{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:55:35Z","timestamp":1790186135311,"version":"4.1.0"},"reference-count":137,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":452,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1093\/advances\/nmaa073","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T15:09:47Z","timestamp":1590592187000},"page":"1583-1602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-6595","authenticated-orcid":false,"given":"Maria G","family":"Grammatikopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-1995","authenticated-orcid":false,"given":"Dimitrios G","family":"Goulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-8494","authenticated-orcid":false,"given":"Konstantinos","family":"Gkiouras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9810-7583","authenticated-orcid":false,"given":"Xenophon","family":"Theodoridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi K","family":"Gkouskou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Evangeliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimis","family":"Dardiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-7902","authenticated-orcid":false,"given":"Dimitrios P","family":"Bogdanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/advances\/nmaa073_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/brainsci8080148","article-title":"The expanding role of ketogenic diets in adult neurological disorders","volume":"8","author":"McDonald","year":"2018","journal-title":"Brain Sci"},{"key":"10.1093\/advances\/nmaa073_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jalz.2016.03.001","article-title":"2016 Alzheimer's disease facts and figures","volume":"12","author":"Alzheimer's Association","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.1093\/advances\/nmaa073_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1093\/advances\/nmaa073_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.trci.2019.02.005","article-title":"The Alzheimer's Prevention Initiative Generation Program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease","volume":"5","author":"Lopez\u00a0Lopez","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1093\/advances\/nmaa073_bib6","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1093\/advances\/nmaa073_bib7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3233\/JAD-170248","article-title":"Relationships of dietary patterns, foods, and micro- and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review","volume":"59","author":"Solfrizzi","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1093\/advances\/nmaa073_bib8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/aje\/kwx330","article-title":"Fish intake, genetic predisposition to Alzheimer disease, and decline in global cognition and memory in 5 cohorts of older persons","volume":"187","author":"Samieri","year":"2018","journal-title":"Am J Epidemiol"},{"key":"10.1093\/advances\/nmaa073_bib9","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/WNL.0000000000002719","article-title":"APOE \u03b54 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline","volume":"86","author":"van\u00a0de\u00a0Rest","year":"2016","journal-title":"Neurology"},{"key":"10.1093\/advances\/nmaa073_bib10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jama.2015.19451","article-title":"Association of seafood consumption, brain mercury level, and APOE \u03b5 4 status with brain neuropathology in older adults","volume":"315","author":"Morris","year":"2016","journal-title":"JAMA"},{"key":"10.1093\/advances\/nmaa073_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodres.2018.10.090","article-title":"Japanese, Mediterranean and Argentinean diets and their potential roles in neurodegenerative diseases","volume":"120","author":"Dohrmann","year":"2019","journal-title":"Food Res Int"},{"key":"10.1093\/advances\/nmaa073_bib12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer\u2019s disease\u2014a review","volume":"10","author":"van\u00a0den\u00a0Brink","year":"2019","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmaa073_bib13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","article-title":"MIND diet associated with reduced incidence of Alzheimer's disease","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jalz.2018.12.011","article-title":"MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study","volume":"15","author":"Hosking","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neurobiolaging.2018.12.008","article-title":"Diet and biomarkers of Alzheimer's disease: a systematic review and meta-analysis","volume":"76","author":"Hill","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1093\/advances\/nmaa073_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jalz.2019.09.001","article-title":"Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias","volume":"16","author":"Antonell","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.12999","article-title":"Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease","volume":"1367","author":"Cunnane","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1093\/advances\/nmaa073_bib19","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3233\/JAD-141074","article-title":"Lower