{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:37Z","timestamp":1787008297497,"version":"build-2736575974"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The overuse of antibiotics worldwide, especially during the Coronavirus pandemic, has raised concerns about the rise of antibiotic resistance and its side effects. Immunoglobulin Y, a natural protein that specifically targets foreign antigens, holds promise as a potential therapeutic option, particularly for individuals with sensitive immune systems. Despite numerous studies on IgY, the optimal administration method, effective dose, target antigen, and potential side effects of this antibody remain areas of active research and challenge. This review selected and evaluated articles published in the last ten years from databases such as PubMed and Science Direct with appropriate keywords discussing the therapeutic effects of immunoglobulin Y in human infections in vivo. Out of all the reviewed articles, 35 articles met the inclusion criteria. The results showed that the specific antibody against dental, respiratory, and skin infections has an acceptable effectiveness. In contrast, some infections, such as neurological infections, including tetanus and botulism, still need further investigation due to the short survival time of mice. On the other hand, reporting side effects such as antibody-dependent enhancement in some infections limits its use.<\/jats:p>","DOI":"10.1093\/abt\/tbaf007","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T15:20:43Z","timestamp":1741188043000},"page":"111-123","source":"Crossref","is-referenced-by-count":2,"title":["A systematic review of the avian antibody (IgY) therapeutic effects on human bacterial infections over the decade"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-7471","authenticated-orcid":false,"given":"Zahra","family":"Esmaeili","sequence":"first","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]},{"name":"Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kamal Shahsavar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]},{"name":"Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiarash","family":"Ghazvini","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]},{"name":"Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences , Mashhad 9177949025 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,9]]},"reference":[{"key":"2026050905020285700_ref1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040196","article-title":"Trends, epidemiology, and management of multi-drug resistant gram-negative bacterial infections in the hospitalized setting","volume":"9","author":"Morris","year":"2020","journal-title":"Antibiotics (Basel, Switzerland)"},{"key":"2026050905020285700_ref2","doi-asserted-by":"publisher","first-page":"V9","DOI":"10.1007\/s00415-006-5002-2","article-title":"Immunoglobulins\u2014basic considerations","volume":"253","author":"Mix","year":"2006","journal-title":"J Neurol"},{"key":"2026050905020285700_ref3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1203\/PDR.0b013e3180686ce0","article-title":"Atypical measles and enhanced respiratory syncytial virus disease (ERD) made simple","volume":"62","author":"Polack","year":"2007","journal-title":"Pediatr Res"},{"key":"2026050905020285700_ref4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/BF02284479","article-title":"Ueber die specifische Bedeutung der Choleraimmunit\u00e4t","volume":"17","author":"Pfeiffer","year":"1894","journal-title":"Z Hyg Infektionskr"},{"key":"2026050905020285700_ref5","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1073\/pnas.0637469100","article-title":"Antibody-enhanced pneumococcal adherence requires IgA1 protease","volume":"100","author":"Weiser","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026050905020285700_ref6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1124\/jpet.118.253617","article-title":"Antibody dependent enhancement of Acinetobacter baumannii infection in a mouse pneumonia model","volume":"368","author":"Wang-Lin","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"2026050905020285700_ref7","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1084\/jem.20132444","article-title":"Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing","volume":"211","author":"Wells","year":"2014","journal-title":"J Exp Med"},{"key":"2026050905020285700_ref8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1172\/JCI116190","article-title":"Antibody to Rmp (outer membrane protein 3) increases susceptibility to gonococcal infection","volume":"91","author":"Plummer","year":"1993","journal-title":"J Clin Invest"},{"key":"2026050905020285700_ref9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet (London, England)"},{"key":"2026050905020285700_ref10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/19424396.2003.12224145","article-title":"Acquisition and transmission of mutans