{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:55:52Z","timestamp":1792634152275,"version":"4.5.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:00:00Z","timestamp":1533945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1093\/advances\/nmy036","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T01:53:24Z","timestamp":1530928404000},"page":"625-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Use of Stable Isotopes to Evaluate Bioefficacy of Provitamin A Carotenoids, Vitamin A Status, and Bioavailability of Iron and Zinc"],"prefix":"10.1016","volume":"9","author":[{"given":"Jesse","family":"Sheftel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Loechl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat","family":"Mokhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry A","family":"Tanumihardjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/advances\/nmy036_bib1","series-title":"Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition","year":"2013"},{"key":"10.1093\/advances\/nmy036_bib2","series-title":"Africa's food and nutrition security situation: where are we and how did we get here?","author":"Benson","year":"2004"},{"key":"10.1093\/advances\/nmy036_bib3","series-title":"Guidelines on food fortification with micronutrients","first-page":"1","article-title":"The role of food fortification in the control of micronutrient malnutrition","year":"2006"},{"key":"10.1093\/advances\/nmy036_bib4","first-page":"329","article-title":"Biofortification of staple crops: an emerging strategy to combat hidden hunger","volume":"7","author":"Tanumihardjo","year":"2008","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10.1093\/advances\/nmy036_bib5","first-page":"373","article-title":"Food-based approaches for ensuring adequate vitamin A nutrition","volume":"7","author":"Tanumihardjo","year":"2008","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"10.1093\/advances\/nmy036_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/156482650702800307","article-title":"Estimating the global costs of vitamin A capsule supplementation: a review of the literature","volume":"28","author":"Neidecker-Gonzales","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1024\/0300-9831\/a000042","article-title":"Provitamin A carotenoid bioavailability: what really matters?","volume":"80","author":"Tanumihardjo","year":"2010","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib8","series-title":"Encyclopedia of human nutrition.","first-page":"149","article-title":"Bioavailability","author":"Davidsson","year":"2013"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1024\/0300-9831\/a000182","article-title":"Usefulness of vitamin A isotope methods for status assessment: from deficiency through excess","volume":"84","author":"Tanumihardjo","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib10","doi-asserted-by":"crossref","first-page":"1816S","DOI":"10.3945\/jn.115.229708","article-title":"Biomarkers of Nutrition for Development (BOND)\u2014vitamin A review","volume":"146","author":"Tanumihardjo","year":"2016","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1079\/PHN2004715","article-title":"Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans","volume":"8","author":"Furr","year":"2005","journal-title":"Public Health Nutr"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib12","doi-asserted-by":"crossref","first-page":"1468S","DOI":"10.3945\/ajcn.2010.28674G","article-title":"Bioconversion of dietary provitamin A carotenoids to vitamin A in humans","volume":"91","author":"Tang","year":"2010","journal-title":"Am J Clin Nutr"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib13","doi-asserted-by":"crossref","first-page":"691S","DOI":"10.3945\/ajcn.110.005819","article-title":"New frontiers in science and technology: nuclear techniques in nutrition","volume":"94","author":"Davidsson","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1515\/pac-2015-0503","article-title":"Isotopic compositions of the elements 2013 (IUPAC technical report)","volume":"88","author":"Meija","year":"2016","journal-title":"Pure Appl Chem"},{"key":"10.1093\/advances\/nmy036_bib15","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.3945\/jn.110.125500","article-title":"Accelerator mass spectrometry can be used to assess vitamin A metabolism quantitatively in boys in a community setting","volume":"140","author":"Aklamati","year":"2010","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib16","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3945\/jn.109.105114","article-title":"A minute dose of 14C-\u03b2-carotene is absorbed and converted to retinoids in humans","volume":"139","author":"Ho","year":"2009","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib17","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/S0022-2275(20)31972-6","article-title":"Long-term kinetic study of \u03b2-carotene, using accelerator mass spectrometry in an adult volunteer","volume":"41","author":"Dueker","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1093\/advances\/nmy036_bib18","first-page":"99","article-title":"Method for the assessment of vitamin A liver stores","volume":"31","author":"Bausch","year":"1977","journal-title":"Acta Vitaminol Enzymol"},{"key":"10.1093\/advances\/nmy036_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1740-8709.2011.00293.x","article-title":"Breastfeeding practices of Cameroonian mothers determined by dietary recall since birth and the dose-to-the-mother deuterium-oxide turnover technique","volume":"8","author":"Medoua","year":"2012","journal-title":"Matern Child Nutr"},{"key":"10.1093\/advances\/nmy036_bib20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/nu9020169","article-title":"\u201cDose-to-mother\u201d deuterium oxide dilution technique: an accurate strategy to measure vitamin A intake in breastfed infants","volume":"9","author":"Lopez-Teros","year":"2017","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmy036_bib21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1740-8709.2012.00421.x","article-title":"Breast milk zinc transfer and early post-natal growth among urban South Indian term infants using measures of breast milk volume and breast milk zinc concentrations","volume":"10","author":"Samuel","year":"2014","journal-title":"Matern Child Nutr"},{"key":"10.1093\/advances\/nmy036_bib22","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.3390\/nu7064271","article-title":"The potential for zinc stable isotope techniques and modelling to determine optimal zinc supplementation","volume":"7","author":"Tran","year":"2015","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmy036_bib23","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0021-9258(19)45460-4","article-title":"Regulation