{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:43:41Z","timestamp":1792219421647,"version":"4.4.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1093\/advances\/nmac082","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:22:46Z","timestamp":1661329366000},"page":"2445-2457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-7029","authenticated-orcid":false,"given":"Rima","family":"Obeid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Derbyshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Sch\u00f6n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/advances\/nmac082_bib1","series-title":"Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline","author":"Institute of Medicine","year":"1998"},{"key":"10.1093\/advances\/nmac082_bib2","first-page":"4484","article-title":"Dietary reference values for choline","volume":"14","author":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2016","journal-title":"EFSA J"},{"issue":"12","key":"10.1093\/advances\/nmac082_bib3","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1017\/S0007114515003700","article-title":"Dietary intake and food sources of choline in European populations","volume":"114","author":"Vennemann","year":"2015","journal-title":"Br J Nutr"},{"issue":"10","key":"10.1093\/advances\/nmac082_bib4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3390\/nu10101513","article-title":"Dietary choline intake: current state of knowledge across the life cycle","volume":"10","author":"Wiedeman","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib5","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/ajcn\/82.4.836","article-title":"Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery","volume":"82","author":"Molloy","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jnutbio.2005.01.011","article-title":"Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk","volume":"16","author":"Ilcol","year":"2005","journal-title":"J Nutr Biochem"},{"key":"10.1093\/advances\/nmac082_bib7","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/jn\/125.12.3049","article-title":"Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver","volume":"125","author":"Zeisel","year":"1995","journal-title":"J Nutr"},{"issue":"5378","key":"10.1093\/advances\/nmac082_bib8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.281.5378.794","article-title":"Choline, a vital amine","volume":"281","author":"Blusztajn","year":"1998","journal-title":"Science"},{"key":"10.1093\/advances\/nmac082_bib9","unstructured":"Patterson, K, Bhagwat, S, Williams, JR, Howe, JC, Holden, JM, Zeisel, SH, et al., USDA Database for the Choline Content of Common Foods, release 2. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service USDA. 2008. Available from: , https:\/\/data.nal.usda.gov\/dataset\/usda-database-choline-content-common-foods-release-2-2008, (accessed 24 April 2021)."},{"issue":"5","key":"10.1093\/advances\/nmac082_bib10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/jn\/133.5.1302","article-title":"Concentrations of choline-containing compounds and betaine in common foods","volume":"133","author":"Zeisel","year":"2003","journal-title":"J Nutr"},{"issue":"11","key":"10.1093\/advances\/nmac082_bib11","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/jn\/124.11.2197","article-title":"Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver","volume":"124","author":"Kim","year":"1994","journal-title":"J Nutr"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.conb.2006.09.002","article-title":"The role of acetylcholine in learning and memory","volume":"16","author":"Hasselmo","year":"2006","journal-title":"Curr Opin Neurobiol"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0024-3205(75)90194-0","article-title":"Brain acetylcholine: increase after systemic choline administration","volume":"16","author":"Cohen","year":"1975","journal-title":"Life Sci"},{"issue":"5605","key":"10.1093\/advances\/nmac082_bib14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/266848a0","article-title":"Effects of dietary choline on nicotinic acetylcholine receptors in brain","volume":"266","author":"Morley","year":"1977","journal-title":"Nature"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1096\/fj.01-0564fje","article-title":"Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro","volume":"16","author":"Fisher","year":"2002","journal-title":"FASEB J"},{"issue":"2","key":"10.1093\/advances\/nmac082_bib16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/tera.1053","article-title":"Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos","volume":"64","author":"Fisher","year":"2001","journal-title":"Teratology"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/ajmg.a.35372","article-title":"Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure","volume":"158A","author":"Rogers","year":"2012","journal-title":"Am J Med Genet A"},{"issue":"1","key":"10.1093\/advances\/nmac082_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biopsych.2020.02.007","article-title":"Development of brain networks in utero: relevance for common neural disorders","volume":"88","author":"Thomason","year":"2020","journal-title":"Biol Psychiatry"},{"issue":"13","key":"10.1093\/advances\/nmac082_bib19","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1097\/00001756-199709080-00005","article-title":"Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory","volume":"8","author":"Meck","year":"1997","journal-title":"Neuroreport"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib20","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1037\/0735-7044.103.6.1234","article-title":"Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both","volume":"103","author":"Meck","year":"1989","journal-title":"Behav