{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:33:13Z","timestamp":1779089593753,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA218723"],"award-info":[{"award-number":["R21CA218723"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["TR002535"],"award-info":[{"award-number":["TR002535"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral anti-cancer treatments such as adjuvant endocrine therapies (AET) for breast cancer survivors are commonly used but adherence is a challenge. Few low-touch, scalable interventions exist to increase ET adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the acceptability, feasibility, and initial efficacy of a low-touch, remotely-delivered values plus AET education intervention (REACH) to promote AET adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A mixed-methods trial randomized 88 breast cancer survivors 1:1 to REACH or Education alone. Wisepill real-time electronic adherence monitoring tracked monthly AET adherence during a 1-month baseline through 6-month follow-up (FU) (primary outcome). Patient-reported outcomes were evaluated through 3- and 6-month FU (secondary). Multiple indices of intervention feasibility and acceptability were evaluated. Qualitative exit interviews (n = 38) further assessed participants\u2019 perceptions of feasibility\/acceptability and recommendations for intervention adaptation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The trial showed strong feasibility and acceptability, with an eligible-to-enrolled rate of 85%, 100% completion of the main intervention sessions, and \u201cgood\u201d intervention satisfaction ratings on average. For Wisepill-assessed AET adherence, REACH outperformed Education for Month 1 of FU (p = .027) and not thereafter. Participants in REACH maintained high adherence until Month 4 of FU, whereas in Education, adherence declined significantly in Month 1. Conditions did not differ in self-reported adherence, positive affective attitudes, future intentions, or necessity beliefs. REACH trended toward less negative AET attitudes than Education at 3-month FU (p = .057) reflecting improvement in REACH (p = .004) but not Education (p = .809). Exploratory moderator analyses showed that average to highly positive baseline AET affective attitudes and oncologist-patient communication each predicted higher adherence following REACH than Education; low levels did not. Participants identified recommendations to strengthen the interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>REACH, a low-touch values intervention, showed good feasibility and acceptability, and initial promise in improving objectively-assessed AET adherence among breast cancer survivors (relative to education alone). Future research should target improving REACH\u2019s tailoring and endurance.<\/jats:p><\/jats:sec>","DOI":"10.1093\/abm\/kaab118","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:57:01Z","timestamp":1648159021000},"page":"856-871","source":"Crossref","is-referenced-by-count":30,"title":["Randomized Controlled Pilot Trial of a Low-Touch Remotely-Delivered Values Intervention to Promote Adherence to Adjuvant Endocrine Therapy Among Breast Cancer Survivors"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-095X","authenticated-orcid":false,"given":"Joanna J","family":"Arch","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience, University of Colorado Boulder , 345 UCB Muenzinger, Boulder, CO, 80309-0345 , USA"},{"name":"Division of Cancer Prevention and Control, University of Colorado Cancer Center , Aurora, CO , 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Neuroscience, University of Colorado Boulder , 345 UCB Muenzinger, Boulder, CO, 80309-0345 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill L","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Rocky Mountain Cancer Centers-Boulder , Boulder, CO , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma E","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience, University of Colorado Boulder , 345 UCB Muenzinger, Boulder, CO, 80309-0345 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Albright","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, University of Colorado School of Medicine , Aurora, CO , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica F","family":"Magidson","sequence":"additional","affiliation":[{"name":"Department of Psychology, 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