{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T07:37:01Z","timestamp":1777189021168,"version":"3.51.4"},"reference-count":86,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022244","name":"National Institute for Health Research Applied Research Collaboration West","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1093\/advances\/nmac088","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:22:43Z","timestamp":1661329363000},"page":"2488-2519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Adverse Effects of Excessive Zinc Intake in Infants and Children Aged 0\u20133 Years: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-5366","authenticated-orcid":false,"given":"Marena","family":"Ceballos-Rasgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-2768","authenticated-orcid":false,"given":"Nicola M","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonette","family":"Mallard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria H","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Montez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Xipsiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/advances\/nmac088_bib1","unstructured":"World Health Organization\/Food and Agriculture Organization of the United Nations. Vitamin and mineral requirements in human nutrition, 2nd ed, [Internet]. Geneva, Siwtzerland:, World Health Organization; 2004 [cited August 30, 2022]. Available from: http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/42716\/9241546123.pdf;jsessionid=A16E0CB2D96C7034FF573A649CC46D7B?sequence=1"},{"key":"10.1093\/advances\/nmac088_bib2","series-title":"Application of risk analysis to food standards issues","author":"FAO\/WHO (Food and Agricultural Organization of the UN\/World Health Organization) Expert Consultation","year":"1995"},{"key":"10.1093\/advances\/nmac088_bib3","unstructured":"European Food Safety Authority (EFSA). Tolerable upper intake level on vitamins and minerals. [Internet]. 2006; [cited August 30, 2022]. Available from: https:\/\/www.efsa.europa.eu\/sites\/default\/files\/efsa_rep\/blobserver_assets\/ndatolerableuil.pdf."},{"issue":"5S Suppl","key":"10.1093\/advances\/nmac088_bib4","doi-asserted-by":"crossref","first-page":"1360S","DOI":"10.1093\/jn\/130.5.1360S","article-title":"Zinc homeostasis in humans","volume":"130","author":"King","year":"2000","journal-title":"J Nutr"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ajcn\/51.2.225","article-title":"Zinc toxicity","volume":"51","author":"Fosmire","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmac088_bib6","series-title":"Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","author":"Institute of Medicine (US) Panel on Micronutrients","year":"2001"},{"issue":"1 Suppl 2","key":"10.1093\/advances\/nmac088_bib7","first-page":"S94","article-title":"Assessment of the risk of zinc deficiency in populations and options for its control","volume":"25","author":"Brown","year":"2004","journal-title":"Food Nutr Bull"},{"issue":"10","key":"10.1093\/advances\/nmac088_bib8","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/ajcn\/29.10.1114","article-title":"Growth of infants fed a zinc supplemented formula","volume":"29","author":"Walravens","year":"1976","journal-title":"Am J Clin Nutr"},{"key":"#cr-split#-10.1093\/advances\/nmac088_bib9.1","unstructured":"World Health Organization\/Food and Agriculture Organization of the United Nations. FAO\/WHO nutrient requirements for children aged 0-36 months. [Internet]. 2020"},{"key":"#cr-split#-10.1093\/advances\/nmac088_bib9.2","unstructured":"[cited August 30, 2022]. Available from: https:\/\/www.who.int\/groups\/fao-who-nutrient-requirements-for-children-aged-0-36-months"},{"key":"10.1093\/advances\/nmac088_bib10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ejcn.2017.138","article-title":"Zinc and multivitamin supplementation have contrasting effects on infant iron status: a randomized, double-blind, placebo-controlled clinical trial","volume":"72","author":"Carter","year":"2018","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib13","doi-asserted-by":"crossref","first-page":"e61486","DOI":"10.1371\/journal.pone.0061486","article-title":"Effectiveness of zinc supplementation to full term normal infants: a community based double blind, randomized, controlled, clinical trial","volume":"8","author":"Radhakrishna","year":"2013","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmac088_bib14","series-title":"Breast milk intake and content in calcium, vitamin D and zinc","author":"Rios-Leyvraz","year":"2021"},{"key":"10.1093\/advances\/nmac088_bib15","unstructured":"Higgins, JPT, Thomas, J, Chandler, J, Cumpston, M, Li, T, Page, MJ, et al., editors. Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). [Internet]. Cochrane; 2022; [cited August 30, 2022]. Available from: www.training.cochrane.org\/handbook"},{"key":"10.1093\/advances\/nmac088_bib16","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"12","key":"10.1093\/advances\/nmac088_bib17","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/ajcn\/32.12.2532","article-title":"Zinc nutritional status of young middle-income children and effects of consuming zinc-fortified breakfast cereals","volume":"32","author":"Hambidge","year":"1979","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1079\/BJN19930026","article-title":"A trial of zinc supplementation in young rural Gambian children","volume":"69","author":"Bates","year":"1993","journal-title":"Br J Nutr"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib19","article-title":"Anthropometric and biochemical nutritional status, parasitic infestation, social stratification. The effects of zinc supplementation in children of Venezuelan public kindergartens","volume":"22","author":"Mendoza","year":"2016","journal-title":"Rev Esp Nutr Comunitaria"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archpedi.1992.02160180069019","article-title":"Zinc-induced copper deficiency in an infant","volume":"146","author":"Botash","year":"1992","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"9","key":"10.1093\/advances\/nmac088_bib21","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1651-2227.2005.tb02097.x","article-title":"Chronic zinc toxicity in an infant who received zinc therapy for atopic dermatitis","volume":"94","author":"Sugiura","year":"2005","journal-title":"Acta Paediatr"},{"key":"10.1093\/advances\/nmac088_bib22","unstructured":"Joanna Briggs Institute. Critical appraisal tools. [Internet]. 