brain 18f-fluorodeoxyglucose uptake but normal 11c-acetoacetate metabolism in mild Alzheimer's disease dementia","volume":"43","author":"Castellano","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1093\/advances\/nmaa073_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuint.2017.05.019","article-title":"Neuroketotherapeutics: a modern review of a century-old therapy","volume":"117","author":"Koppel","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1093\/advances\/nmaa073_bib21","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3945\/ajcn.117.162263","article-title":"A high-glycemic diet is associated with cerebral amyloid burden in cognitively normal older adults","volume":"106","author":"Taylor","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmaa073_bib22","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1096\/fj.201600773R","article-title":"Novel ketone diet enhances physical and cognitive performance","volume":"30","author":"Murray","year":"2016","journal-title":"FASEB J"},{"key":"10.1093\/advances\/nmaa073_bib23","doi-asserted-by":"crossref","first-page":"25950","DOI":"10.1074\/jbc.M110.138198","article-title":"A ketone ester diet increases brain malonyl-CoA and uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar rat","volume":"285","author":"Kashiwaya","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1093\/advances\/nmaa073_bib24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3389\/fnagi.2018.00391","article-title":"A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus","volume":"10","author":"Hernandez","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"10.1093\/advances\/nmaa073_bib25","first-page":"P128","article-title":"Strategies to increase brain energy supply in mild Alzheimer's disease","volume":"13","author":"Castellano","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib26","doi-asserted-by":"crossref","first-page":"P883","DOI":"10.1016\/j.jalz.2017.07.275","article-title":"The KU Alzheimer's disease ketogenic diet feasibility and retention trial: results from a pilot study","volume":"13","author":"Swerdlow","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib27","doi-asserted-by":"crossref","first-page":"P883","DOI":"10.1016\/j.jalz.2017.07.276","article-title":"Pharmacokinetics and dynamics of a ketogenic intervention in Alzheimer's disease and frontotemporal dementia","volume":"13","author":"Nygaard","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.dadm.2019.01.009","article-title":"APOE \u03b54, the door to insulin-resistant dyslipidemia and brain fog? A case study","volume":"11","author":"Stoykovich","year":"2019","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1093\/advances\/nmaa073_bib29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.dsx.2019.01.035","article-title":"Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: a case study","volume":"13","author":"Morrill","year":"2019","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"key":"10.1093\/advances\/nmaa073_bib30","article-title":"Ketogenic diet for the treatment and prevention of dementia: a review","author":"Davis","year":"2020","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.1093\/advances\/nmaa073_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/JNC.0000000000000110","article-title":"Cognitive effects of a ketogenic diet on neurocognitive impairment in adults aging with HIV: a pilot study","volume":"31","author":"Morrison","year":"2020","journal-title":"J Assoc Nurses AIDS Care"},{"key":"10.1093\/advances\/nmaa073_bib32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5720\/kjcn.2019.24.6.525","article-title":"Effects of low-carbohydrate and high-fat diet supplemented with ketogenic drink on cognitive function and physical performance in the elderly at high risk for dementia","volume":"24","author":"Kim","year":"2019","journal-title":"Korean J Community Nutr"},{"key":"10.1093\/advances\/nmaa073_bib33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab"},{"key":"10.1093\/advances\/nmaa073_bib34","unstructured":">34 Dhillon KK, Gupta S,. Biochemistry, ketogenesis. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2020. Available from: https:\/\/www.ncbi.nim.nih.gov\/books\/NBK493179,."