streptococci","volume":"31","author":"Berkowitz","year":"2003","journal-title":"J Calif Dent Assoc"},{"key":"2026050905020285700_ref11","doi-asserted-by":"publisher","first-page":"308","DOI":"10.2174\/1874210601610010308","article-title":"Biological and immunogenicity property of IgY anti S. mutans ComD","volume":"10","author":"Bachtiar","year":"2016","journal-title":"Open Dent J"},{"key":"2026050905020285700_ref12","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1128\/AEM.71.5.2372-2380.2005","article-title":"LuxS-based signaling affects Streptococcus mutans biofilm formation","volume":"71","author":"Yoshida","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"2026050905020285700_ref13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1556\/030.63.2016.2.2","article-title":"Effect of topical anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface","volume":"63","author":"Bachtiar","year":"2016","journal-title":"Acta Microbiol Immunol Hung"},{"key":"2026050905020285700_ref14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/prd.12074","article-title":"Periodontal microbiology in Latin America","volume":"67","author":"Contreras","year":"2015","journal-title":"Periodontology"},{"key":"2026050905020285700_ref15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1600-051X.2010.01681.x","article-title":"Periodontal infections: understanding the complexity--consensus of the Seventh European Workshop on Periodontology","volume":"38","author":"Sanz","year":"2011","journal-title":"J Clin Periodontol"},{"key":"2026050905020285700_ref16","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1128\/AAC.47.4.1443-1446.2003","article-title":"Antibiotic resistance in bacteria isolated from subgingival plaque in a Norwegian population with refractory marginal periodontitis","volume":"47","author":"Handal","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"2026050905020285700_ref17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5051\/jpis.2018.48.1.47","article-title":"Clinical and microbiological effects of egg yolk antibody against Porphyromonas gingivalis as an adjunct in the treatment of moderate to severe chronic periodontitis: a randomized placebo-controlled clinical trial","volume":"48","author":"Xu","year":"2018","journal-title":"J Periodont Implant Sci"},{"key":"2026050905020285700_ref18","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/JPER.18-0037","article-title":"Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional nonsurgical therapy in periodontitis patients: a randomized controlled clinical trial","volume":"89","author":"Nguyen","year":"2018","journal-title":"J Periodontol"},{"key":"2026050905020285700_ref19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4014\/jmb.1810.10044","article-title":"Effect of IgY on periodontitis and halitosis induced by Fusobacterium nucleatum","volume":"29","author":"Wang","year":"2019","journal-title":"J Microbiol Biotechnol"},{"key":"2026050905020285700_ref20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1600-051X.1986.tb01471.x","article-title":"Gingivitis","volume":"13","author":"Page","year":"1986","journal-title":"J Clin Periodontol"},{"key":"2026050905020285700_ref21","doi-asserted-by":"publisher","first-page":"e0020322","DOI":"10.1128\/jb.00203-22","article-title":"Insertional inactivation and gene complementation of Prevotella intermedia type IX secretion system reveals its indispensable roles in black pigmentation, hemagglutination, protease activity of Interpain a, and biofilm formation","volume":"204","author":"Naito","year":"2022","journal-title":"J Bacteriol"},{"key":"2026050905020285700_ref22","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1111\/jam.12419","article-title":"Protective effect of an egg yolk-derived immunoglobulin (IgY) against Prevotella intermedia-mediated gingivitis","volume":"116","author":"Hou","year":"2014","journal-title":"J Appl Microbiol"},{"key":"2026050905020285700_ref23","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1021\/mp900056g","article-title":"Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use","volume":"6","author":"Jain","year":"2009","journal-title":"Mol Pharm"},{"key":"2026050905020285700_ref24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/NSA.S133415","article-title":"Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa","volume":"10","author":"Salomoni","year":"2017","journal-title":"Nanotechnol Sci Appl"},{"key":"2026050905020285700_ref25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.molimm.2019.10.005","article-title":"Anti-PcrV IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound models","volume":"116","author":"Ranjbar","year":"2019","journal-title":"Mol Immunol"},{"key":"2026050905020285700_ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7840631","article-title":"Immunotherapy with IgY antibodies toward outer membrane protein F protects burned mice against Pseudomonas aeruginosa infection","volume":"2020","author":"Norouzi","year":"2020","journal-title":"J Immunol Res"},{"key":"2026050905020285700_ref27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.molimm.2021.06.002","article-title":"Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode","volume":"136","author":"Ahmadi","year":"2021","journal-title":"Mol Immunol"},{"key":"2026050905020285700_ref28","first-page":"1","article-title":"Deaths: Leading causes for 2014. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics","volume":"65","author":"Heron","year":"2016","journal-title":"National Vital Statistics System"},{"key":"2026050905020285700_ref29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jcf.2015.08.002","article-title":"Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model","volume":"15","author":"Thomsen","year":"2016","journal-title":"J Cystic Fibrosis"},{"key":"2026050905020285700_ref30","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1128\/IAI.02970-14","article-title":"Anti-Pseudomonas aeruginosa IgY antibodies induce specific bacterial aggregation and internalization in human polymorphonuclear neutrophils","volume":"83","author":"Thomsen","year":"2015","journal-title":"Infect Immun"},{"key":"2026050905020285700_ref31","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1080\/21645515.2016.1145848","article-title":"Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils","volume":"12","author":"Thomsen","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"2026050905020285700_ref32","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/s41598-021-81356-8","article-title":"Specific egg yolk immunoglobulin as a promising non-antibiotic biotherapeutic product against Acinetobacter baumannii pneumonia infection","volume":"11","author":"Jahangiri","year":"2021","journal-title":"Sci Rep"},{"key":"2026050905020285700_ref33","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/jam.14135","article-title":"Specific egg yolk antibodies (IgY) confer protection against Acinetobacter baumannii in a murine pneumonia model","volume":"126","author":"Jahangiri","year":"2019","journal-title":"J Appl Microbiol"},{"key":"2026050905020285700_ref34","doi-asserted-by":"publisher","first-page":"12576","DOI":"10.1038\/s41598-022-16894-w","article-title":"Specific egg yolk antibody raised to biofilm associated protein (Bap) is protective against murine pneumonia caused by Acinetobacter baumannii","volume":"12","author":"Ranjbar","year":"2022","journal-title":"Sci Rep"},{"key":"2026050905020285700_ref35","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/aas.13784","article-title":"Bronchially instilled IgY-antibodies did not decrease pulmonary P. aeruginosa concentration in experimental porcine pneumonia","volume":"65","author":"Otterbeck","year":"2021","journal-title":"Acta Anaesthesiol Scand"},{"key":"2026050905020285700_ref36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molimm.2022.06.010","article-title":"Immunoprotective characterization of egg yolk immunoglobulin raised to loop 3 of outer membrane protein 34 (Omp34) in a murine model against Acinetobacter baumannii","volume":"149","author":"Mesbahi Moghaddam","year":"2022","journal-title":"Mol Immunol"},{"key":"2026050905020285700_ref37","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.24.30550","article-title":"Botulism in Italy, 1986 to 2015","volume":"22","author":"Anniballi","year":"2017","journal-title":"Euro Surveill"},{"key":"2026050905020285700_ref38","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1586\/14787210.2014.945917","article-title":"New targets in the search for preventive and therapeutic agents for botulism","volume":"12","author":"Anniballi","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2026050905020285700_ref39","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.4161\/hv.29433","article-title":"Preparation of egg yolk antibodies against BoNT\/B and their passive protection in mouse models","volume":"10","author":"You","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"2026050905020285700_ref40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1684\/pnv.2015.0529","article-title":"Management and new current French recommendations for tetanus care","volume":"13","author":"Nicolai","year":"2015","journal-title":"Geriatrie et psychologie neuropsychiatrie du vieillissement"},{"key":"2026050905020285700_ref41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1542\/pir.2017-0238","article-title":"Tetanus disease, treatment, management","volume":"39","author":"Rhinesmith","year":"2018","journal-title":"Pediatr Rev"},{"key":"2026050905020285700_ref42","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/15321819.2022.2138718","article-title":"Production of anti-tetanus toxin IgY and study of its protective effects in a mouse model","volume":"44","author":"Mohammadi","year":"2023","journal-title":"J Immunoassay