{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:50:13Z","timestamp":1762044613085,"version":"build-2065373602"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U19 CA203654-S"],"award-info":[{"award-number":["U19 CA203654-S"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polygenic risk scores (PRS) hold promise for early lung cancer detection and personalized treatment, yet factors influencing patient interest in PRS-based genetic testing are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Grounded in the health belief model, this mixed-methods study explored knowledge, attitudes, perceived benefits and barriers to lung cancer PRS, and preferences for receiving PRS results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 141 individuals (41% African American, 63% female) recruited from two hospital affiliates of a comprehensive cancer center in the Southwestern United States. Although participants recognized the severity of lung cancer, knowledge of PRS was limited. Concerns about privacy, psychological impacts, and uncertainty about result usefulness diminished interest in genetic testing for polygenic risk. Significant differences (P\u2005&amp;lt;\u2005.05) in attitudes were observed: women expressed heightened concerns about psychological effects, and African Americans reported greater perceptions of stigma and concerns about potential familial consequences. Qualitative findings emphasized the psychological burden of learning one\u2019s genetic risk, particularly among those with family cancer histories or smoking exposure. Participants emphasized the need for clear, actionable results and assurances of data privacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perceived benefits and barriers to PRS-based testing varied by sociodemographic and personal risk factors, with concerns about stigma, psychological burden, and privacy shaping attitudes. Given participants\u2019 emphasis on clear, actionable results, strategies to enhance uptake should improve risk communication, ensure data privacy, and provide guidance on risk-reducing actions. Tailored approaches addressing subgroup-specific concerns may improve diverse patient engagement and equitable access to PRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/abm\/kaaf020","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T15:20:29Z","timestamp":1739287229000},"source":"Crossref","is-referenced-by-count":0,"title":["Attitudes regarding polygenic risk testing for lung cancer: a mixed-methods study"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-9111","authenticated-orcid":false,"given":"Hoda","family":"Badr","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine , Houston, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyoung","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine , Houston, TX ,","place":["United States"]},{"name":"University of New Mexico Comprehensive Cancer Center, Albequerque , NM ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda C","family":"Aldrich","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN ,","place":["United States"]},{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN ,","place":["United States"]},{"name":"Department of Thoracic Surgery, Vanderbilt University Medical Center , Nashville, TN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J","family":"Bierut","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Washington University School of Medicine , St. Louis, MO ,","place":["United States"]},{"name":"Department of Psychiatry,\u00a0Alvin J. 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