},{"issue":"16","key":"10.1093\/advances\/nmaa073_bib35","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.3390\/ijms20163892","article-title":"Ketogenic diet in Alzheimer's disease","volume":"20","author":"Rusek","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1093\/advances\/nmaa073_bib36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.nut.2018.10.003","article-title":"The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease","volume":"60","author":"Broom","year":"2019","journal-title":"Nutrition"},{"key":"10.1093\/advances\/nmaa073_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jalz.2014.01.006","article-title":"A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's","volume":"11","author":"Newport","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib38","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3945\/an.117.015388","article-title":"Perspective: neuroregenerative nutrition","volume":"8","author":"Steindler","year":"2017","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmaa073_bib39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WCO.0000000000000432","article-title":"New insights into the mechanisms of the ketogenic diet","volume":"30","author":"Boison","year":"2017","journal-title":"Curr Opin Neurol"},{"key":"10.1093\/advances\/nmaa073_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yapd.2010.08.003","article-title":"Ketosis and the ketogenic diet, 2010: advances in treating epilepsy and other disorders","volume":"57","author":"Freeman","year":"2010","journal-title":"Adv Pediatr"},{"key":"10.1093\/advances\/nmaa073_bib41","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/advances\/nmy129","article-title":"Epigenetic regulation of metabolism and inflammation by calorie restriction","volume":"10","author":"Hern\u00e1ndez-Saavedra","year":"2019","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmaa073_bib42","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1093\/advances\/nmaa073_bib43","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1093\/advances\/nmaa073_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"10.1093\/advances\/nmaa073_bib45","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3233\/JAD-180995","article-title":"Preliminary report on the feasibility and efficacy of the modified Atkins diet for treatment of mild cognitive impairment and early Alzheimer's disease","volume":"68","author":"Brandt","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"7S","key":"10.1093\/advances\/nmaa073_bib46","first-page":"P342","article-title":"O4\u201005\u201003: ketogenic diet effects on brain ketone metabolism and Alzheimer\u2019s disease Csf biomarkers","volume":"12","author":"Craft","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"5","key":"10.1093\/advances\/nmaa073_bib47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jalz.2018.12.017","article-title":"A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment","volume":"15","author":"Fortier","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-7075-6-31","article-title":"Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"6","author":"Henderson","year":"2009","journal-title":"Nutr Metab (Lond)"},{"key":"10.1093\/advances\/nmaa073_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-2350-12-137","article-title":"Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study","volume":"12","author":"Henderson","year":"2011","journal-title":"BMC Med Genet"},{"key":"10.1093\/advances\/nmaa073_bib50","doi-asserted-by":"crossref","first-page":"425.e19","DOI":"10.1016\/j.neurobiolaging.2010.10.006","article-title":"Dietary ketosis enhances memory in mild cognitive impairment","volume":"33","author":"Krikorian","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1093\/advances\/nmaa073_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbacli.2015.01.001","article-title":"Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: a randomized controlled trial","volume":"3","author":"Rebello","year":"2015","journal-title":"BBA Clin"},{"key":"10.1093\/advances\/nmaa073_bib53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0197-4580(03)00087-3","article-title":"Effects of \u03b2-hydroxybutyrate on cognition in memory-impaired adults","volume":"25","author":"Reger","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exger.2018.07.009","article-title":"Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: results of a randomized, double-blinded, pilot study","volume":"111","author":"Torosyan","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1093\/advances\/nmaa073_bib55","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ebiom.2019.08.032","article-title":"Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment","volume":"47","author":"Nagpal","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1093\/advances\/nmaa073_bib56","doi-asserted-by":"crossref","first-page":"P581","DOI":"10.1016\/j.jalz.2019.06.1248","article-title":"Changes in adiposity and CSF biomarkers following a modified Mediterranean diet","volume":"15","author":"Brinkley","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib57","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jand.2018.05.019","article-title":"Evaluation of the Healthy Eating Index-2015","volume":"118","author":"Reedy","year":"2018","journal-title":"J Acad Nutr Diet"},{"key":"10.1093\/advances\/nmaa073_bib58","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.1093\/advances\/nmaa073_bib59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state.