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This comorbidity is associated with poorer self-management, worse disease outcomes, and higher mortality. Syndemic theory is a novel social epidemiological framework that emphasizes the role of economic and social adversity in promoting disease comorbidity and health disparities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Informed by the syndemic framework, this study explored associations of socioeconomic and psychosocial adversity (low income\/education, trauma history, adverse childhood experiences, ethnic discrimination, neighborhood problems [e.g., violence]) with comorbidity of diabetes and depression symptoms in the Hispanic Community Health Study\/Study of Latinos (HCHS\/SOL) and Sociocultural Ancillary Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 5,247 Latino adults, aged 18\u201374, enrolled in four U.S. cities from 2008 to 2011. Participants completed a baseline physical exam and measures of depression symptoms and psychosocial adversity. Multinomial logistic regression analyses were conducted to examine associations of adversity variables with comorbid diabetes and high depression symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Household income below $30,000\/year was associated with higher odds of diabetes\/depression comorbidity (odds ratio [OR] = 4.61; 95% confidence interval [CI]: 2.89, 7.33) compared to having neither condition, as was each standard deviation increase in adverse childhood experiences (OR = 1.41; 95% CI: 1.16, 1.71), ethnic discrimination (OR = 1.23; 95% CI: 1.01, 1.50), and neighborhood problems (OR = 1.53; 95% CI: 1.30, 1.80).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low household income, adverse childhood experiences, ethnic discrimination, and neighborhood problems are related to comorbid diabetes and depression in U.S. Latinos. Future studies should explore these relationships longitudinally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/abm\/kaz009","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T15:10:17Z","timestamp":1554477017000},"page":"975-987","source":"Crossref","is-referenced-by-count":38,"title":["Association of Social Adversity with Comorbid Diabetes and Depression Symptoms in the Hispanic Community Health Study\/Study of Latinos Sociocultural Ancillary Study: A Syndemic Framework"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-5608","authenticated-orcid":false,"given":"Jessica L","family":"McCurley","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela P","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Joint Doctoral Program in Clinical Psychology, San Diego State University\/University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia I","family":"Bravin","sequence":"additional","affiliation":[{"name":"Joint Doctoral Program in Clinical Psychology, San Diego State University\/University of California San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Schneiderman","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami, Coral Gables, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha A","family":"Reina","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami, Coral Gables, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasneem","family":"Khambaty","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami, Coral Gables, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila F","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, San Diego State University, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L","family":"Daviglus","sequence":"additional","affiliation":[{"name":"Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA"},{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes R","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen R","family":"Isasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M","family":"Perreira","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A","family":"Talavera","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, San 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