{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:07:24Z","timestamp":1788890844744,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":237,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["#1129822"],"award-info":[{"award-number":["#1129822"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["#2008454"],"award-info":[{"award-number":["#2008454"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHMRC Synergy","award":["#2009923"],"award-info":[{"award-number":["#2009923"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>In the Melanoma Genomics Managing Your Risk Study, receiving personal genomic risk testing led to improvements in some melanoma prevention and early detection behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to examine the hypothesized psychosocial mediators of the effects observed in the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Australians of European ancestry without melanoma and aged 18-69\u2009years were recruited via the national Medicare database and randomized to receive personal genomic risk information or usual care (N\u2009=\u20091025). Questionnaires were administered at baseline, 1-month post-intervention, and 12-months post-baseline to assess self-reported prevention and early detection behaviors and psychosocial measures. We first evaluated the intervention\u2019s effect on psychosocial measures and the associations between psychosocial measures and behavioral outcomes. We then estimated the natural indirect effects (NIEs) and their 95% confidence intervals (CIs) to quantify the effects mediated by potential mediators identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants with high traditional melanoma risk, the intervention\u2019s effect on increased sun protection at 1 month was partially mediated by changes in the perceived importance (NIE mean difference 0.02; 95% CI: 0.00-0.04) and perceived effectiveness (0.01; 0.00-0.03]) of sun protection strategies. Among women, the intervention\u2019s effect on increased whole-body skin examinations at 1 month was partially mediated by perceived capability to engage in skin examinations (NIE odds ratio 1.08; 95% CI: 1.00-1.29) and perceived control over detecting a future melanoma (1.13; 1.03-1.32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>The effectiveness of precision prevention and early detection interventions may be enhanced by targeting key psychosocial mediators through tailored communication of personal melanoma risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/abm\/kaag046","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:40:51Z","timestamp":1785843651000},"source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial mediators for the impact of personal genomic risk information on melanoma prevention and early detection behaviors"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6102-6234","authenticated-orcid":false,"given":"Sabrina E","family":"Wang","sequence":"first","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW , Sydney 2011,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Espinoza","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW , Sydney 2011,","place":["Australia"]},{"name":"NHMRC Clinical Trials Centre, The University of Sydney , Sydney 2050,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serigne N","family":"Lo","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia, The University of Sydney , Sydney 2065,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia K","family":"Smit","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW , Sydney 2011,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E","family":"Cust","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW , Sydney 2011,","place":["Australia"]},{"name":"Melanoma Institute Australia, The University of Sydney , Sydney 2065,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026090813173201000_kaag046-B1","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1001\/jama.2023.3262","article-title":"Skin cancer screening: updated evidence report and systematic review for the US preventive services task force","volume":"329","author":"Henrikson","year":"2023","journal-title":"JAMA"},{"key":"2026090813173201000_kaag046-B2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1200\/jco.2010.28.7078","article-title":"Reduced melanoma after regular sunscreen use: randomized trial follow-up","volume":"29","author":"Green","year":"2011","journal-title":"J Clin Oncol"},{"key":"2026090813173201000_kaag046-B3","doi-asserted-by":"publisher","first-page":"3976","DOI":"10.1200\/jco.2016.67.5934","article-title":"Sunscreen use and subsequent melanoma risk: a population-based cohort study","volume":"34","author":"Ghiasvand","year":"2016","journal-title":"J Clin Oncol"},{"key":"2026090813173201000_kaag046-B4","volume-title":"Clinical Practice Guidelines for the Diagnosis and Management of Melanoma","author":"Cancer Council Australia Melanoma Guidelines Working Party","year":"2024"},{"key":"2026090813173201000_kaag046-B5","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1038\/s41436-021-01292-w","article-title":"Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial","volume":"23","author":"Smit","year":"2021","journal-title":"Genet Med"},{"key":"2026090813173201000_kaag046-B6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/00223980.1975.9915803","article-title":"A protection motivation theory of fear appeals and attitude change","volume":"91","author":"Rogers","year":"1975","journal-title":"J Psychol"},{"key":"2026090813173201000_kaag046-B7","volume-title":"Health Behavior: Theory, Research, and Practice","author":"Glanz","year":"2015"},{"key":"2026090813173201000_kaag046-B8","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/bjd.17582","article-title":"Exploring the emotional and