2020; [cited March 5, 2021]. Available from: https:\/\/jbi.global\/critical-appraisal-tools."},{"issue":"4","key":"10.1093\/advances\/nmac088_bib23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jclinepi.2010.09.011","article-title":"GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1093\/advances\/nmac088_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jclinepi.2018.01.012","article-title":"GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence","volume":"111","author":"Sch\u00fcnemann","year":"2019","journal-title":"J Clin Epidemiol"},{"key":"10.1093\/advances\/nmac088_bib25","unstructured":"Ryan, R, Hill, S. How to GRADE the quality of the evidence. [Internet]. Cochrane Consumers and Communication Group; 2016; [cited September 07, 2022]. Available from: https:\/\/opal.latrobe.edu.au\/articles\/journal_contribution\/How_to_GRADE\/6818894"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib26","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/ajcn\/80.5.1276","article-title":"Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia","volume":"80","author":"Alarcon","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.mpg.0000189340.00516.30","article-title":"Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications","volume":"42","author":"Awasthi","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"10.1093\/advances\/nmac088_bib28","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/jn\/135.9.2187","article-title":"Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants","volume":"135","author":"Baqui","year":"2005","journal-title":"J Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/sj.ejcn.1602336","article-title":"Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants","volume":"60","author":"Berger","year":"2006","journal-title":"Eur J Clin Nutr"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib30","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1542\/peds.109.6.e86","article-title":"Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young North Indian children","volume":"109","author":"Bhandari","year":"2002","journal-title":"Pediatrics"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/jn\/137.1.112","article-title":"Adding zinc to supplemental iron and folic acid does not affect mortality and severe morbidity in young children","volume":"137","author":"Bhandari","year":"2007","journal-title":"J Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib32","first-page":"1","article-title":"Isani Z. Diarrhea in Pakistan","volume":"103","author":"Bhutta","year":"1999","journal-title":"Pediatrics"},{"issue":"9490","key":"10.1093\/advances\/nmac088_bib33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(05)67109-7","article-title":"Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial","volume":"366","author":"Brooks","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/ajcn\/85.2.538","article-title":"Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and plasma zinc concentrations of young Peruvian children","volume":"85","author":"Brown","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"11-12","key":"10.1093\/advances\/nmac088_bib35","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.nut.2013.05.023","article-title":"Mineral status of non-anemic Peruvian infants taking an iron and copper syrup with or without zinc from 6 to 18 months of age: a randomized controlled trial","volume":"29","author":"Caulfield","year":"2013","journal-title":"Nutrition"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ejcn.2009.127","article-title":"Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery","volume":"64","author":"Chang","year":"2010","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib37","first-page":"3","article-title":"Effects of vitamin A, vitamin A plus zinc, and multiple micronutrients on anemia in preschool children in Chongqing, China","volume":"21","author":"Chen","year":"2012","journal-title":"Asia Pac J Clin Nutr"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-10-145","article-title":"Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6\u201324 months","volume":"10","author":"Chhagan","year":"2010","journal-title":"BMC Public Health"},{"issue":"11","key":"10.1093\/advances\/nmac088_bib39","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/jn\/131.11.2860","article-title":"Effects of iron and zinc supplementation in Indonesian infants on micronutrient status and growth","volume":"131","author":"Dijkhuizen","year":"2001","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmac088_bib40","first-page":"301","article-title":"Linear growth of stunted infants with low haemoglobin","volume":"16","author":"Fahmida","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"issue":"11-12","key":"10.1093\/advances\/nmac088_bib41","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.nut.2015.05.024","article-title":"Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial","volume":"31","author":"Fallah","year":"2015","journal-title":"Nutrition"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1651-2227.2003.tb02501.x","article-title":"Impact of zinc supplementation on diarrhoeal morbidity in rural children of West Bengal, India","volume":"92","author":"Gupta","year":"2003","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib43","doi-asserted-by":"crossref","first-page":"e0122242","DOI":"10.1371\/journal.pone.0122242","article-title":"Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young Burkinabe children: a cluster-randomized trial","volume":"10","author":"Hess","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1093\/advances\/nmac088_bib44","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/08035250600603024","article-title":"The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children","volume":"95","author":"Kurug\u00f6l","year":"2006","journal-title":"Acta Paediatr"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib45","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1442-200X.2007.02448.x","article-title":"Effect of zinc sulfate on common cold in children: randomized, double blind study","volume":"49","author":"Kurug\u00f6l","year":"2007","journal-title":"Pediatr Int"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib46","first-page":"311","article-title":"Initiation of zinc treatment for acute childhood diarrhoea and risk for vomiting or regurgitation: a randomized, double-blind, placebo-controlled trial","volume":"23","author":"Larson","year":"2005","journal-title":"J Health Popul Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib47","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/ajcn\/77.4.883","article-title":"A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc","volume":"77","author":"Lind","year":"2003","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib48","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/ajcn\/81.3.637","article-title":"Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc","volume":"81","author":"L\u00f3pez De Roma\u00f1a","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"10.1093\/advances\/nmac088_bib49","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s13312-014-0503-z","article-title":"Zinc supplementation for prevention of acute respiratory infections in infants: a randomized controlled trial","volume":"51","author":"Malik","year":"2014","journal-title":"Indian Pediatr"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib50","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.aller.2015.12.006","article-title":"Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: a 12-month randomised controlled trial","volume":"44","author":"Martinez-Estevez","year":"2016","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib51","first-page":"220","article-title":"Comparison of iron alone and zinc plus iron supplementation effect on the clinical and laboratory features of children with iron deficiency anemia","volume":"13","author":"Moradveisi","year":"2019","journal-title":"Int J Hematol Stem Cell Res"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib52","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/ajcn\/71.3.789","article-title":"Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers","volume":"71","author":"Mu\u00f1oz","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"10.1093\/advances\/nmac088_bib53","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/jn\/136.9.2427","article-title":"Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old","volume":"136","author":"Olney","year":"2006","journal-title":"J Nutr"},{"issue":"10","key":"10.1093\/advances\/nmac088_bib54","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1365-3156.2008.02138.x","article-title":"Effect of iron or multiple micronutrient supplements on the prevalence of anaemia among anaemic young children of a malaria-endemic area: a randomized double-blind trial","volume":"13","author":"Ou\u00e9draogo","year":"2008","journal-title":"Trop Med Int Health"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2891-12-131","article-title":"Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana","volume":"12","author":"Owusu-Agyei","year":"2013","journal-title":"Nutr J"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib56","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/MEG.0000000000000320","article-title":"Acceptability and efficacy of a gel hypotonic oral rehydration solution in children with acute gastroenteritis","volume":"27","author":"Passariello","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"7308","key":"10.1093\/advances\/nmac088_bib57","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/bmj.323.7308.314","article-title":"Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial","volume":"323","author":"Rahman","year":"2001","journal-title":"BMJ"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib58","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.2006.75.1.0750126","article-title":"Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon","volume":"75","author":"Richard","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajcn\/65.1.13","article-title":"Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers","volume":"65","author":"Rosado","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"10.1093\/advances\/nmac088_bib60","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.cgh.2014.01.024","article-title":"Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial","volume":"12","author":"Ryan","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib61","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jped.2012.11.004","article-title":"Zinc and other micronutrients supplementation through the use of sprinkles: impact on the occurrence of diarrhea and respiratory infections in institutionalized children","volume":"89","author":"Sampaio","year":"2013","journal-title":"J Pediatr (Rio J)"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib62","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1651-2227.2004.tb18254.x","article-title":"Zinc supplementation for four months does not affect plasma copper concentration in infants","volume":"93","author":"Sazawal","year":"2004","journal-title":"Acta Paediatr"},{"issue":"9505","key":"10.1093\/advances\/nmac088_bib63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(06)67962-2","article-title":"Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in","volume":"367","author":"Sazawal","year":"2006","journal-title":"Lancet"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib64","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4269\/ajtmh.2000.62.663","article-title":"The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea","volume":"62","author":"Shankar","year":"2000","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib65","first-page":"227","article-title":"Effects of zinc supplementation on 1- to 5-year old children","volume":"82","author":"Silva","year":"2006","journal-title":"J Pediatr (Rio J)"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/07315724.1999.10718854","article-title":"Vitamin A and zinc supplementation of preschool