\u201d A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1093\/advances\/nmaa073_bib60","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1093\/advances\/nmaa073_bib61","series-title":"Hopkins Verbal Learning Test \u2013 Revised. Administration manual","author":"Brandt","year":"2001"},{"key":"10.1093\/advances\/nmaa073_bib62","series-title":"Brief Visuospatial Memory Test-revised professional manual 1997","author":"Benedict","year":"1997"},{"key":"10.1093\/advances\/nmaa073_bib63","first-page":"219","article-title":"Independence of verbal and spatial paired associate learning","volume":"32","author":"Krikorian","year":"1996","journal-title":"Brain Cogn"},{"key":"10.1093\/advances\/nmaa073_bib64","unstructured":">64 Van\u00a0der\u00a0Linden M, Coyette F, Jgremem P,. L'\u00e9preuve de Rappel Libre\/Rappel Indic\u00e9 \u00e0 16 items (RL\/RI-16). In: Van\u00a0der\u00a0Linden M, Agniel AE, editors. L'\u00e9valuation des troubles de la m\u00e9moire: pr\u00e9sentation de quatre tests de m\u00e9moire \u00e9pisodique (avec leur \u00e9talonnage). Marseille, France: Solal; 2004. p. 25\u201347."},{"key":"10.1093\/advances\/nmaa073_bib65","series-title":"The Boston Naming Test 1983","author":"Kaplan","year":"1983"},{"key":"10.1093\/advances\/nmaa073_bib66","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J Exp Psychol"},{"key":"10.1093\/advances\/nmaa073_bib67","unstructured":">67 Delis D, Kaplan E, Kramer J,. Delis-Kaplan Executive Function System\u00ae (D-KEFS\u00ae): examiner\u2019s manual: flexibility of thinking, concept formation, problem solving, planning, creativity, impulse control, inhibition. The Psychological Corporation, editor. San Antonio, TX: Pearson; 2001."},{"key":"10.1093\/advances\/nmaa073_bib68","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"Validity of the Trail Making Test as an indicator of organic brain damage","volume":"8","author":"Reitan","year":"1958","journal-title":"Percept Mot Skills"},{"key":"10.1093\/advances\/nmaa073_bib69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J Intern Med"},{"key":"10.1093\/advances\/nmaa073_bib70","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1093\/advances\/nmaa073_bib71","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib72","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1093\/advances\/nmaa073_bib73","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"10.1093\/advances\/nmaa073_bib74","unstructured":">74 Lorr M, McNair DM, Heuchert JW,. Profile of Mood States: Bi-polar Form. North Tonawanda, NY: Multi-Health Systems (MHS); 2003. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK493179\/,."},{"key":"10.1093\/advances\/nmaa073_bib75","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/00005650-200012000-00005","article-title":"Minimum data set for home care: a valid instrument to assess frail older people living in the community","volume":"38","author":"Landi","year":"2000","journal-title":"Med Care"},{"key":"10.1093\/advances\/nmaa073_bib76","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1097\/01.wad.0000213878.47924.44","article-title":"ADCS Prevention Instrument Project: ADCS-Clinicians' Global Impression of Change Scales (ADCS-CGIC), Self-rated and Study Partner-rated Versions","volume":"20","author":"Schneider","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1093\/advances\/nmaa073_bib77","doi-asserted-by":"crossref","unstructured":">77 Wechsler D,. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio, TX: Psychological Corporation; 1997.","DOI":"10.1037\/t49755-000"},{"key":"10.1093\/advances\/nmaa073_bib78","series-title":"Wechsler Memory Scale-Revised","author":"Wechsler","year":"1987"},{"key":"10.1093\/advances\/nmaa073_bib79","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1515\/cclm.2002.197","article-title":"Taqman systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E","volume":"40","author":"Koch","year":"2002","journal-title":"Clin Chem Lab Med"},{"key":"10.1093\/advances\/nmaa073_bib80","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/ana.410360614","article-title":"Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studies","volume":"36","author":"Nalbantoglu","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1093\/advances\/nmaa073_bib81","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","article-title":"Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders","volume":"17","author":"Augustin","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1093\/advances\/nmaa073_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0007114515001452","article-title":"The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action","volume":"114","author":"Fernando","year":"2015","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmaa073_bib83","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fneur.2019.00585","article-title":"Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms","volume":"10","author":"Yang","year":"2019","journal-title":"Front Neurol"},{"key":"10.1093\/advances\/nmaa073_bib84","first-page":"264","article-title":"Ketogenic dietary therapies for epilepsy and beyond","volume":"22","author":"deCampo","year":"2019","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1093\/advances\/nmaa073_bib85","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.3390\/ijms20112797","article-title":"Mediterranean