behavioural reactions to receiving personalized melanoma genomic risk information: a qualitative study","volume":"180","author":"Fenton","year":"2019","journal-title":"Br J Dermatol"},{"key":"2026090813173201000_kaag046-B9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1186\/s13063-020-04351-w","article-title":"The melanoma genomics managing your risk study randomised controlled trial: statistical analysis plan","volume":"21","author":"Lo","year":"2020","journal-title":"Trials"},{"key":"2026090813173201000_kaag046-B10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cct.2018.05.014","article-title":"The melanoma genomics managing your risk study: a protocol for a randomized controlled trial evaluating the impact of personal genomic risk information on skin cancer prevention behaviors","volume":"70","author":"Smit","year":"2018","journal-title":"Contemp Clin Trials"},{"key":"2026090813173201000_kaag046-B11","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"2026090813173201000_kaag046-B12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1001\/archdermatol.2007.46","article-title":"Measures of sun exposure and sun protection practices for behavioral and epidemiologic research","volume":"144","author":"Glanz","year":"2008","journal-title":"Arch Dermatol"},{"key":"2026090813173201000_kaag046-B13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S1930297500000334","article-title":"A domain-specific risk-taking (DOSPERT) scale for adultpopulations","volume":"1","author":"Blais","year":"2006","journal-title":"Judgm Decis Mak"},{"key":"2026090813173201000_kaag046-B14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.canep.2019.05.002","article-title":"Risk attitudes and sun protection behaviour: can behaviour be altered by using a melanoma genomic risk intervention?","volume":"61","author":"Morton","year":"2019","journal-title":"Cancer Epidemiol"},{"key":"2026090813173201000_kaag046-B15","volume-title":"Stata Statistical Software: Release 19","author":"StataCorp","year":"2025"},{"key":"2026090813173201000_kaag046-B16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-publhealth-032315-021402","article-title":"Mediation analysis: a practitioner\u2019s guide","volume":"37","author":"VanderWeele","year":"2016","journal-title":"Annu Rev Public Health"},{"key":"2026090813173201000_kaag046-B17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ypmed.2017.08.029","article-title":"College tanning behaviors, attitudes, beliefs, and intentions: a systematic review of the literature","volume":"105","author":"Gambla","year":"2017","journal-title":"Prev Med"},{"key":"2026090813173201000_kaag046-B18","doi-asserted-by":"publisher","first-page":"114093","DOI":"10.1016\/j.fct.2023.114093","article-title":"Application habits and practices of regular sunscreen users in the United States: results of an online survey","volume":"181","author":"Norman","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"2026090813173201000_kaag046-B19","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/hpja.301","article-title":"Unintended sunburn after sunscreen application: an exploratory study of sun protection","volume":"31","author":"O\u2019Hara","year":"2020","journal-title":"Health Promot J Austr"},{"key":"2026090813173201000_kaag046-B20","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3390\/jpm12101581","article-title":"Communicating personal melanoma polygenic risk information: participants\u2019 experiences of genetic counseling in a community-based study","volume":"12","author":"Smit","year":"2022","journal-title":"J Pers Med"},{"key":"2026090813173201000_kaag046-B21","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/gim.2014.37","article-title":"Unaffected family members report improvements in daily routine sun protection 2 years following melanoma genetic testing","volume":"16","author":"Aspinwall","year":"2014","journal-title":"Genet Med"},{"key":"2026090813173201000_kaag046-B22","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jaad.2008.12.034","article-title":"Patterns of photoprotection following CDKN2A\/p16 genetic test reporting and counseling","volume":"60","author":"Aspinwall","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"2026090813173201000_kaag046-B23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1158\/1055-9965.Epi-12-1174","article-title":"Melanoma genetic testing, counseling, and adherence to skin cancer prevention and detection behaviors","volume":"22","author":"Glanz","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026090813173201000_kaag046-B24","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/pcmr.13106","article-title":"Melanoma literacy among the general population of three Western US states","volume":"36","author":"Leachman","year":"2023","journal-title":"Pigment Cell Melanoma Res"},{"key":"2026090813173201000_kaag046-B25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/pon.3476","article-title":"Improving subjective perception of personal cancer risk: systematic review and meta-analysis of educational interventions for people with cancer or at high risk of cancer","volume":"23","author":"Dieng","year":"2014","journal-title":"Psychooncology"}],"container-title":["Annals of Behavioral Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/abm\/article-pdf\/60\/1\/kaag046\/70805628\/kaag046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/abm\/article-pdf\/60\/1\/kaag046\/70805628\/kaag046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:17:38Z","timestamp":1788887858000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/abm\/article\/doi\/10.1093\/abm\/kaag046\/8771077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/abm\/kaag046","relation":{},"ISSN":["1532-4796"],"issn-type":[{"value":"1532-4796","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"kaag046"}}