children","volume":"18","author":"Smith","year":"1999","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"10.1093\/advances\/nmac088_bib67","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1542\/peds.109.5.898","article-title":"Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children","volume":"109","author":"Strand","year":"2002","journal-title":"Pediatrics"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib68","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jtemb.2014.07.009","article-title":"Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and zinc status of Indonesian pre-school children","volume":"28","author":"Surono","year":"2014","journal-title":"J Trace Elem Med Biol"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib69","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3945\/ajcn.2009.28907","article-title":"A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal","volume":"91","author":"Valentiner-Branth","year":"2010","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10.1093\/advances\/nmac088_bib70","doi-asserted-by":"crossref","first-page":"e1001125","DOI":"10.1371\/journal.pmed.1001125","article-title":"Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial","volume":"8","author":"Veenemans","year":"2011","journal-title":"PLoS Med"},{"issue":"9","key":"10.1093\/advances\/nmac088_bib71","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/136.9.2405","article-title":"Iron and zinc supplementation improved iron and zinc status, but not physical growth, of apparently healthy, breast-fed infants in rural communities of northeast Thailand","volume":"136","author":"Wasantwisut","year":"2006","journal-title":"J Nutr"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib72","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ajcn\/87.3.723","article-title":"Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiency","volume":"87","author":"Wuehler","year":"2008","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1093\/advances\/nmac088_bib73","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/jn\/133.4.1075","article-title":"Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children","volume":"133","author":"Zlotkin","year":"2003","journal-title":"J Nutr"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-016-0765-9","volume":"17","author":"Abbeddou","year":"2017","journal-title":"BMC Pediatr"},{"issue":"11","key":"10.1093\/advances\/nmac088_bib75","doi-asserted-by":"crossref","first-page":"e02581","DOI":"10.1016\/j.heliyon.2019.e02581","article-title":"Zinc supplementation is an effective and feasible strategy to prevent growth retardation in 6 to 24 month children: a pragmatic double blind, randomized trial","volume":"5","author":"Abdollahi","year":"2019","journal-title":"Heliyon"},{"issue":"24","key":"10.1093\/advances\/nmac088_bib76","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1001\/jama.279.24.1962","article-title":"Zinc gluconate lozenges for treating the common cold in children","volume":"279","author":"Macknin","year":"1998","journal-title":"JAMA"},{"key":"10.1093\/advances\/nmac088_bib77","series-title":"Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","author":"Institute of Medicine","year":"2001"},{"issue":"1","key":"10.1093\/advances\/nmac088_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-021-02620-6","article-title":"The reference intervals of whole blood copper, zinc, calcium, magnesium, and iron in infants under 1 year old","volume":"200","author":"Ha","year":"2022","journal-title":"Biol Trace Elem Res"},{"issue":"5\u20136","key":"10.1093\/advances\/nmac088_bib79","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cca.2011.12.005","article-title":"Pediatric reference intervals for serum copper and zinc","volume":"413","author":"Lin","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1093\/advances\/nmac088_bib80","unstructured":"Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Model for the development of tolerable upper intake levels. In: Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride [Internet]. Washington (DC): National Academies Press; 1997. p. 51\u201370."},{"issue":"8","key":"10.1093\/advances\/nmac088_bib81","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3390\/nu11081885","article-title":"Iron and zinc homeostasis and interactions: does enteric zinc excretion cross-talk with intestinal iron absorption?","volume":"11","author":"Kondaiah","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/08880018.2015.1138007","article-title":"Reference values of serum transferrin receptor (sTfR) and sTfR\/log ferritin index in healthy children","volume":"33","author":"V\u00e1zquez-L\u00f3pez","year":"2016","journal-title":"Pediatr Hematol Oncol"},{"issue":"3","key":"10.1093\/advances\/nmac088_bib83","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/ijlh.13391","article-title":"Soluble transferrin receptor during infancy and reference intervals for the Roche Cobas platform","volume":"43","author":"Larsson","year":"2021","journal-title":"Int J Lab Hematol"},{"issue":"2","key":"10.1093\/advances\/nmac088_bib84","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12519-009-0024-3","article-title":"Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index","volume":"5","author":"Ooi","year":"2009","journal-title":"World J Pediatr"},{"issue":"6","key":"10.1093\/advances\/nmac088_bib85","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2036.2008.03787.x","article-title":"Meta-analysis: zinc supplementation for acute gastroenteritis in children","volume":"28","author":"Patro","year":"2008","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831323000881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831323000881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/advances\/advance-article-pdf\/doi\/10.1093\/advances\/nmac088\/46683641\/nmac088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/advances\/advance-article-pdf\/doi\/10.1093\/advances\/nmac088\/46683641\/nmac088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:23:25Z","timestamp":1761873805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831323000881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S2161831323000881"],"URL":"https:\/\/doi.org\/10.1093\/advances\/nmac088","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse Effects of Excessive Zinc Intake in Infants and Children Aged 0\u20133 Years: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/advances\/nmac088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}