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However, our knowledge of the mechanisms underlying the relationship between diabetes and physical inactivity is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To investigate the associations between diabetes and the levels and evolution of physical activity across aging, and to determine whether physical, emotional, and cognitive factors mediate these associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from 105,622 adults aged 50\u201396 years from the Survey of Health, Ageing and Retirement in Europe (SHARE) were used in adjusted linear mixed models to examine whether diabetes was associated with physical activity levels and variations across aging. The potential mediators were subjective energy, muscle strength, physical and cognitive disability, sleep problems, depressive symptoms, and cognitive functions. The variables were measured up to seven times over a 13-year period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Individuals with diabetes demonstrated a lower level and a steeper decrease in physical activity across aging than individual without diabetes. Mediators explained ~53% and 94% of the association of diabetes with the level of physical activity and with the linear evolution of physical activity across aging, respectively. All mediators were significantly associated with physical activity. Physical and cognitive disability as well as depressive symptoms were the strongest mediators, while sleep was the lowest one.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggest that the etiology of physical inactivity in individuals with diabetes can result from several physical, emotional, and cognitive changes associated with the emergence of this disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/abm\/kaaa120","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T05:22:49Z","timestamp":1611552169000},"page":"904-917","source":"Crossref","is-referenced-by-count":24,"title":["Why Are Individuals With Diabetes Less Active? The Mediating Role of Physical, Emotional, and Cognitive Factors"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-4673","authenticated-orcid":false,"given":"Boris","family":"Cheval","sequence":"first","affiliation":[{"name":"Swiss Center for Affective Sciences, University of Geneva, Switzerland"},{"name":"Laboratory for the Study of Emotion Elicitation and Expression (E3Lab), Department of Psychology, University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-0599","authenticated-orcid":false,"given":"Silvio","family":"Maltagliati","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, SENS, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sieber","sequence":"additional","affiliation":[{"name":"Swiss NCCR \u201cLIVES \u2013 Overcoming Vulnerability: Life Course Perspectives,\u201d University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beran","sequence":"additional","affiliation":[{"name":"Division of Tropical and Humanitarian Medicine, University of Geneva and Geneva University Hospitals, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efna","family":"Chalabaev","sequence":"additional","affiliation":[{"name":"Univ. 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