{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:45:56Z","timestamp":1742399156934,"version":"3.37.3"},"reference-count":46,"publisher":"China Science Publishing & Media Ltd.","issue":"2","funder":[{"name":"National Key Basic Research Program of China","award":["2014CB744502"],"award-info":[{"award-number":["2014CB744502"]}]},{"name":"National High Technology Research and Development Program of China","award":["2015AA020502"],"award-info":[{"award-number":["2015AA020502"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21573290","21273288"],"award-info":[{"award-number":["21573290","21273288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Specialized Research Fund for the Doctor Program of Higher Education","award":["20120162110018"],"award-info":[{"award-number":["20120162110018"]}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2017,2,1]]},"DOI":"10.1093\/abbs\/gmw126","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T12:07:06Z","timestamp":1480594026000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Role of norepinephrine in Aβ-related neurotoxicity: dual interactions with Tyr<sup>10<\/sup> and SNK(26–28) of Aβ"],"prefix":"10.3724","volume":"49","author":[{"given":"Mengmeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannan","family":"Bin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/path.2885","volume":"224","author":"Castellani RJ","year":"2011","unstructured":"Castellani RJ, Smith MA. Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is \u2018too big to fail\u2019. J Pathol, 2011, 224: 147-152.","journal-title":"J Pathol"},{"key":"null","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","volume":"82","author":"Masters CL","year":"1985","unstructured":"Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA, 1985, 82: 4245-4249.","journal-title":"Proc Natl Acad Sci USA"},{"key":"null","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","volume":"298","author":"Selkoe DJ","year":"2002","unstructured":"Selkoe DJ. Alzheimer's disease is a synaptic failure. Science, 2002, 298: 789-791.","journal-title":"Science"},{"key":"null","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bpj.2008.09.053","volume":"3","author":"Davis CH","year":"2009","unstructured":"Davis CH, Berkowitz ML. Interaction between amyloid-\u03b2 (1\u201342) peptide and phospholipid bilayers: a molecular dynamics study. Biophys J, 2009, 3: 785-797.","journal-title":"Biophys J"},{"key":"null","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jmb.2008.07.072","volume":"382","author":"Okada T","year":"2008","unstructured":"Okada T, Ikeda K, Wakabayashi M, Ogawa M, Matsuzaki K. Formation of toxic A\u03b2(1\u201340) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: polymorphisms in A\u03b2(1\u201340) fibrils. J Mol Biol, 2008, 382: 1066-1074.","journal-title":"J Mol Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1073\/pnas.0503181102","volume":"102","author":"Marchesi VT","year":"2005","unstructured":"Marchesi VT. An alternative interpretation of the amyloid A\u03b2 hypothesis with regard to the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci USA, 2005, 102: 9093-9098.","journal-title":"Proc Natl Acad Sci USA"},{"key":"null","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1021\/bi0358824","volume":"43","author":"Atwood CS","year":"2004","unstructured":"Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry, 2004, 43: 560-568.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jinorgbio.2012.10.013","volume":"119","author":"Bin Y","year":"2013","unstructured":"Bin Y, Chen S, Xiang J. pH-dependent kinetics of copper ions binding to amyloid-\u03b2 peptide. J Inorg Biochem, 2013, 119: 21-27.","journal-title":"J Inorg Biochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nsmb1345","volume":"14","author":"Chimon S","year":"2007","unstructured":"Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y. Evidence of fibril-like \u03b2-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's \u03b2-amyloid. Nat Struct Mol Biol, 2007, 14: 1157-1164.","journal-title":"Nat Struct Mol Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","volume":"300","author":"Kayed R","year":"2003","unstructured":"Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science, 2003, 300: 486-489.","journal-title":"Science"},{"key":"null","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1523\/JNEUROSCI.1189-06.2006","volume":"26","author":"Deshpande A","year":"2006","unstructured":"Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of Amyloid-\u03b2 induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci, 2006, 26: 6011-6018.","journal-title":"J Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1096\/fj.03-0770fje","volume":"18","author":"Li J","year":"2004","unstructured":"Li J, Zhu M, Manning-Bog AB, Di MD, Fink AL. Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease. FASEB J, 2004, 18: 962-964.","journal-title":"FASEB J"},{"key":"null","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jbiosc.2009.11.010","volume":"109","author":"Huong VT","year":"2010","unstructured":"Huong VT, Shimanouchi T, Shimauchi N. Catechol derivatives inhibit the fibril formation of amyloid-\u03b2 peptides. J Biosci Bioeng, 2010, 109: 629-634.","journal-title":"J Biosci Bioeng"},{"key":"null","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1755-5949.2010.00161.x","volume":"17","author":"Mitchell RA","year":"2011","unstructured":"Mitchell RA, Herrmann N, Lanct\u00f4t KL. The role of dopamine in symptoms and treatment of apathy in Alzheimer's disease. CNS Neurosci Ther, 2011, 17: 411-427.","journal-title":"CNS Neurosci Ther"},{"key":"null","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1101\/lm.026070.112","volume":"19","author":"Guzman-Ramos K","year":"2012","unstructured":"Guzman-Ramos K, Moreno-Castilla P, Castro-Cruz M, McGaugh JL, Mart\u00ednez-Coria H, LaFerla FM, Berm\u00fadez-Rattoni F. Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. Learn Mem, 2012, 19: 453-460.","journal-title":"Learn Mem"},{"key":"null","doi-asserted-by":"crossref","first-page":"23212","DOI":"10.1074\/jbc.M113.464222","volume":"288","author":"Sato M","year":"2013","unstructured":"Sato M, Murakami K, Uno M, Nakagawa Y, Katayama S, Akagi K, Masuda Y. Site-specific inhibitory mechanism for amyloid \u03b242 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem, 2013, 288: 23212-23224.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S1092852900001358","volume":"6","author":"Ressler KJ","year":"2001","unstructured":"Ressler KJ, Nemeroff CB. Role of norepinephrine in the pathophysiology of neuropsychiatric disorders. CNS Spectr, 2001, 6: 663-670.","journal-title":"CNS Spectr"},{"key":"null","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/jnp.16.3.261","volume":"16","author":"Herrmann N","year":"2004","unstructured":"Herrmann N, Lanctot KL, Khan LR. The role of norepinephrine in the behavioral and psychological symptoms of dementia. J Neuropsychiatry Clin Neurosci, 2004, 16: 261-276.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/nbdi.1998.0192","volume":"5","author":"Fu W","year":"1998","unstructured":"Fu W, Luo H. Catecholamines potentiate amyloid \u03b2-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis. Neurobiol Dis, 1998, 5: 229-243.","journal-title":"Neurobiol Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.neurobiolaging.2006.06.003","volume":"28","author":"Kalinin S","year":"2007","unstructured":"Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging, 2007, 28: 1206-1214.","journal-title":"Neurobiol Aging"},{"key":"null","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3233\/JAD-141062","volume":"44","author":"Liu X","year":"2015","unstructured":"Liu X, Ye K, Weinshenker D. Norepinephrine protects against amyloid-beta toxicity via TrkB. J Alzheimers Dis, 2015, 44: 251-260.","journal-title":"J Alzheimers Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0891-5849(01)00580-9","volume":"31","author":"Andorn AC","year":"2001","unstructured":"Andorn AC, Pappolla MA. Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain. Free Radical Biol Med, 2001, 31: 315-320.","journal-title":"Free Radical Biol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/abbi.1993.1189","volume":"302","author":"Liu J","year":"1993","unstructured":"Liu J, Mori A. Monoamine metabolism provides an antioxidant defense in the brain against oxidant- and free radical-induced damage. Arch Biochem Biophys, 1993, 302: 118-127.","journal-title":"Arch Biochem Biophys"},{"key":"null","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1042\/BST20120086","volume":"40","author":"Cuchillo R","year":"2012","unstructured":"Cuchillo R, Michel J. Mechanisms of small-molecule binding to intrinsically disordered proteins. Biochem Soc Trans, 2012, 40: 1004-1008.","journal-title":"Biochem Soc Trans"},{"key":"null","first-page":"255","author":"Clark DL","year":"2005","journal-title":"The Brain and Behavior: An Introduction to Behavioval Neuroanatomy"},{"key":"null","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jinorgbio.2016.09.007","volume":"164","author":"Liu MM","year":"2016","unstructured":"Liu MM, Kou L, Bin YN, Wan LP, Xiang J. Complicated function of dopamine in A\u03b2-related neurotoxicity: dual interactions with Tyr10 and SNK(26\u201328) of A\u03b2. J Inorg Biochem, 2016, 164: 119-128.","journal-title":"J Inorg Biochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bios.2008.04.012","volume":"24","author":"Xin Y","year":"2008","unstructured":"Xin Y, Gao Y, Guo J, Chen Q, Xiang J, Zhou FM. Real-time detection of Cu2+ sequestration and release by immobilized apo-metallothioneins using SECM combined with SPR. Biosens Bioelectron, 2008, 24: 369-375.","journal-title":"Biosens Bioelectron"},{"key":"null","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1021\/la9910834","volume":"16","author":"Huang E","year":"2000","unstructured":"Huang E, Zhou F, Deng L. Studies of surface coverage and orientation of DNA molecules immobilized onto preformed alkanethiol self-assembled monolayers. Langmuir, 2000, 16: 3272-3280.","journal-title":"Langmuir"},{"key":"null","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1021\/bi701899y","volume":"47","author":"Morris AM","year":"2008","unstructured":"Morris AM, Watzky MA, Agar JN, Finke RG. Fitting neurological protein aggregation kinetic data via a 2-step, minimal\/\u2018Ockham's Razor\u2019 model: the finke\u2212watzky mechanism of nucleation followed by autocatalytic surface growth. Biochemistry, 2008, 47: 2413-2427.","journal-title":"Biochemistry"},{"key":"null","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1021\/jm00223a008","volume":"19","author":"Tse DCS","year":"1976","unstructured":"Tse DCS, McCreery RL, Adams RN. Potential oxidative pathways of brain catecholamines. J Med Chem, 1976, 19: 37-40.","journal-title":"J Med Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1021\/ja001901a","volume":"122","author":"Tsuzuki S","year":"2000","unstructured":"Tsuzuki S, Honda K, Uchimaru T, Mikami AM, Tanabe K. Origin of the attraction and directionality of the NH\/\u03c0 interaction: comparison with OH\/\u03c0 and CH\/\u03c0 interactions. J Am Chem Soc, 2000, 122: 11450-11458.","journal-title":"J Am Chem Soc"},{"key":"null","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/abio.1993.1355","volume":"212","author":"Oshannessy DJ","year":"1993","unstructured":"Oshannessy DJ, Brighamburke M, Soneson KK, Hensley P, Brooks I. Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: use of nonlinear least squares analysis methods. Anal Biochem, 1993, 212: 457-468.","journal-title":"Anal Biochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1021\/ac0494275","volume":"76","author":"Wegner GJ","year":"2004","unstructured":"Wegner GJ, Wegner GJ, Wark AW, Lee HJ, Codner E, Saeki T, Fang SP. Real-time surface plasmon resonance imaging measurements for the multiplexed determination of protein adsorption\/desorption kinetics and surface enzymatic reactions on peptide microarrays. Anal Chem, 2004, 76: 5677-5684.","journal-title":"Anal Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.bbrc.2007.07.082","volume":"361","author":"Nuria BC","year":"2007","unstructured":"Nuria BC, Mercedes C, Josep C. Conversion of non-fibrillar \u03b2-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation. Biochem Biophys Res Com, 2007, 361: 916-921.","journal-title":"Biochem Biophys Res Com"},{"key":"null","doi-asserted-by":"crossref","first-page":"15008","DOI":"10.1021\/ja203407v","volume":"133","author":"Al\u00ed-Torres J","year":"2011","unstructured":"Al\u00ed-Torres J, Marechal JD, Rodriguez-Santiago L, Sodupe M. Three dimensional models of Cu2+-A\u03b2(1\u201316) complexes from computational approaches. J Am Chem Soci, 2011, 133: 15008-15014.","journal-title":"J Am Chem Soci"},{"key":"null","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1021\/ja903669a","volume":"131","author":"Drew SC","year":"2009","unstructured":"Drew SC, Masters CL, Barnham KJ. Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-\u03b2 peptide-relevance to N-terminally truncated forms. J Am Chem Soc, 2009, 131: 8760-8761.","journal-title":"J Am Chem Soc"},{"key":"null","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/bbrc.1997.6756","volume":"235","author":"Pecci L","year":"1997","unstructured":"Pecci L, Montefoschi G, Cavallini D. Some new details of the copper-hydrogen peroxide interaction. Biochem Biophys Res Commun, 1997, 235: 264-267.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/cbic.200700111","volume":"8","author":"Guilloreau L","year":"2007","unstructured":"Guilloreau L, Combalbert S, Soumia-Saquet A, Mazarguil H, Faller P. Redox chemistry of copper-amyloid-beta: the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state. Chembiochem, 2007, 8: 1317-1325.","journal-title":"Chembiochem"},{"key":"null","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1021\/jp9095375","volume":"114","author":"Jiang D","year":"2010","unstructured":"Jiang D, Li XJ, Liu L, Yagnik GB, Zhou FM. Reaction rates and mechanism of the ascorbic acid oxidation by molecular oxygen facilitated by Cu(II)-containing amyloid-\u03b2 complexes and aggregates. J Phys Chem B, 2010, 114: 4896-4903.","journal-title":"J Phys Chem B"},{"key":"null","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-2236(99)01543-X","volume":"23","author":"Rice ME","year":"2000","unstructured":"Rice ME. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci, 2000, 23: 209-216.","journal-title":"Trends Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.bbamem.2007.02.002","volume":"1768","author":"Smith DG","year":"2007","unstructured":"Smith DG, Cappai R, Barnham KJ. The redox chemistry of the Alzheimer's disease amyloid \u03b2 peptide. Biochim Biophys Acta, 2007, 1768: 1976-1990.","journal-title":"Biochim Biophys Acta"},{"key":"null","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1523\/JNEUROSCI.2985-10.2010","volume":"30","author":"Kong Y","year":"2010","unstructured":"Kong Y, Ruan LF, Qian LH, Liu XL, Le YY. Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme. J Neurosci, 2010, 30: 11848-11857.","journal-title":"J Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"52781","DOI":"10.1074\/jbc.M406262200","volume":"279","author":"Morimoto A","year":"2004","unstructured":"Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, FuKuda H. Analysis of the secondary structure of beta-amyloid fibrils by systematic proline replacement. J Biol Chem, 2004, 279: 52781-52788.","journal-title":"J Biol Chem"},{"key":"null","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35081564","volume":"2","author":"Goedert M","year":"2001","unstructured":"Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci, 2001, 2: 492-501.","journal-title":"Nat Rev Neurosci"},{"key":"null","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12017-009-8082-1","volume":"11","author":"Bisaglia M","year":"2009","unstructured":"Bisaglia M, Tessari I, Mammi S, Bubacco L. Interaction between \u03b1-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease. Neuro Mol Med, 2009, 11: 239-251.","journal-title":"Neuro Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S1353-8020(09)70004-5","volume":"15","author":"Nagatsu T","year":"2009","unstructured":"Nagatsu T, Sawada M. L-DOPA therapy for Parkinson's disease: past, present, and future. Parkinsonism Relat Disord, 2009, 15: S3-S8.","journal-title":"Parkinsonism Relat Disord"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/CB3275AB33E34788920FE6FC808D9856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmw126","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/CB3275AB33E34788920FE6FC808D9856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:19:12Z","timestamp":1692591552000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmw126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,1]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,6]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmw126","relation":{},"ISSN":["1672-9145"],"issn-type":[{"type":"print","value":"1672-9145"}],"subject":[],"published":{"date-parts":[[2017,2,1]]}}}