Immunochem"},{"key":"2026050905020285700_ref43","doi-asserted-by":"publisher","first-page":"589","DOI":"10.12688\/f1000research.18093.1","article-title":"Combating cholera","volume":"8","author":"Hsueh","year":"2019","journal-title":"F1000Res"},{"key":"2026050905020285700_ref44","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1080\/20469047.2017.1409452","article-title":"Guidelines for the management of paediatric cholera infection: a systematic review of the evidence","volume":"38","author":"Williams","year":"2018","journal-title":"Paediatr Int Child Health"},{"key":"2026050905020285700_ref45","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jnma.2017.04.001","article-title":"Anti-Vibriocholerae IgY antibody inhibits mortality in suckling mice model","volume":"110","author":"Akbari","year":"2018","journal-title":"J Natl Med Assoc"},{"key":"2026050905020285700_ref46","first-page":"47","article-title":"Production of chicken egg yolk antibody (IgY) against recombinant cholera toxin B subunit and evaluation of its prophylaxis potency in mice","volume":"15","author":"Barati","year":"2018","journal-title":"Iran J Immunol"},{"key":"2026050905020285700_ref47","doi-asserted-by":"publisher","first-page":"107054","DOI":"10.1016\/j.intimp.2020.107054","article-title":"Protective effects of egg yolk immunoglobulins (IgYs) developed against recombinant immunogens CtxB, OmpW and TcpA on infant mice infected with Vibrio cholerae","volume":"89","author":"Taheri","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"2026050905020285700_ref48","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.intimp.2016.04.036","article-title":"Chicken egg yolk antibodies (IgY) modulate the intestinal mucosal immune response in a mouse model of Salmonella typhimurium infection","volume":"36","author":"Li","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"2026050905020285700_ref49","doi-asserted-by":"publisher","first-page":"662710","DOI":"10.3389\/fcimb.2021.662710","article-title":"Chicken egg yolk antibody (IgY) protects mice against enterotoxigenic Escherichia coli infection through improving intestinal health and immune response","volume":"11","author":"Han","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2026050905020285700_ref50","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/jam.12525","article-title":"Chicken egg yolk immunoglobulin (IgY) developed against fusion protein LTB-STa-STb neutralizes the toxicity of Escherichia coli heat-stable enterotoxins","volume":"117","author":"You","year":"2014","journal-title":"J Appl Microbiol"},{"key":"2026050905020285700_ref51","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/1348-0421.12197","article-title":"Evaluation of Shiga toxin 2e-specific chicken egg yolk immunoglobulin: production and neutralization activity","volume":"58","author":"Arimitsu","year":"2014","journal-title":"Microbiol Immunol"},{"key":"2026050905020285700_ref52","first-page":"6430","article-title":"Preparation of specific anti-Helicobacter pylori yolk antibodies and their antibacterial effects","volume":"7","author":"Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"2026050905020285700_ref53","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.vaccine.2017.11.082","article-title":"Preventive effect of anti-VacA egg yolk immunoglobulin (IgY) on Helicobacter pylori-infected mice","volume":"36","author":"Hong","year":"2018","journal-title":"Vaccine"},{"key":"2026050905020285700_ref54","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10096-019-03539-6","article-title":"Clostridium difficile infection: review","volume":"38","author":"Czepiel","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2026050905020285700_ref55","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3389\/fcimb.2017.00365","article-title":"Characterization of chicken IgY specific to Clostridium difficile R20291 spores and the effect of oral administration in mouse models of initiation and recurrent disease","volume":"7","author":"Pizarro-Guajardo","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"2026050905020285700_ref56","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1177\/003335490712200205","article-title":"Estimating health care-associated infections and deaths in U.S. hospitals, 2002","volume":"122","author":"Klevens","year":"2007","journal-title":"Public Health Rep"},{"key":"2026050905020285700_ref57","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1093\/jac\/dkv043","article-title":"Surveillance of antibiotic susceptibility of urinary tract pathogens for a population of 5.6 million over 4 years","volume":"70","author":"Ironmonger","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2026050905020285700_ref58","doi-asserted-by":"publisher","first-page":"988386","DOI":"10.3389\/fmicb.2022.988386","article-title":"Chicken IgY reduces the risk of Pseudomonas aeruginosa urinary tract infections in a murine model","volume":"13","author":"Schwartz","year":"2022","journal-title":"Front