{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:42:48Z","timestamp":1776894168603,"version":"3.51.2"},"reference-count":21,"publisher":"China Science Publishing & Media Ltd.","issue":"7","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"publisher","award":["81770505"],"award-info":[{"award-number":["81770505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"publisher","award":["81472570"],"award-info":[{"award-number":["81472570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Project of Shanghai Municipal Health and Family Planning Commission","award":["201740060"],"award-info":[{"award-number":["201740060"]}]}],"content-domain":{"domain":["engine.scichina.com"],"crossmark-restriction":false},"short-container-title":["ABBS"],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1093\/abbs\/gmy056","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T07:15:25Z","timestamp":1525072525000},"page":"658-665","update-policy":"https:\/\/doi.org\/10.1360\/scp-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Integrin β3 inhibits hypoxia-induced apoptosis in cardiomyocytes"],"prefix":"10.3724","volume":"50","author":[{"given":"Yifan","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2026","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"null","doi-asserted-by":"crossref","first-page":"3920195","DOI":"10.1155\/2017\/3920195","volume":"2017","author":"Schirone L","year":"2017","unstructured":"Schirone L, Forte M, Palmerio S, Yee D, Nocella C, Angelini F, Pagano F. A review of the molecular mechanisms underlying the development and progression of cardiac remodeling. Oxid Med Cell Longev, 2017, 2017:","journal-title":"Oxid Med Cell Longev"},{"key":"null","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","volume":"127","author":"Frangogiannis NG","year":"2017","unstructured":"Frangogiannis NG. The extracellular matrix in myocardial injury, repair, and remodeling. J Clin Invest, 2017, 127: 1600-1612.","journal-title":"J Clin Invest"},{"key":"null","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.devcel.2013.02.012","volume":"24","author":"Wolfenson H","year":"2013","unstructured":"Wolfenson H, Lavelin I, Geiger B. Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell, 2013, 24: 447-458.","journal-title":"Dev Cell"},{"key":"null","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/156800909788486713","volume":"9","author":"Sheldrake HM","year":"2009","unstructured":"Sheldrake HM, Patterson LH. Function and antagonism of beta3 integrins in the development of cancer therapy. Curr Cancer Drug Targets, 2009, 9: 519-540.","journal-title":"Curr Cancer Drug Targets"},{"key":"null","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/carcin\/bgi336","volume":"27","author":"Shen MR","year":"2006","unstructured":"Shen MR, Hsu YM, Hsu KF, Chen YF, Tang MJ, Chou CY. Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling. Carcinogenesis, 2006, 27: 962-971.","journal-title":"Carcinogenesis"},{"key":"null","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/FJC.0b013e3181d9f5d4","volume":"55","author":"Suryakumar G","year":"2010","unstructured":"Suryakumar G, Kasiganesan H, Balasubramanian S, Kuppuswamy D. Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium. J Cardiovasc Pharmacol, 2010, 55: 567-573.","journal-title":"J Cardiovasc Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000371489","volume":"130","author":"Zhu Y","year":"2015","unstructured":"Zhu Y, Li L, Gong S, Yu Y, Dai H, Cai G, Yan J. ss3-integrin inhibits lipopolysaccharide-induced autophagy in cardiomyocytes via the Akt signaling pathway. Cardiology, 2015, 130: 249-259.","journal-title":"Cardiology"},{"key":"null","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11010-017-3100-3","volume":"437","author":"Gordon JW","year":"2017","unstructured":"Gordon JW. Regulation of cardiac myocyte cell death and differentiation by myocardin. Mol Cell Biochem, 2017, 437: 119-131.","journal-title":"Mol Cell Biochem"},{"key":"null","first-page":"207","volume":"38","author":"Tian H","year":"2017","unstructured":"Tian H, Ge C, Zhao F, Zhu M, Zhang L, Huo Q, Li H. Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN\/Akt and CD44s pathways in hepatocellular carcinoma. Carcinogenesis, 2017, 38: 207-217.","journal-title":"Carcinogenesis"},{"key":"null","doi-asserted-by":"crossref","first-page":"30579","DOI":"10.18632\/oncotarget.5769","volume":"6","author":"Sun T","year":"2015","unstructured":"Sun T, Tang G, Tian H, Hu K, Yao S, Su Y, Wang C. Positron emission tomography imaging of cardiomyocyte apoptosis with a novel molecule probe [18F]FP-DPAZn2. Oncotarget, 2015, 6: 30579-30591.","journal-title":"Oncotarget"},{"key":"null","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/hep.26929","volume":"59","author":"Tian H","year":"2014","unstructured":"Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G. Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog\/Akt1 pathway in hepatocellular carcinoma. Hepatology, 2014, 59: 1459-1470.","journal-title":"Hepatology"},{"key":"null","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/2048872616689773","volume":"6","author":"Piepoli MF","year":"2017","unstructured":"Piepoli MF, Corra U, Dendale P, Frederix I, Prescott E, Schmid JP, Cupples M. Challenges in secondary prevention after acute myocardial infarction: a call for action. Eur Heart J Acute Cardiovasc Care, 2017, 6: 299-310.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"null","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.ijcard.2013.01.163","volume":"167","author":"Takemura G","year":"2013","unstructured":"Takemura G, Kanoh M, Minatoguchi S, Fujiwara H. Cardiomyocyte apoptosis in the failing heart\u2014a critical review from definition and classification of cell death. Int J Cardiol, 2013, 167: 2373-2386.","journal-title":"Int J Cardiol"},{"key":"null","doi-asserted-by":"crossref","first-page":"542","DOI":"10.14348\/molcells.2017.0012","volume":"40","author":"Long B","year":"2017","unstructured":"Long B, Gan TY, Zhang RC, Zhang YH. miR-23a regulates cardiomyocyte apoptosis by targeting manganese superoxide dismutase. Mol Cell, 2017, 40: 542-549.","journal-title":"Mol Cell"},{"key":"null","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s10495-017-1388-9","volume":"22","author":"Hohensinner PJ","year":"2017","unstructured":"Hohensinner PJ, Takacs N, Kaun C, Thaler B, Krychtiuk KA, Pfaffenberger S, Aliabadi A. Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction. Apoptosis, 2017, 22: 1048-1055.","journal-title":"Apoptosis"},{"key":"null","doi-asserted-by":"crossref","first-page":"521742","DOI":"10.1155\/2011\/521742","volume":"2011","author":"Harston RK","year":"2011","unstructured":"Harston RK, Kuppuswamy D. Integrins are the necessary links to hypertrophic growth in cardiomyocytes. J Signal Transduct, 2011, 2011:","journal-title":"J Signal Transduct"},{"key":"null","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/cbin.10777","volume":"41","author":"Befani C","year":"2017","unstructured":"Befani C, Liakos P. Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary-like tube formation. Cell Biol Int, 2017, 41: 769-778.","journal-title":"Cell Biol Int"},{"key":"null","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/01.RES.0000252291.88540.ac","volume":"99","author":"Valencik ML","year":"2006","unstructured":"Valencik ML, Zhang D, Punske B, Hu P, McDonald JA, Litwin SE. Integrin activation in the heart: a link between electrical and contractile dysfunction?. Circ Res, 2006, 99: 1403-1410.","journal-title":"Circ Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1139\/Y09-131","volume":"88","author":"Shewchuk LJ","year":"2010","unstructured":"Shewchuk LJ, Bryan S, Ulanova M, Khaper N. Integrin beta3 prevents apoptosis of HL-1 cardiomyocytes under conditions of oxidative stress. Can J Physiol Pharmacol, 2010, 88: 324-330.","journal-title":"Can J Physiol Pharmacol"},{"key":"null","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.yexcr.2016.05.015","volume":"346","author":"Nair MG","year":"2016","unstructured":"Nair MG, Desai K, Prabhu JS, Hari PS, Remacle J, Sridhar TS. beta3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD. Exp Cell Res, 2016, 346: 137-145.","journal-title":"Exp Cell Res"},{"key":"null","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1096\/fj.08-127480","volume":"23","author":"Johnston RK","year":"2009","unstructured":"Johnston RK, Balasubramanian S, Kasiganesan H, Baicu CF, Zile MR, Kuppuswamy D. Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEB J, 2009, 23: 2759-2771.","journal-title":"FASEB J"}],"container-title":["Acta Biochimica et Biophysica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/9F54C5087C5C4DC5A491300672D4F31B","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmy056","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/engine.scichina.com\/doi\/pdf\/9F54C5087C5C4DC5A491300672D4F31B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T10:22:54Z","timestamp":1661077374000},"score":1,"resource":{"primary":{"URL":"http:\/\/engine.scichina.com\/doi\/10.1093\/abbs\/gmy056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,1]]},"references-count":21,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,5,23]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/abbs\/gmy056","relation":{},"ISSN":["1672-9145"],"issn-type":[{"value":"1672-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,1]]}}}