and MIND diets containing olive biophenols reduces the prevalence of Alzheimer's disease","volume":"20","author":"Omar","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1093\/advances\/nmaa073_bib86","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/JAD-131436","article-title":"Coconut oil attenuates the effects of amyloid-\u03b2 on cortical neurons in vitro","volume":"39","author":"Nafar","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1093\/advances\/nmaa073_bib87","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10545-016-9930-4","article-title":"The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome","volume":"39","author":"Kanabus","year":"2016","journal-title":"J Inherit Metab Dis"},{"key":"10.1093\/advances\/nmaa073_bib88","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuint.2017.01.008","article-title":"Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways","volume":"105","author":"Nafar","year":"2017","journal-title":"Neurochem Int"},{"key":"10.1093\/advances\/nmaa073_bib89","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3233\/JAD-180202","article-title":"Ketogenic medium chain triglycerides increase brain energy metabolism in Alzheimer's disease","volume":"64","author":"Croteau","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1093\/advances\/nmaa073_bib90","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/ajcn\/nqz073","article-title":"Three consecutive weeks of nutritional ketosis has no effect on cognitive function, sleep, and mood compared with a high-carbohydrate, low-fat diet in healthy individuals: a randomized, crossover, controlled trial","volume":"110","author":"Iacovides","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmaa073_bib91","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/jn\/nxz308","article-title":"The ketogenic diet: evidence for optimism but high-quality research needed","volume":"150","author":"Ludwig","year":"2020","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmaa073_bib92","doi-asserted-by":"crossref","first-page":"e000354","DOI":"10.1136\/bmjdrc-2016-000354","article-title":"Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes","volume":"5","author":"Snorgaard","year":"2017","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1093\/advances\/nmaa073_bib93","unstructured":">93 Masood W, Uppaluri KR,. Ketogenic diet. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2019. Available from: https:\/\/www.ncbi.nim.nih.gov\/books\/NBK499830,."},{"key":"10.1093\/advances\/nmaa073_bib94","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","article-title":"The role of metabolic disorders in Alzheimer disease and vascular dementia","volume":"66","author":"Craft","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1093\/advances\/nmaa073_bib95","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archneurol.2010.225","article-title":"Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes","volume":"68","author":"Baker","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1093\/advances\/nmaa073_bib96","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.nutres.2018.11.007","article-title":"Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults","volume":"62","author":"Mohorko","year":"2019","journal-title":"Nutr Res"},{"key":"10.1093\/advances\/nmaa073_bib97","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0404.1981.tb00788.x","article-title":"Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids","volume":"63","author":"Lying-Tunell","year":"2009","journal-title":"Acta Neurol Scand"},{"key":"10.1093\/advances\/nmaa073_bib98","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-121867","article-title":"Comparing brain amyloid deposition, glucose metabolism, and atrophy in mild cognitive impairment with and without a family history of dementia","volume":"35","author":"Mosconi","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.1093\/advances\/nmaa073_bib99","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/archneur.62.11.1728","article-title":"Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease","volume":"62","author":"Anchisi","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1093\/advances\/nmaa073_bib100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13195-019-0512-1","article-title":"FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study","volume":"11","author":"Ou","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.1093\/advances\/nmaa073_bib101","doi-asserted-by":"crossref","first-page":"17490","DOI":"10.1038\/s41598-017-17718-y","article-title":"Blood-brain glucose transfer in Alzheimer's disease: effect of GLP-1 analog treatment","volume":"7","author":"Gejl","year":"2017","journal-title":"Sci Rep"},{"key":"10.1093\/advances\/nmaa073_bib102","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40265-016-0674-0","article-title":"Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for Alzheimer's disease","volume":"77","author":"de\u00a0la\u00a0Monte","year":"2017","journal-title":"Drugs"},{"key":"10.1093\/advances\/nmaa073_bib103","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fnmol.2016.00053","article-title":"Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of Alzheimer's disease","volume":"9","author":"Cunnane","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"10.1093\/advances\/nmaa073_bib104","unstructured":"\">104 Cahill GF Jr, Veech RL,. Ketoacids? Good medicine?. Trans Am Clin Climatol Assoc. 