Neurosci"},{"issue":"1","key":"10.1093\/advances\/nmac082_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T","article-title":"Effects of prenatal alcohol exposure on the hippocampus: spatial behavior, electrophysiology, and neuroanatomy","volume":"10","author":"Berman","year":"2000","journal-title":"Hippocampus"},{"issue":"10","key":"10.1093\/advances\/nmac082_bib22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/bdra.20713","article-title":"Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats","volume":"88","author":"Thomas","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib23","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hipo.22009","article-title":"The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt","volume":"22","author":"Monk","year":"2012","journal-title":"Hippocampus"},{"issue":"3","key":"10.1093\/advances\/nmac082_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/hipo.20925","article-title":"Choline supplementation mitigates trace, but not delay, eyeblink conditioning deficits in rats exposed to alcohol during development","volume":"22","author":"Thomas","year":"2012","journal-title":"Hippocampus"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib25","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3390\/nu12061731","article-title":"Choline, neurological development and brain function: a systematic review focusing on the first 1000 days","volume":"12","author":"Derbyshire","year":"2020","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmac082_bib26","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/acer.14040","article-title":"Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure","volume":"43","author":"Mattson","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib27","doi-asserted-by":"crossref","first-page":"e010247","DOI":"10.1136\/bmjopen-2015-010247","article-title":"Plea for routinely presenting prediction intervals in meta-analysis","volume":"6","author":"IntHout","year":"2016","journal-title":"BMJ Open"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1176\/appi.ajp.2018.17070836","article-title":"Prenatal primary prevention of mental illness by micronutrient supplements in pregnancy","volume":"175","author":"Freedman","year":"2018","journal-title":"Am J Psychiatry"},{"issue":"9","key":"10.1093\/advances\/nmac082_bib29","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/acer.13817","article-title":"Effect of choline supplementation on neurological, cognitive, and behavioral outcomes in offspring arising from alcohol exposure during development: a quantitative systematic review of clinical and preclinical studies","volume":"42","author":"Akison","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib30","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/nutrit\/nuv010","article-title":"Effects of choline on health across the life course: a systematic review","volume":"73","author":"Leermakers","year":"2015","journal-title":"Nutr Rev"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib31","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/19390211.2019.1639875","article-title":"Choline: the neurocognitive essential nutrient of interest to obstetricians and gynecologists","volume":"17","author":"Wallace","year":"2020","journal-title":"J Diet Suppl"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/bdra.23236","article-title":"Dietary intake of choline and neural tube defects in Mexican Americans","volume":"100","author":"Lavery","year":"2014","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"2","key":"10.1093\/advances\/nmac082_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/aje\/kwh187","article-title":"Periconceptional dietary intake of choline and betaine and neural tube defects in offspring","volume":"160","author":"Shaw","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/bdra.20675","article-title":"Periconceptional nutrient intakes and risks of neural tube defects in California","volume":"88","author":"Carmichael","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/aje\/kwz040","article-title":"One-carbon cofactor intake and risk of neural tube defects among women who meet folic acid recommendations: a multicenter case-control study","volume":"188","author":"Petersen","year":"2019","journal-title":"Am J Epidemiol"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/EDE.0b013e3181ac9fe7","article-title":"Choline and risk of neural tube defects in a folate-fortified population","volume":"20","author":"Shaw","year":"2009","journal-title":"Epidemiology"},{"issue":"2","key":"10.1093\/advances\/nmac082_bib37","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/pr4009805","article-title":"Metabonomic profiling of human placentas reveals different metabolic patterns among subtypes of neural tube defects","volume":"13","author":"Chi","year":"2014","journal-title":"J Proteome Res"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib38","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3945\/ajcn.113.079319","article-title":"Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects","volume":"100","author":"Mills","year":"2014","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib39","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1096\/fj.201700692RR","article-title":"Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study","volume":"32","author":"Caudill","year":"2018","journal-title":"FASEB