{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:34:41Z","timestamp":1791394481401,"version":"4.3.3"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"name":"Department of Defense, through the Pain Management Collaboratory\u2013Pragmatic Clinical Trials Demonstration","award":["W81XWH-18-2-0003"],"award-info":[{"award-number":["W81XWH-18-2-0003"]}]},{"name":"National Center for Complementary and Integrative Health","id":[{"id":"https:\/\/ror.org\/00190t495","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Office of Behavioral and Social Sciences Research"},{"name":"National Institute of Alcohol Abuse and Alcoholism","id":[{"id":"https:\/\/ror.org\/02jzrsm59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Office of Disease Prevention","id":[{"id":"https:\/\/ror.org\/046zezr58","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Neurological Disorders and Stroke","id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Helping End Addiction Longterm"},{"name":"VA Career Research Scientist Award","award":["RCS 23-082"],"award-info":[{"award-number":["RCS 23-082"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Mindfulness meditation is an evidence-based therapy for chronic pain for which some have explored possible mechanisms of action. However, these mechanisms can vary widely depending on the mindfulness-based intervention (MBI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study possible mechanisms of action of 2 similar MBIs for pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We used data from our learning to apply mindfulness to pain (LAMP) pragmatic randomized controlled trial comparing usual care with virtual group or self-paced MBIs. The LAMP MBIs included education on adaptive pain behaviors and mindfulness and used shorter, less formal mindfulness practice than standard MBIs. We examined whether mindfulness, pain self-efficacy, pain catastrophizing, and stress mediated the treatment effects on 2 pain and 7 pain-related biopsychosocial outcomes at 10 weeks and 6 months using mediation models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MBIs improved pain catastrophizing, pain self-efficacy, and mindfulness but did not affect perceived stress. Pain catastrophizing and pain self-efficacy had large mediating effects between the MBIs and pain interference, pain intensity, physical functioning, social functioning, anxiety, fatigue, sleep disturbance, depression, and post-traumatic stress disorder. mindfulness also mediated the above relationships with smaller effects between MBIs and all outcomes except for pain interference, pain intensity, physical functioning, and social functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced pain catastrophizing and increased pain self-efficacy were apparent mechanisms of action improving pain interference, pain intensity, and other biopsychosocial outcomes in our MBIs, whereas increased mindfulness was the apparent mechanism of action improving psychological and sleep-related outcomes. This study improves our understanding of mechanisms by which MBIs can affect pain and important pain-related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study registration and analytic plan registration<\/jats:title>\n                    <jats:p>clinicaltrials.gov. Identifier: NCT04526158.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/abm\/kaag061","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:35:39Z","timestamp":1788521739000},"source":"Crossref","is-referenced-by-count":0,"title":["Psychological factors as mediators of the effectiveness of telehealth mindfulness-based interventions for pain and pain-related conditions"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-1132","authenticated-orcid":false,"given":"Stephanie L","family":"Taylor","sequence":"first","affiliation":[{"name":"VA Health Systems Research Center for the Study of Healthcare Innovation, Implementation and Policy, Greater Los Angeles VA Health Care System , Los Angeles, CA 90073,","place":["United States"]},{"name":"Department of Medicine, David Geffen School of Medicine, University of California , Los Angeles, CA 90095,","place":["United States"]},{"name":"Department of Health 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