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Morphology and significance of the human yolk sac. In: Barnea ER, Hustin J, Jauniaux E, editors. The first twelve weeks of gestation. Berlin: Springer-Verlag; 1992.pp. 192\u2013213.","DOI":"10.1007\/978-3-642-84385-3_11"},{"key":"10.1093\/advances\/nmaa100_bib77","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.placenta.2013.08.003","article-title":"Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation","volume":"34","author":"Burke","year":"2013","journal-title":"Placenta"},{"key":"10.1093\/advances\/nmaa100_bib78","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/bdra.20537","article-title":"Regulation of folate receptor 1 gene expression in the visceral endoderm","volume":"85","author":"Salbaum","year":"2009","journal-title":"Birth Defect Res A Clin Mol Teratol"},{"key":"10.1093\/advances\/nmaa100_bib79","doi-asserted-by":"crossref","first-page":"58.e1-6","DOI":"10.1016\/j.ajog.2007.02.009","article-title":"Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal 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Teratol"},{"key":"10.1093\/advances\/nmaa100_bib82","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/tera.1420410405","article-title":"Experimental manipulation of the rodent visceral yolk sac","volume":"41","author":"Beckman","year":"1990","journal-title":"Teratology"},{"key":"10.1093\/advances\/nmaa100_bib83","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2337\/diab.39.5.575","article-title":"Uptake of myo-inositol by early somite rat conceptus: transport kinetics and effects of hyperglycemia","volume":"39","author":"Weigensberg","year":"1990","journal-title":"Diabetes"},{"key":"10.1093\/advances\/nmaa100_bib84","doi-asserted-by":"crossref","first-page":"237.e1-9","DOI":"10.1016\/j.ajog.2008.06.028","article-title":"Diabetes mellitus and birth defects","volume":"199","author":"Correa","year":"2008","journal-title":"Am J Obstet 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Eurocat, European network of population-based, registries for the epidemiological surveillance of congenital anomalies, [Internet]. [Accessed 2019 Sep 13].Available from: http:\/\/www.eurocat-network.eu\/,."},{"key":"10.1093\/advances\/nmaa100_bib103","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-90-481-9485-8_20","article-title":"The prevalence of congenital anomalies in Europe","volume":"686","author":"Dolk","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmaa100_bib104","first-page":"S16","article-title":"EUROCAT Project Management Committee; EUROCAT Working Group. Paper 2: EUROCAT public health indicators for congenital anomalies in Europe","volume":"91","author":"Khoshnood","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1093\/advances\/nmaa100_bib105","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1471-0528.2008.01700.x","article-title":"EUROCAT Working Group. 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