J"},{"issue":"3","key":"10.1093\/advances\/nmac082_bib40","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1176\/appi.ajp.2012.12070940","article-title":"Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk","volume":"170","author":"Ross","year":"2013","journal-title":"Am J Psychiatry"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/appi.ajp.2015.15091188","article-title":"Perinatal phosphatidylcholine supplementation and early childhood behavior problems: evidence for CHRNA7 moderation","volume":"173","author":"Ross","year":"2016","journal-title":"Am J Psychiatry"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib42","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3945\/ajcn.112.037184","article-title":"Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial","volume":"96","author":"Cheatham","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib43","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/acer.13769","article-title":"Efficacy of maternal choline supplementation during pregnancy in mitigating adverse effects of prenatal alcohol exposure on growth and cognitive function: a randomized, double-blind, placebo-controlled clinical trial","volume":"42","author":"Jacobson","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.alcohol.2015.08.005","article-title":"The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants","volume":"49","author":"Kable","year":"2015","journal-title":"Alcohol"},{"issue":"12","key":"10.1093\/advances\/nmac082_bib45","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1007\/s10995-015-1779-x","article-title":"Dose and timing of prenatal alcohol exposure and maternal nutritional supplements: developmental effects on 6-month-old infants","volume":"19","author":"Coles","year":"2015","journal-title":"Matern Child Health J"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib46","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3945\/ajcn.114.099168","article-title":"Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial","volume":"102","author":"Wozniak","year":"2015","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1093\/advances\/nmac082_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s11689-020-09312-7","article-title":"Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder","volume":"12","author":"Wozniak","year":"2020","journal-title":"J Neurodev Disord"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib48","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3945\/ajcn.116.142075","article-title":"Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders","volume":"104","author":"Nguyen","year":"2016","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib49","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ajcn\/87.4.896","article-title":"Choline concentrations in human maternal and cord blood and intelligence at 5 y of age","volume":"87","author":"Signore","year":"2008","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib50","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-3016.2012.01264.x","article-title":"Maternal intake of methyl-donor nutrients and child cognition at 3 years of age","volume":"26","author":"Villamor","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"12","key":"10.1093\/advances\/nmac082_bib51","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/aje\/kws395","article-title":"Choline intake during pregnancy and child cognition at age 7 years","volume":"177","author":"Boeke","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1093\/advances\/nmac082_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2020.05.019","article-title":"Maternal choline and respiratory coronavirus effects on fetal brain development","volume":"128","author":"Freedman","year":"2020","journal-title":"J Psychiatr Res"},{"key":"10.1093\/advances\/nmac082_bib53","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jpeds.2018.12.010","article-title":"Higher gestational choline levels in maternal infection are protective for infant brain development","volume":"208","author":"Freedman","year":"2019","journal-title":"J Pediatr"},{"issue":"10","key":"10.1093\/advances\/nmac082_bib54","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1017\/S003329171900179X","article-title":"Interaction of maternal choline levels and prenatal marijuana's effects on the offspring","volume":"50","author":"Hoffman","year":"2020","journal-title":"Psychol Med"},{"key":"10.1093\/advances\/nmac082_bib55","first-page":"1","article-title":"Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age","author":"Hunter","year":"2021","journal-title":"Psychol Med"},{"issue":"3","key":"10.1093\/advances\/nmac082_bib56","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1017\/S0033291719003313","article-title":"Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development","volume":"51","author":"Hunter","year":"2021","journal-title":"Psychol Med"},{"issue":"4","key":"10.1093\/advances\/nmac082_bib57","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/schbul\/sbaa171","article-title":"Black American maternal prenatal choline, offspring gestational age at birth, and developmental predisposition to mental illness","volume":"47","author":"Hunter","year":"2021","journal-title":"Schizophr Bull"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib58","doi-asserted-by":"crossref","first-page":"e43448","DOI":"10.1371\/journal.pone.0043448","article-title":"Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1093\/advances\/nmac082_bib59","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.3390\/nu7115452","article-title":"Synergistic effects of human milk