophys Sin, 2014, 46: 699-708.","journal-title":"Acta Biochim Biophys Sin"},{"key":"null","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/sj.leu.2404245","volume":"20","author":"Martelli AM","year":"2006","unstructured":"Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L. Phosphoinositide 3-kinase\/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia, 2006, 20: 911-928.","journal-title":"Leukemia"},{"key":"null","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nn1300","volume":"7","author":"Viard P","year":"2004","unstructured":"Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, Dolphin AC. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci, 2004, 7: 939-946.","journal-title":"Nat Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"H787","DOI":"10.1152\/ajpheart.00974.2005","volume":"291","author":"Samuelsson AM","year":"2006","unstructured":"Samuelsson AM, Bollano E, Mobini R, Larsson BM, Omerovic E, Fu M, Waagstein F. Hyperinsulinemia: effect on cardiac mass\/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol, 2006, 291: H787-H796.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtcvs.2006.07.042","volume":"133","author":"Wohlschlaeger J","year":"2007","unstructured":"Wohlschlaeger J, Schmitz KJ, Palatty J, Takeda A, Takeda N, Vahlhaus C, Levkau B. Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading. J Thorac Cardiovasc Surg, 2007, 133: 37-43.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"null","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000353164","volume":"131","author":"Tabe Y","year":"2014","unstructured":"Tabe Y, Jin L, Konopleva M, Shikami M, Kimura S, Andreeff M, Raffeld M. Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma. Acta Haematol, 2014, 131: 59-69.","journal-title":"Acta Haematol"},{"key":"null","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbrc.2010.05.031","volume":"396","author":"Perez-Perez A","year":"2010","unstructured":"Perez-Perez A, Gambino Y, Maymo J, Goberna R, Fabiani F, Varone C, Sanchez-Margalet V. MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. Biochem Biophys Res Commun, 2010, 396: 956-960.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","volume":"2","author":"Vivanco I","year":"2002","unstructured":"Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer, 2002, 2: 489-501.","journal-title":"Nat Rev Cancer"},{"key":"null","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"Levine B","year":"2008","unstructured":"Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell, 2008, 132: 27-42.","journal-title":"Cell"},{"key":"null","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s11427-013-4530-0","volume":"56","author":"Xie F","year":"2013","unstructured":"Xie F, Li L, Chen L. Autophagy, a new target for disease treatment. Sci China Life Sci, 2013, 56: 856-860.","journal-title":"Sci China Life Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"29776","DOI":"10.1074\/jbc.M603783200","volume":"281","author":"Hamacher-Brady A","year":"2006","unstructured":"Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes. J Bio Chem, 2006, 281: 29776-29787.","journal-title":"J Bio Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","volume":"100","author":"Matsui Y","year":"2007","unstructured":"Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res, 2007, 100: 914-922.","journal-title":"Circ Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12265-010-9189-3","volume":"3","author":"Huang C","year":"2010","unstructured":"Huang C, Yitzhaki S, Perry CN, Liu W, Giricz Z, Mentzer RM, Gottlieb RA. Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res, 2010, 3: 365-373.","journal-title":"J Cardiovasc Transl Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02932962","volume":"43","author":"Dammrich J","year":"1983","unstructured":"Dammrich J, Pfeifer U. Cardiac hypertrophy in rats after supravalvular aortic constriction. II. Inhibition of cellular autophagy in hypertrophying cardiomyocytes. Virchows Arch B Cell Pathol Incl Mol Pathol, 1983, 43: 287-307.","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"null","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35022604","volume":"406","author":"Nishino I","year":"2000","unstructured":"Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, Mora M. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature, 2000, 406: 906-910.","journal-title":"Nature"},{"key":"null","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.febslet.2010.02.054","volume":"584","author":"Vergne I","year":"2010","unstructured":"Vergne I, Deretic V. The role of PI3P phosphatases in the regulation of autophagy. FEBS Lett, 2010, 584: 1313-1318.","journal-title":"FEBS Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00395-011-0222-8","volume":"106","author":"Hua Y","year":"2011","unstructured":"Hua Y, Zhang Y, Ceylan-Isik AF, Wold LE, Nunn JM, Ren J. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res Cardiol, 2011, 106: 1173-1191.","journal-title":"Basic Res Cardiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.exer.2010.03.002","volume":"90","author":"Faghiri Z","year":"2010","unstructured":"Faghiri Z, Bazan NG. PI3K\/Akt and mTOR\/p70S6 K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp Eye Res, 2010, 90: 718-725.","journal-title":"Exp Eye Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-4827(76)90447-X","volume":"98","author":"Kimes BW","year":"1976","unstructured":"Kimes BW, Brandt BL. Properties of a clonal muscle cell line from rat heart. Exp Cell Res, 1976, 98: 367-381.","journal-title":"Exp Cell Res"},{"key":"null","first-page":"241","volume":"2","author":"Chen K","year":"2005","unstructured":"Chen K, Iribarren P, Gong W, Wang JM. The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer. Cell Mol Immunol, 2005, 2: 241-252.","journal-title":"Cell Mol Immunol"},{"key":"null","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4161\/auto.9099","volume":"5","author":"Wu YT","year":"2009","unstructured":"Wu YT, Tan HL, Huang Q, Ong CN, Shen HM. Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy, 2009, 5: 824-834.","journal-title":"Autophagy"},{"key":"null","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/auto.7.2.14074","volume":"7","author":"Saiki S","year":"2011","unstructured":"Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H. Caffeine induces apoptosis by enhancement of autophagy via PI3K\/Akt\/mTOR\/p70S6 K inhibition. Autophagy, 2011, 7: 176-187.","journal-title":"Autophagy"},{"key":"null","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/bj20030826","volume":"376","author":"Tassa A","year":"2003","unstructured":"Tassa A, Roux MP, Attaix D, Bechet DM. Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem J, 2003, 376: 577-586.","journal-title":"Biochem J"},{"key":"null","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/toxsci\/kfq170","volume":"117","author":"Castino R","year":"2010","unstructured":"Castino R, Bellio N, Follo C, Murphy D, Isidoro C. Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells. Toxicol Sci, 2010, 117: 152-162.","journal-title":"Toxicol Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4161\/auto.6.1.10535","volume":"6","author":"Farre JC","year":"2010","unstructured":"Farre JC, Mathewson RD, Manjithaya R, Subramani S. Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways. Autophagy, 2010, 6: 86-99.","journal-title":"Autophagy"},{"key":"null","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.amjcard.2008.03.081","volume":"102","author":"Gaasch WH","year":"2008","unstructured":"Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol, 2008, 102: 459-462.","journal-title":"Am J Cardiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/ars.2006.8.1081","volume":"8","author":"Gupta MK","year":"2006","unstructured":"Gupta MK, Neelakantan TV, Sanghamitra M, Tyagi RK, Dinda A, Maulik S, Mukhopadhyay CK. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxid Redox Signal, 2006, 8: 1081-1093.","journal-title":"Antioxid Redox Signal"},{"key":"null","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1152\/japplphysiol.00994.2009","volume":"108","author":"Koshman YE","year":"2010","unstructured":"Koshman YE, Piano MR, Russell B, Schwertz DW. Signaling responses after exposure to 5 alpha-dihydrotestosterone or 17 beta-estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes. J Appl Physiol, 2010, 108: 686-696.","journal-title":"J Appl Physiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1172\/JCI3077","volume":"102","author":"Tsoporis JN","year":"1998","unstructured":"Tsoporis JN, Marks A, Kahn HJ, Butany JW, Liu PP, O'Hanlon D, Parker TG. Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice. J Clin Invest, 1998, 102: 1609-1616.","journal-title":"J Clin Invest"},{"key":"null","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3181\/0707-RM-206","volume":"233","author":"Zou XJ","year":"2008","unstructured":"Zou XJ, Yang L, Yao SL. Propofol depresses angiotensin II-induced cardiomyocyte hypertrophy in vitro. Exp Biol Med (Maywood), 2008, 233: 200-208.","journal-title":"Exp Biol Med (Maywood)"},{"key":"null","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbrc.2009.05.151","volume":"386","author":"Vanamala SK","year":"2009","unstructured":"Vanamala SK, Gopinath S, Gondi CS, Rao JS. Effect of human umbilical cord blood cells on Ang-II-induced hypertrophy in mice. Biochem Biophys Res Commun, 2009, 386: 386-391.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCRESAHA.110.228437","volume":"108","author":"Yang Y","year":"2011","unstructured":"Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98\/let-7. Circ Res, 2011, 108: 305-313.","journal-title":"Circ Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.bbamcr.2008.07.014","volume":"1793","author":"Eskelinen EL","year":"2009","unstructured":"Eskelinen EL, Saftig P. Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta, 2009, 1793: 664-673.","journal-title":"Biochim Biophys Acta"},{"key":"null","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1083\/jcb.150.6.1507","volume":"150","author":"Kamada Y","year":"2000","unstructured":"Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol, 2000, 150: 1507-1513.","journal-title":"J Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1091\/mbc.e02-07-0413","volume":"14","author":"Abeliovich H","year":"2003","unstructured":"Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell, 2003, 14: 477-490.","journal-title":"Mol Biol Cell"},{"key":"null","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/embo-reports\/kve061","volume":"2","author":"Kihara A","year":"2001","unstructured":"Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep, 2001, 2: 330-335.","journal-title":"EMBO Rep"},{"key":"null","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1083\/jcb.152.3.519","volume":"152","author":"Kihara A","year":"2001","unstructured":"Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol, 2001, 152: 519-530.","journal-title":"J Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1242\/jcs.00381","volume":"116","author":"Mizushima N","year":"2003","unstructured":"Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, Natsume T. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci, 2003, 116: 1679-1688.","journal-title":"J Cell Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nsmb.2431","volume":"20","author":"Otomo C","year":"2013","unstructured":"Otomo C, Metlagel Z, Takaesu G, Otomo T. Structure of the human ATG12\u223cATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol, 2013, 20: 59-66.","journal-title":"Nat Struct Mol Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1093\/emboj\/20.21.5971","volume":"20","author":"Suzuki K","year":"2001","unstructured":"Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J, 2001, 20: 5971-5981.","journal-title":"EMBO J"},{"key":"null","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1172\/JCI66339","volume":"124","author":"Zaglia T","year":"2014","unstructured":"Zaglia T, Milan G, Ruhs A, Franzoso M, Bertaggia E, Pianca N, Carpi A. Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J Clin Invest, 2014, 124: 2410-2424.","journal-title":"J Clin Invest"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/265B0398DA224B4781A0393452713B2A","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmv111","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/265B0398DA224B4781A0393452713B2A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T17:51:11Z","timestamp":1718214671000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmv111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,1]]},"published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmv111","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}