{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:09:16Z","timestamp":1778321356849,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH Small Business Innovative Research","award":["75N93022C00011"],"award-info":[{"award-number":["75N93022C00011"]}]},{"name":"NIH Small Business Innovative Research","award":["75N93022C00020"],"award-info":[{"award-number":["75N93022C00020"]}]},{"name":"NIH\/NIAID","award":["R21AI168929"],"award-info":[{"award-number":["R21AI168929"]}]},{"name":"NIH\/NIAID","award":["5R21AI173995"],"award-info":[{"award-number":["5R21AI173995"]}]},{"name":"Base&Byte Biotechnology Co., Ltd"},{"DOI":"10.13039\/100010519","name":"Louisiana State University Health Sciences Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010519","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007681","name":"Florida International University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Active immunization (vaccination) induces long-lasting immunity with memory, which takes weeks to months to develop. Passive immunization (transfer of neutralizing antibodies) provides immediate protection, yet with high cost and effects being comparatively short-lived. No currently approved adjuvants are compatible with formulations to combine active and passive immunizations, not to mention their huge disparities in administration routes and dosage. To solve this, we engineered the Fc fragment of human IgG1 into a hexamer nanoparticle and expressed its afucosylated form in Fut8\u2212\/\u2212 CHO cells, naming it \u201cFcRider.\u201d FcRider is highly soluble with long-term stability, easily produced at high levels equivalent to those of therapeutic antibodies, and is amenable to conventional antibody purification schemes. Most importantly, FcRider possesses endogenous adjuvant activities. Using SWHEL B cell receptor (BCR) transgenic mice, we found that HEL-FcRider induced GL7+ germinal center B cells and HEL-specific IgG. Similarly, immunizing mice with UFO-BG-FcRider, a fusion containing the stabilized human immunodeficiency virus-1 (HIV-1) Env protein as immunogen, promoted somatic hypermutation and generation of long CDR3 of the IgG heavy chains. Intramuscular injection of (Fba\u00a0+\u00a0Met6)3-FcRider, a fusion with two peptide epitopes from Candida albicans cell surface, stimulated strong antigen-specific IgG titers. In three different models, we showed that afucosylated FcRider functions as a multivalent immunogen displayer and stimulates antigen-specific B cells without any exogenous adjuvant. As an antibody derivative, afucosylated FcRider could be a novel platform combining vaccines and therapeutic antibodies, integrating active and passive immunizations into single-modality \u201chybrid immunization\u201d to provide complete and long-lasting protection against infections, and may open new avenues in cancer immunotherapy as well.<\/jats:p>","DOI":"10.1093\/abt\/tbae023","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T19:13:49Z","timestamp":1724354029000},"page":"295-306","source":"Crossref","is-referenced-by-count":1,"title":["FcRider: a recombinant Fc nanoparticle with endogenous adjuvant activities for hybrid immunization"],"prefix":"10.1093","volume":"7","author":[{"given":"Changchuin","family":"Mao","sequence":"first","affiliation":[{"name":"Antagen Pharmaceuticals, Inc. , Canton, MA 02021,","place":["United 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