nutrients in the support of infant recognition memory: an observational study","volume":"7","author":"Cheatham","year":"2015","journal-title":"Nutrients"},{"issue":"3","key":"10.1093\/advances\/nmac082_bib60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/nu10030381","article-title":"Concentrations of water-soluble forms of choline in human milk from lactating women in Canada and Cambodia","volume":"10","author":"Wiedeman","year":"2018","journal-title":"Nutrients"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib61","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/jn\/nxy108","article-title":"Plasma betaine is positively associated with developmental outcomes in healthy toddlers at age 2 years who are not meeting the recommended Adequate Intake for dietary choline","volume":"148","author":"Wiedeman","year":"2018","journal-title":"J Nutr"},{"issue":"2","key":"10.1093\/advances\/nmac082_bib62","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1017\/S0007114512005077","article-title":"Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study","volume":"110","author":"Strain","year":"2013","journal-title":"Br J Nutr"},{"issue":"11","key":"10.1093\/advances\/nmac082_bib63","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.3390\/nu11112758","article-title":"Natural choline from egg yolk phospholipids is more efficiently absorbed compared with choline bitartrate; outcomes of a randomized trial in healthy adults","volume":"11","author":"Smolders","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1093\/advances\/nmac082_bib64","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/ajcn\/66.3.622","article-title":"Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction","volume":"66","author":"Savendahl","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib65","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fasebj.5.7.2010061","article-title":"Choline, an essential nutrient for humans","volume":"5","author":"Zeisel","year":"1991","journal-title":"FASEB J"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib66","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1017\/S000711451100674X","article-title":"Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women","volume":"108","author":"Wallace","year":"2012","journal-title":"Br J Nutr"},{"issue":"8","key":"10.1093\/advances\/nmac082_bib67","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/07315724.2018.1466213","article-title":"Effects of egg consumption and choline supplementation on plasma choline and trimethylamine-N-oxide in a young population","volume":"37","author":"Lemos","year":"2018","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib68","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3945\/ajcn.111.022772","article-title":"Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans","volume":"95","author":"Yan","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1093\/advances\/nmac082_bib69","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/acer.13768","article-title":"Feasibility and acceptability of maternal choline supplementation in heavy drinking pregnant women: a randomized, double-blind, placebo-controlled clinical trial","volume":"42","author":"Jacobson","year":"2018","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1093\/advances\/nmac082_bib70","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jnutbio.2007.12.002","article-title":"Choline status is not a reliable indicator of moderate changes in dietary choline consumption in premenopausal women","volume":"20","author":"Abratte","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1093\/advances\/nmac082_bib71","doi-asserted-by":"crossref","unstructured":"Wurtman, RJ, Cansev, M, Ulus, IH. Choline and its products acetylcholine and phosphatidylcholine. In: Lajtha A, Tettamanti G, Goracci G (eds), Handbook of Neurochemistry and Molecular Neurobiology. Boston, MA: Springer; 2009. p. 443\u2013501.","DOI":"10.1007\/978-0-387-30378-9_18"},{"issue":"10","key":"10.1093\/advances\/nmac082_bib72","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1096\/fj.07-8227com","article-title":"Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes","volume":"21","author":"Resseguie","year":"2007","journal-title":"FASEB J"},{"issue":"6","key":"10.1093\/advances\/nmac082_bib73","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s00216-012-6602-6","article-title":"High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS\/MS","volume":"405","author":"Midttun","year":"2013","journal-title":"Anal Bioanal Chem"},{"issue":"5","key":"10.1093\/advances\/nmac082_bib74","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neubiorev.2005.12.003","article-title":"An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring","volume":"30","author":"McCann","year":"2006","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831323000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831323000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/advances\/advance-article-pdf\/doi\/10.1093\/advances\/nmac082\/46339810\/nmac082.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/advances\/advance-article-pdf\/doi\/10.1093\/advances\/nmac082\/46339810\/nmac082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:15:31Z","timestamp":1761873331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831323000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S2161831323000868"],"URL":"https:\/\/doi.org\/10.1093\/advances\/nmac082","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/advances\/nmac082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}