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LTL was measured from blood using Southern blot analysis. Built environment measures included unfavorable food stores, population density, PA facilities, and popular walking destinations. Total PA and healthy eating diet scores were tested as mediators. Linear regression was used to examine the direct and indirect associations between each built environment factor and LTL adjusted for covariates. All analyses were stratified by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Unfavorable food stores, population density, PA facilities, and popular walking destinations were directly associated with LTL (\u03b2 = \u2212.05, 95% confidence interval [CI] = \u22120.08 to \u22120.01; \u03b2 = \u2212.06, 95% CI = \u22120.09 to \u22120.02; \u03b2 = \u2212.04, 95% CI = \u22120.07 to \u22120.01; and \u03b2 = \u2212.05, 95% CI = \u22120.08 to \u22120.02, respectively). When stratified by sex, similar associations were observed in females but not in males. No statistically significant mediation through PA or diet was observed in overall or sex-stratified analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Built environment appears to be directly associated with shorter LTL in African American females, suggesting an increased disease risk. Similar studies could be extended to other racial and\/or ethnic groups to determine the generalizability of the current findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/abm\/kaag016","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:49:39Z","timestamp":1774529379000},"source":"Crossref","is-referenced-by-count":0,"title":["Neighborhood built environment and leukocyte telomere length among African American adults in the Jackson Heart Study"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-7111","authenticated-orcid":false,"given":"Mohammad","family":"Moniruzzaman","sequence":"first","affiliation":[{"name":"Socio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health , Bethesda, MD 20892,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-7315","authenticated-orcid":false,"given":"Yangyang","family":"Deng","sequence":"additional","affiliation":[{"name":"Socio-Spatial Determinants of Health (SSDH) Laboratory, Population and Community Health Sciences Branch, Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health , Bethesda, MD 20892,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-8364","authenticated-orcid":false,"given":"Lauren A","family":"Reid","sequence":"additional","affiliation":[{"name":"South College, School of Physician Assistant Studies , Atlanta, GA 30345,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-0038","authenticated-orcid":false,"given":"Allana T","family":"Forde","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health , Bethesda, MD 20892,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7153-5100","authenticated-orcid":false,"given":"Priya","family":"Palta","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4083-8328","authenticated-orcid":false,"given":"Mario","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Population and Public Health, School of Medicine, University of CA , Riverside, CA 92521,","place":["United 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