2003;114:149\u201361.; discussion 162\u20133."},{"key":"10.1093\/advances\/nmaa073_bib105","doi-asserted-by":"crossref","first-page":"D409","DOI":"10.1051\/ocl\/2018020","article-title":"Ketones, omega-3 fatty acids and the Yin-Yang balance in the brain: insights from infant development and Alzheimer's disease, and implications for human brain evolution","volume":"25","author":"Cunnane","year":"2018","journal-title":"OCL"},{"key":"10.1093\/advances\/nmaa073_bib106","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat Genet"},{"key":"10.1093\/advances\/nmaa073_bib107","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41598-018-36820-3","article-title":"Polygenic impact of common genetic risk loci for Alzheimer's disease on cerebral blood flow in young individuals","volume":"9","author":"Chandler","year":"2019","journal-title":"Sci Rep"},{"key":"10.1093\/advances\/nmaa073_bib108","doi-asserted-by":"crossref","first-page":"e201900303","DOI":"10.26508\/lsa.201900303","article-title":"Rate of brain aging and APOE \u03b54 are synergistic risk factors for Alzheimer\u2019s disease","volume":"2","author":"Glorioso","year":"2019","journal-title":"Life Sci Alliance"},{"key":"10.1093\/advances\/nmaa073_bib109","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.pmbts.2019.06.013","article-title":"Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease","volume":"168","author":"Westfall","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1093\/advances\/nmaa073_bib110","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s13311-014-0295-9","article-title":"Genetics of Alzheimer's disease","volume":"11","author":"Guerreiro","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1093\/advances\/nmaa073_bib111","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s10072-019-03976-3","article-title":"Dietary pattern in relation to the risk of Alzheimer's disease: a systematic review","volume":"40","author":"Samadi","year":"2019","journal-title":"Neurol Sci"},{"issue":"12","key":"10.1093\/advances\/nmaa073_bib112","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.jalz.2019.05.011","article-title":"Genetic resilience to Alzheimer\u2019s disease in APOE \u03b54 homozygotes: a systematic review","volume":"15","author":"Huq","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib113","first-page":"P1106","article-title":"Diet-related alterations in white matter microstructure in participants at risk for AD","volume":"15","author":"Kellar","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib114","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s12031-019-01363-3","article-title":"Does SCFD1 rs10139154 polymorphism decrease Alzheimer's disease risk?","volume":"69","author":"Stamati","year":"2019","journal-title":"J Mol Neurosci"},{"key":"10.1093\/advances\/nmaa073_bib115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jalz.2018.10.003","article-title":"Subjective cognitive decline and rates of incident Alzheimer\u2019s disease and non\u2013Alzheimer\u2019s disease dementia","volume":"15","author":"Slot","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib116","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.neurobiolaging.2003.12.023","article-title":"ApoE genotype accounts for the vast majority of AD risk and AD pathology","volume":"25","author":"Raber","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib117","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuron.2014.08.005","article-title":"More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration","volume":"83","author":"Lane-Donovan","year":"2014","journal-title":"Neuron"},{"key":"10.1093\/advances\/nmaa073_bib118","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuron.2017.09.003","article-title":"Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes","volume":"96","author":"Zhao","year":"2017","journal-title":"Neuron"},{"key":"10.1093\/advances\/nmaa073_bib119","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.R800009200","article-title":"Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure","volume":"284","author":"Zhong","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1093\/advances\/nmaa073_bib120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","article-title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","volume":"15","author":"Yamazaki","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1093\/advances\/nmaa073_bib121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers","volume":"51","author":"Lee","year":"2019","journal-title":"Exp Mol Med"},{"key":"10.1093\/advances\/nmaa073_bib122","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/ana.410360616","article-title":"Amyloid \u03b2 protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer\u2019s disease","volume":"36","author":"Nakamura","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1093\/advances\/nmaa073_bib123","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nutres.2007.06.010","article-title":"Low economic status is associated with suboptimal intakes of nutritious foods by adults in the National Health and Nutrition Examination Survey 1999-2002","volume":"27","author":"Bowman","year":"2007","journal-title":"Nutr Res"},{"key":"10.1093\/advances\/nmaa073_bib124","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neurobiolaging.2005.07.003","article-title":"Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment","volume":"27","author":"de\u00a0Leon","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410440108","article-title":"Longitudinal study of cerebrospinal fluid levels of tau, A\u03b21-40, and A\u03b21-42(43) in Alzheimer\u2019s disease: a study in Japan","volume":"44","author":"Kanai","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1093\/advances\/nmaa073_bib126","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00702-004-0235-7","article-title":"Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease","volume":"112","author":"Mollenhauer","year":"2005","journal-title":"J Neural Transm"},{"key":"10.1093\/advances\/nmaa073_bib127","doi-asserted-by":"crossref","first-page":"a006221","DOI":"10.1101\/cshperspect.a006221","article-title":"Fluid biomarkers in Alzheimer disease","volume":"2","author":"Blennow","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1093\/advances\/nmaa073_bib128","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jalz.2011.05.2351","article-title":"Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2019.09.075","article-title":"The path forward in Alzheimer's disease therapeutics: reevaluating the amyloid cascade hypothesis","author":"Tolar","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1093\/advances\/nmaa073_bib130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2019.09.015","article-title":"Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study","volume":"86","author":"Neth","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.1093\/advances\/nmaa073_bib131","series-title":"Your guide to lowering cholesterol with therapeutic lifestyle changes (TLC)","author":"NIH,\u00a0National\u00a0Heart,\u00a0Lung\u00a0and\u00a0Blood\u00a0Institute","year":"2005"},{"issue":"2","key":"10.1093\/advances\/nmaa073_bib132","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/advances\/nmz104","article-title":"Utility of ketone supplementation to enhance physical performance: a systematic review","volume":"11","author":"Margolis","year":"2020","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmaa073_bib133","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pediatrneurol.2017.01.007","article-title":"Complications during ketogenic diet initiation: prevalence, treatment, and influence on seizure outcomes","volume":"68","author":"Lin","year":"2017","journal-title":"Pediatr Neurol"},{"key":"10.1093\/advances\/nmaa073_bib134","doi-asserted-by":"crossref","first-page":"nzz003","DOI":"10.1093\/cdn\/nzz003","article-title":"An experimental ketogenic diet for Alzheimer disease was nutritionally dense and rich in vegetables and avocado","volume":"3","author":"Taylor","year":"2019","journal-title":"Curr Dev Nutr"},{"key":"10.1093\/advances\/nmaa073_bib135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/nu11010169","article-title":"Role of ketogenic diets in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease)","volume":"11","author":"W\u0142odarek","year":"2019","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmaa073_bib136","series-title":"Neurological concepts in Ancient Greek medicine","author":"Walshe","year":"2016"},{"key":"10.1093\/advances\/nmaa073_bib137","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00008877-200609000-00009","article-title":"Neuroprotective and disease-modifying effects of the ketogenic diet","volume":"17","author":"Gasior","year":"2006","journal-title":"Behav Pharmacol"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322003507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322003507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/advances\/article-pdf\/11\/6\/1583\/34302346\/nmaa073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/advances\/article-pdf\/11\/6\/1583\/34302346\/nmaa073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:58:17Z","timestamp":1761872297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831322003507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":137,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2161831322003507"],"URL":"https:\/\/doi.org\/10.1093\/advances\/nmaa073","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/advances\/nmaa073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by ELSEVIERCOMPANY on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}]}}