Microbiol"},{"key":"2026050905020285700_ref59","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.jmii.2011.12.009","article-title":"Risk factors and clinical outcomes of patients with carbapenem-resistant Acinetobacter baumannii bacteremia","volume":"45","author":"Huang","year":"2012","journal-title":"J Microbiol Immunol Infect"},{"key":"2026050905020285700_ref60","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.biopha.2017.09.112","article-title":"Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii","volume":"95","author":"Shi","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"2026050905020285700_ref61","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/2211-5463.12571","article-title":"Intact anti-LPS IgY is found in the blood after intragastric administration in mice","volume":"9","author":"Zhou","year":"2019","journal-title":"FEBS Open Bio"},{"key":"2026050905020285700_ref62","doi-asserted-by":"publisher","DOI":"10.1242\/bio.032821","article-title":"Anti-lipopolysaccharide egg yolk antibodies enhance the phagocytosis of mammalian phagocytes","volume":"7","author":"Zhou","year":"2018","journal-title":"Biol Open"},{"key":"2026050905020285700_ref63","doi-asserted-by":"publisher","first-page":"28224","DOI":"10.3402\/iee.v5.28224","article-title":"A trial with IgY chicken antibodies to eradicate faecal carriage of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamases","volume":"5","author":"Jonsson","year":"2015","journal-title":"Infect Ecol Epidemiol"},{"key":"2026050905020285700_ref64","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11101432","article-title":"Antimicrobial treatment of Pseudomonas aeruginosa severe sepsis","volume":"11","author":"Zakhour","year":"2022","journal-title":"Antibiotics (Basel, Switzerland)"},{"key":"2026050905020285700_ref65","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.afjem.2020.10.001","article-title":"Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: a prospective observational study","volume":"11","author":"Mulatu","year":"2021","journal-title":"Afr J Emergency Med"},{"key":"2026050905020285700_ref66","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.molimm.2021.11.021","article-title":"Passive immunization with anti-chimeric protein PilQ\/PilA -DSL region IgY does not protect against mortality associated with Pseudomonas aeruginosa sepsis in a rabbit model","volume":"141","author":"Zamani","year":"2022","journal-title":"Mol Immunol"},{"key":"2026050905020285700_ref67","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1016\/j.vaccine.2015.07.031","article-title":"OmpW is a potential target for eliciting protective immunity against Acinetobacter baumannii infections","volume":"33","author":"Huang","year":"2015","journal-title":"Vaccine"},{"key":"2026050905020285700_ref68","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.tim.2017.01.005","article-title":"The secrets of Acinetobacter secretion","volume":"25","author":"Weber","year":"2017","journal-title":"Trends Microbiol"},{"key":"2026050905020285700_ref69","doi-asserted-by":"publisher","first-page":"105291","DOI":"10.1016\/j.micpath.2021.105291","article-title":"Anti-Omp34 antibodies protect against Acinetobacter baumannii in a murine sepsis model","volume":"161","author":"Naghipour Erami","year":"2021","journal-title":"Microb Pathog"},{"key":"2026050905020285700_ref70","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3904\/kjim.2018.159","article-title":"Vibrio vulnificus infection: a persistent threat to public health","volume":"33","author":"Yun","year":"2018","journal-title":"Korean J Intern Med"},{"key":"2026050905020285700_ref71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/6678513","article-title":"Protective effects of chicken egg yolk immunoglobulins (IgYs) against Vibrio vulnificus infections","volume":"2021","author":"Cai","year":"2021","journal-title":"J Immunol Res"},{"key":"2026050905020285700_ref72","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3389\/fmicb.2019.00539","article-title":"Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review","volume":"10","author":"Mulani","year":"2019","journal-title":"Front Microbiol"},{"key":"2026050905020285700_ref73","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/1040841X.2019.1599813","article-title":"Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria","volume":"45","author":"Liu","year":"2019","journal-title":"Crit Rev Microbiol"},{"key":"2026050905020285700_ref74","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1089\/fpd.2008.0258","article-title":"Adhesion and growth inhibitory effect of chicken egg yolk antibody (IgY) on Salmonella enterica serovars enteritidis and Typhimurium in vitro","volume":"6","author":"Chalghoumi","year":"2009","journal-title":"Foodborne Pathog Dis"},{"key":"2026050905020285700_ref75","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.psj.2019.11.019","article-title":"The