{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:18:36Z","timestamp":1763572716592,"version":"3.37.3"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA211625"],"award-info":[{"award-number":["R01CA211625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["3P30CA072720","P30CA118100","75N91021D00009"],"award-info":[{"award-number":["3P30CA072720","P30CA118100","75N91021D00009"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["5NU58DP006279"],"award-info":[{"award-number":["5NU58DP006279"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007558","name":"Rutgers Cancer Institute of New Jersey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007558","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Mexico Tumor Registry","award":["HHSN261201800014I","HHSN26100001"],"award-info":[{"award-number":["HHSN261201800014I","HHSN26100001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A theory-guided Tailored Counseling and Navigation (TCN) intervention successfully increased cancer genetic risk assessment (CGRA) uptake among cancer survivors at increased risk of hereditary breast and ovarian cancer (HBOC). Understanding the pathways by which interventions motivate behavior change is important for identifying the intervention\u2019s active components.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>We examined whether the TCN intervention exerted effects on CGRA uptake through hypothesized theoretical mediators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cancer survivors at elevated risk for HBOC were recruited from three statewide cancer registries and were randomly assigned to three arms: TCN (n = 212), Targeted Print (TP, n = 216), and Usual Care (UC, n = 213). Theoretical mediators from the Extended Parallel Process Model, Health Action Planning Approach, and Ottawa Decision Support Framework were assessed at baseline and 1-month follow-up; CGRA uptake was assessed at 6 months. Generalized structural equation modeling was used for mediation analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The TCN effects were most strongly mediated by behavioral intention alone (\u03b2 = 0.49 and 0.31) and by serial mediation through self-efficacy and intention (\u03b2 = 0.041 and 0.10) when compared with UC and TP, respectively. In addition, compared with UC, the TCN also increased CGRA through increased perceived susceptibility, knowledge of HBOC, and response efficacy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Risk communication and behavioral change interventions for hereditary cancer should stress a person\u2019s increased genetic risk and the potential benefits of genetic counseling and testing, as well as bolster efficacy beliefs by helping remove barriers to CGRA. System-level and policy interventions are needed to further expand access.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/abm\/kaad048","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:48:27Z","timestamp":1693658907000},"page":"965-977","source":"Crossref","is-referenced-by-count":2,"title":["Identifying Mediators of Intervention Effects Within a Randomized Controlled Trial to Motivate Cancer Genetic Risk Assessment Among Breast and Ovarian Cancer Survivors"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-3855","authenticated-orcid":false,"given":"Jinghua","family":"An","sequence":"first","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey , New Brunswick, NJ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-En","family":"Lu","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey , New Brunswick, NJ , USA"},{"name":"School of 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