{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:46:41Z","timestamp":1790275601476,"version":"4.1.0"},"reference-count":40,"publisher":"China Science Publishing & Media Ltd.","issue":"10","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1301226, 81373434, 81025021, and 91213304"],"award-info":[{"award-number":["U1301226, 81373434, 81025021, and 91213304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Education Bureau of Guangdong Province","award":["cxzd1103"],"award-info":[{"award-number":["cxzd1103"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/abbs\/gmx089","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T19:20:12Z","timestamp":1501788012000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt\/&amp;beta;-catenin pathway"],"prefix":"10.3724","volume":"49","author":[{"given":"Lei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2026","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2217\/14796694.4.5.629","volume":"4","author":"Landreville S","year":"2008","unstructured":"Landreville S, Agapova OA, Harbour JW. Emerging insights into the molecular pathogenesis of uveal melanoma. Future Oncol, 2008, 4: 629-636.","journal-title":"Future Oncol"},{"key":"null","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ctrv.2012.01.002","volume":"38","author":"Spagnolo F","year":"2012","unstructured":"Spagnolo F, Caltabiano G, Queirolo P. Uveal melanoma. Cancer Treat Rev, 2012, 38: 549-553.","journal-title":"Cancer Treat Rev"},{"key":"null","doi-asserted-by":"crossref","first-page":"573974","DOI":"10.1155\/2011\/573974","volume":"2011","author":"Papastefanou VP","year":"2011","unstructured":"Papastefanou VP, Cohen VM. Uveal melanoma. J Skin Cancer, 2011, 2011:","journal-title":"J Skin Cancer"},{"key":"null","first-page":"5761","volume":"63","author":"Cruz F","year":"2003","unstructured":"Cruz F, Rubin BP, Wilson D, Town A, Schroeder A, Haley A, Bainbridge T. Absence of BRAF and NRAS mutations in uveal melanoma. Cancer Res, 2003, 63: 5761-5766.","journal-title":"Cancer Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","volume":"363","author":"Van Raamsdonk CD","year":"2010","unstructured":"Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC. Mutations in GNA11 in uveal melanoma. New Engl J Med, 2010, 363: 2191-2199.","journal-title":"New Engl J Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature07586","volume":"457","author":"Van Raamsdonk CD","year":"2009","unstructured":"Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature, 2009, 457: 599-602.","journal-title":"Nature"},{"key":"null","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1755-148X.2012.00979.x","volume":"25","author":"Harbour JW","year":"2012","unstructured":"Harbour JW. The genetics of uveal melanoma: an emerging framework for targeted therapy. Pigment Cell Melanoma Res, 2012, 25: 171-181.","journal-title":"Pigment Cell Melanoma Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/CMR.0000000000000121","volume":"24","author":"Shoushtari AN","year":"2014","unstructured":"Shoushtari AN, Carvajal RD. GNAQ and GNA11 mutations in uveal melanoma. Melanoma Res, 2014, 24: 525-534.","journal-title":"Melanoma Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"9092","DOI":"10.18632\/oncotarget.2377","volume":"5","author":"Chen Q","year":"2014","unstructured":"Chen Q, Cao HZ, Zheng PS. LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt\/beta-catenin signaling pathway. Oncotarget, 2014, 5: 9092-9105.","journal-title":"Oncotarget"},{"key":"null","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.canlet.2016.02.032","volume":"374","author":"Yong X","year":"2016","unstructured":"Yong X, Tang B, Xiao YF, Xie R, Qin Y, Luo G, Hu CJ. Helicobacter pylori upregulates Nanog and Oct4 via Wnt\/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. Cancer Lett, 2016, 374: 292-303.","journal-title":"Cancer Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"e63298","DOI":"10.1371\/journal.pone.0063298","volume":"8","author":"Santaolalla R","year":"2013","unstructured":"Santaolalla R, Sussman DA, Ruiz JR, Davies JM, Pastorini C, Espana CL, Sotolongo J. TLR4 activates the beta-catenin pathway to cause intestinal neoplasia. PloS One, 2013, 8:","journal-title":"PloS One"},{"key":"null","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/cas.12755","volume":"106","author":"Wang Z","year":"2015","unstructured":"Wang Z, Luo Z, Zhou L, Li X, Jiang T, Fu E. DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating beta-catenin signaling pathway. Cancer Sci, 2015, 106: 1303-1312.","journal-title":"Cancer Sci"},{"key":"null","doi-asserted-by":"crossref","first-page":"e94748","DOI":"10.1371\/journal.pone.0094748","volume":"9","author":"Chien AJ","year":"2014","unstructured":"Chien AJ, Haydu LE, Biechele TL, Kulikauskas RM, Rizos H, Kefford RF, Scolyer RA. Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt\/beta-catenin signaling. PLoS One, 2014, 9:","journal-title":"PLoS One"},{"key":"null","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/CMR.0b013e3282f1d302","volume":"17","author":"Zuidervaart W","year":"2007","unstructured":"Zuidervaart W, Pavey S, van Nieuwpoort RA, Packer L, Out C, Maat W, Jager MJ. Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma. Melanoma Res, 2007, 17: 380-386.","journal-title":"Melanoma Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/CMR.0b013e3283005270","volume":"18","author":"Chang SH","year":"2008","unstructured":"Chang SH, Worley LA, Onken MD, Harbour JW. Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis. Melanoma Res, 2008, 18: 191-200.","journal-title":"Melanoma Res"},{"key":"null","first-page":"147","volume":"19","author":"Sheth UK","year":"1975","unstructured":"Sheth UK. Mechanisms of anthelmintic action. Prog Drug Res, 1975, 19: 147-157.","journal-title":"Prog Drug Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00384-014-1975-y","volume":"29","author":"Wiegering A","year":"2014","unstructured":"Wiegering A, Uthe FW, Huttenrauch M, Muhling B, Linnebacher M, Krummenast F, Germer CT. The impact of pyrvinium pamoate on colon cancer cell viability. Int J Colorectal Dis, 2014, 29: 1189-1198.","journal-title":"Int J Colorectal Dis"},{"key":"null","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.canlet.2011.12.034","volume":"319","author":"Harada Y","year":"2012","unstructured":"Harada Y, Ishii I, Hatake K, Kasahara T. Pyrvinium pamoate inhibits proliferation of myeloma\/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. Cancer Lett, 2012, 319: 83-88.","journal-title":"Cancer Lett"},{"key":"null","doi-asserted-by":"crossref","first-page":"e71508","DOI":"10.1371\/journal.pone.0071508","volume":"8","author":"Xu W","year":"2013","unstructured":"Xu W, Lacerda L, Debeb BG, Atkinson RL, Solley TN, Li L, Orton D. The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer. PloS One, 2013, 8:","journal-title":"PloS One"},{"key":"null","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ijc.2910620208","volume":"62","author":"De Waard-Siebinga I","year":"1995","unstructured":"De Waard-Siebinga I, Blom DJ, Griffioen M, Schrier PI, Hoogendoorn E, Beverstock G, Danen EH. Establishment and characterization of an uveal-melanoma cell line. Int J Cancer, 1995, 62: 155-161.","journal-title":"Int J Cancer"},{"key":"null","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/A:1018479011340","volume":"15","author":"Chen PW","year":"1997","unstructured":"Chen PW, Murray TG, Uno T, Salgaller ML, Reddy R, Ksander BR. Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease. Clin Exp Metastasis, 1997, 15: 509-518.","journal-title":"Clin Exp Metastasis"},{"key":"null","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F","volume":"66","author":"Luyten GP","year":"1996","unstructured":"Luyten GP, Naus NC, Mooy CM, Hagemeijer A, Kan-Mitchell J, Van Drunen E, Vuzevski V. Establishment and characterization of primary and metastatic uveal melanoma cell lines. Int J Cancer, 1996, 66: 380-387.","journal-title":"Int J Cancer"},{"key":"null","doi-asserted-by":"crossref","first-page":"22622","DOI":"10.1038\/srep22622","volume":"6","author":"Dai W","year":"2016","unstructured":"Dai W, Zhou J, Jin B, Pan J. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep, 2016, 6:","journal-title":"Sci Rep"},{"key":"null","first-page":"2816","volume":"6","author":"Ma YW","year":"2016","unstructured":"Ma YW, Liu YZ, Pan JX. Verteporfin induces apoptosis and eliminates cancer stem-like cells in uveal melanoma in the absence of light activation. Am J Cancer Res, 2016, 6: 2816-2830.","journal-title":"Am J Cancer Res"},{"key":"null","first-page":"919","volume":"21","author":"Asnaghi L","year":"2015","unstructured":"Asnaghi L, Gezgin G, Tripathy A, Handa JT, Merbs SL, van der Velden PA, Jager MJ. EMT-associated factors promote invasive properties of uveal melanoma cells. Mol Vis, 2015, 21: 919-929.","journal-title":"Mol Vis"},{"key":"null","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1158\/0008-5472.CAN-09-3950","volume":"70","author":"Jin YL","year":"2010","unstructured":"Jin YL, Lu ZZ, Ding K, Li JA, Du X, Chen C, Sun XY. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappa B pathway and generation of reactive oxygen species. Cancer Res, 2010, 70: 2516-2527.","journal-title":"Cancer Res"},{"key":"null","author":"Zeng D","year":"2016","unstructured":"Zeng D, Liu M, Pan J. Blocking EZH2 methylation transferase activity by GSK126 decreases stem cell-like myeloma cells. Oncotarget, 2016,","journal-title":"Oncotarget"},{"key":"null","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","volume":"378","author":"Cross DA","year":"1995","unstructured":"Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature, 1995, 378: 785-789.","journal-title":"Nature"},{"key":"null","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1023\/A:1016119328968","volume":"7","author":"Soldani C","year":"2002","unstructured":"Soldani C, Scovassi AI. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis, 2002, 7: 321-328.","journal-title":"Apoptosis"},{"key":"null","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1074\/mcp.M113.034322","volume":"13","author":"Martinez-Fabregas J","year":"2014","unstructured":"Martinez-Fabregas J, Diaz-Moreno I, Gonzalez-Arzola K, Janocha S, Navarro JA, Hervas M, Bernhardt R. Structural and functional analysis of novel human cytochrome C targets in apoptosis. Mol Cell Proteomics, 2014, 13: 1439-1456.","journal-title":"Mol Cell Proteomics"},{"key":"null","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/archopht.119.5.670","volume":"119","year":"2001","unstructured":"Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15. Arch Ophthalmol, 2001, 119: 670-676.","journal-title":"Arch Ophthalmol"},{"key":"null","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.2004.08.194","volume":"22","author":"Diener-West M","year":"2004","unstructured":"Diener-West M, Reynolds SM, Agugliaro DJ, Caldwell R, Cumming K, Earle JD, Green DL. Screening for metastasis from choroidal melanoma: the Collaborative Ocular Melanoma Study Group Report 23. J Clin Oncol, 2004, 22: 2438-2444.","journal-title":"J Clin Oncol"},{"key":"null","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nchembio.453","volume":"6","author":"Thorne CA","year":"2010","unstructured":"Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1 alpha. Nat Chem Biol, 2010, 6: 829-836.","journal-title":"Nat Chem Biol"},{"key":"null","first-page":"2399","volume":"9","author":"Zhang X","year":"2015","unstructured":"Zhang X, Lou Y, Zheng X, Wang H, Sun J, Dong Q, Han B. Wnt blockers inhibit the proliferation of lung cancer stem cells. Drug Des Devel Ther, 2015, 9: 2399-2407.","journal-title":"Drug Des Devel Ther"},{"key":"null","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbagrm.2014.03.013","volume":"1849","author":"Bretones G","year":"2015","unstructured":"Bretones G, Delgado MD, Leon J. Myc and cell cycle control. Biochim Biophys Acta, 2015, 1849: 506-516.","journal-title":"Biochim Biophys Acta"},{"key":"null","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00109-016-1475-3","volume":"94","author":"Qie S","year":"2016","unstructured":"Qie S, Diehl JA. Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med, 2016, 94: 1313-1326.","journal-title":"J Mol Med"},{"key":"null","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bbrc.2015.12.059","volume":"469","author":"Xiao M","year":"2016","unstructured":"Xiao M, Zhang L, Zhou Y, Rajoria P, Wang C. Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2\/STAT5. Biochem Biophys Res Commun, 2016, 469: 716-722.","journal-title":"Biochem Biophys Res Commun"},{"key":"null","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/35080103","volume":"2","author":"Holcik M","year":"2001","unstructured":"Holcik M, Korneluk RG. XIAP, the guardian angel. Nat Rev Mol Cell Biol, 2001, 2: 550-556.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"null","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1529\/biophysj.105.068122","volume":"90","author":"Bagci EZ","year":"2006","unstructured":"Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I. Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J, 2006, 90: 1546-1559.","journal-title":"Biophys J"},{"key":"null","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/cpt1976196802","volume":"19","author":"Smith TC","year":"1976","unstructured":"Smith TC, Kinkel AW, Gryczko CM, Goulet JR. Absorption of pyrvinium pamoate. Clin Pharmacol Ther, 1976, 19: 802-806.","journal-title":"Clin Pharmacol Ther"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/45FF2939A8BC4420B82B5AF1858B6077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmx089","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/45FF2939A8BC4420B82B5AF1858B6077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T19:42:36Z","timestamp":1659296556000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmx089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,1]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmx089","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10,1]]}}}