effect of capsulated and noncapsulated egg-yolk\u2013specific antibody to reduce colonization in the intestine of Salmonella enterica ssp. enterica serovar Infantis\u2013challenged broiler chickens","volume":"99","author":"Hatamzade Isfahani","year":"2020","journal-title":"Poult Sci"},{"key":"2026050905020285700_ref76","doi-asserted-by":"publisher","first-page":"239","DOI":"10.18502\/ajmb.v15i4.13497","article-title":"Production of egg yolk antibody (IgY) against Vibrio cholerae O1: protective effect in mice","volume":"15","author":"Shoushtari","year":"2023","journal-title":"Avicenna J Med Biotechnol"},{"key":"2026050905020285700_ref77","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/21645515.2018.1514224","article-title":"IgY antibodies for the immunoprophylaxis and therapy of respiratory infections","volume":"15","author":"Abbas","year":"2019","journal-title":"Hum Vaccin Immunother"},{"key":"2026050905020285700_ref78","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5455\/JMID.2024.v14.i3.2","article-title":"Chicken immunoglobulin (IgY) as an alternative treatment for bacterial infections, emphasizing advantages, disadvantages and mechanisms","volume":"14","author":"Esmaeili","year":"2024","journal-title":"J Microbiol Infecti Dis"},{"key":"2026050905020285700_ref79","doi-asserted-by":"publisher","first-page":"1065353","DOI":"10.3389\/fimmu.2023.1065353","article-title":"IgY antibodies: the promising potential to overcome antibiotic resistance","volume":"14","author":"El-Kafrawy","year":"2023","journal-title":"Front Immunol"},{"key":"2026050905020285700_ref80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2022.05.010","article-title":"Synergistic activity between beta-lactams and igy antibodies against Pseudomonas aeruginosa in vitro","volume":"148","author":"Sanches","year":"2022","journal-title":"Mol Immunol"},{"key":"2026050905020285700_ref81","volume-title":"Investigation of antibody-based immune recognition of infections with Salmonella enterica serovars Typhimurium and Enteritidis","author":"Naqid","year":"2016"},{"key":"2026050905020285700_ref82","doi-asserted-by":"publisher","first-page":"1049917","DOI":"10.3389\/fmicb.2023.1049917","article-title":"Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: are vaccines and adjuvants effective strategies?","volume":"14","author":"Hu","year":"2023","journal-title":"Front Microbiol"},{"key":"2026050905020285700_ref83","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3233\/THC-181255","article-title":"Egg yolk immunoglobulins' impact on experimental periodontitis caused by Porphyromonas gingivalis","volume":"26","author":"Wang","year":"2018","journal-title":"Technol Health Care"},{"key":"2026050905020285700_ref84","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/clinids\/19.3.500","article-title":"Antibody-dependent enhancement of infection and the pathogenesis of viral disease","volume":"19","author":"Morens","year":"1994","journal-title":"Clin Infect Dis"},{"key":"2026050905020285700_ref85","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/v11030301","article-title":"Zika virus-specific IgY results are therapeutic following a lethal Zika virus challenge without inducing antibody-dependent enhancement","volume":"11","author":"O\u2019Donnell","year":"2019","journal-title":"Viruses"},{"key":"2026050905020285700_ref86","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.ijbiomac.2021.08.078","article-title":"Exploring the potential usefulness of IgY for antiviral therapy: A current review","volume":"189","author":"Silva","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"2026050905020285700_ref87","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/s41587-023-01676-0","article-title":"High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq","volume":"41","author":"Liu","year":"2023","journal-title":"Nat Biotechnol"},{"key":"2026050905020285700_ref88","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.28.605493","article-title":"Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping","author":"Fan","year":"2024","journal-title":"bioRxiv"}],"container-title":["Antibody Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/abt\/advance-article-pdf\/doi\/10.1093\/abt\/tbaf007\/62352076\/tbaf007.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/abt\/article-pdf\/8\/2\/111\/62352076\/tbaf007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/abt\/article-pdf\/8\/2\/111\/62352076\/tbaf007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:02:10Z","timestamp":1778317330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/abt\/article\/8\/2\/111\/8064717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,9]]},"references-count":88,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/abt\/tbaf007","relation":{},"ISSN":["2516-4236"],"issn-type":[{"value":"2516-4236","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,9]]}}}