of retinol-binding protein metabolism by vitamin A status in the rat","volume":"247","author":"Muto","year":"1972","journal-title":"J Biol Chem"},{"key":"10.1093\/advances\/nmy036_bib24","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/ajcn\/84.6.1344","article-title":"Evaluation of vitamin A supplementation regimens in Ghanaian postpartum mothers with the use of the modified-relative-dose-response test","volume":"84","author":"Tchum","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib25","first-page":"1294","article-title":"Evaluation of a green leafy vegetable intervention in Ghanaian postpartum mothers","volume":"9","author":"Tchum","year":"2009","journal-title":"Afr J Food Agric Nutr Dev"},{"key":"10.1093\/advances\/nmy036_bib26","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3945\/jn.112.166454","article-title":"High prevalence of vitamin A deficiency is detected by the modified relative dose-response test in six-month-old Senegalese breast-fed infants","volume":"142","author":"Agne-Djigo","year":"2012","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13690-016-0121-4","article-title":"Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods","volume":"74","author":"Newton","year":"2016","journal-title":"Arch Public Health"},{"key":"10.1093\/advances\/nmy036_bib28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.proche.2015.03.054","article-title":"Vitamin A fortification efforts require accurate monitoring of population vitamin A status to prevent excessive intakes","volume":"14","author":"Tanumihardjo","year":"2015","journal-title":"Procedia Chem"},{"key":"10.1093\/advances\/nmy036_bib29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3945\/jn.114.208132","article-title":"Comparisons among equations used for retinol isotope dilution in the assessment of total body stores and total liver reserves","volume":"145","author":"Gannon","year":"2015","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib30","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/jn\/130.11.2844","article-title":"Vitamin A status assessment in rats with 13C4-retinyl acetate and gas chromatography\/combustion\/isotope ratio mass spectrometry","volume":"130","author":"Tanumihardjo","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3945\/jn.113.182998","article-title":"Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children","volume":"144","author":"Pinkaew","year":"2014","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib32","series-title":"Report: priorities in the assessment of vitamin A and iron status in populations, Panama City, Panama, 15\u201317 September 2010","first-page":"63","article-title":"Influence of infection and inflammation on biomarkers of nutritional status with an emphasis on vitamin A and iron","author":"Thurnham","year":"2012"},{"key":"10.1093\/advances\/nmy036_bib33","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3945\/ajcn.115.113050","article-title":"Serum retinol concentrations demonstrate high specificity after correcting for inflammation but questionable sensitivity compared with liver stores calculated from isotope dilution in determining vitamin A deficiency in Thai and Zambian children","volume":"102","author":"Suri","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1079\/BJN19720094","article-title":"Absorption of labelled vitamin A in children during infection","volume":"27","author":"Sivakumar","year":"1972","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmy036_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.nutr.21.1.167","article-title":"Vitamin A, infection, and immune function","volume":"21","author":"Stephensen","year":"2001","journal-title":"Annu Rev Nutr"},{"key":"10.1093\/advances\/nmy036_bib36","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1194\/jlr.M600528-JLR200","article-title":"Model-based compartmental analysis indicates a reduced mobilization of hepatic vitamin A during inflammation in rats","volume":"48","author":"Gieng","year":"2007","journal-title":"J Lipid Res"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1024\/0300-9831\/a000184","article-title":"International experiences in assessing vitamin A status and applying the vitamin A-labeled isotope dilution method","volume":"84","author":"Lopez-Teros","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1024\/0300-9831\/a000186","article-title":"Existing and emerging technologies for measuring stable isotope labelled retinol in biological samples: isotope dilution analysis of body retinol stores","volume":"84","author":"Preston","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib39","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3945\/ajcn.111.030775","article-title":"\u03b2-Carotene in Golden Rice is as good as \u03b2-carotene in oil at providing vitamin A to children","volume":"96","author":"Tang","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1194\/jlr.D040204","article-title":"An LC\/MS\/MS method for stable isotope dilution studies of \u03b2-carotene bioavailability, bioconversion, and vitamin A status in humans","volume":"55","author":"Oxley","year":"2013","journal-title":"J Lipid Res"},{"key":"10.1093\/advances\/nmy036_bib41","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3945\/jn.112.164830","article-title":"Daily consumption of orange-fleshed sweet potato for 60 days increased plasma \u03b2-carotene concentration but did not increase total body vitamin A pool size in Bangladeshi women","volume":"142","author":"Jamil","year":"2012","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib42","series-title":"Handbook on vitamin A tracer dilution methods to assess status and evaluate intervention programs","author":"Haskell","year":"2005"},{"key":"10.1093\/advances\/nmy036_bib43","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/ajcn\/70.6.1069","article-title":"Green and yellow vegetables can maintain body stores of vitamin A in Chinese children","volume":"70","author":"Tang","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ajcn\/72.2.455","article-title":"Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status","volume":"72","author":"Ribaya-Mercado","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib45","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1177\/1535370217728500","article-title":"Provitamin A-biofortified maize consumption increases serum xanthophylls and 13C-natural abundance of retinol in Zambian children","volume":"242","author":"Sheftel","year":"2017","journal-title":"Exp Biol Med"},{"key":"10.1093\/advances\/nmy036_bib46","series-title":"Vitamins and hormones","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0083-6729(06)75007-5","article-title":"Use of model-based compartmental analysis to study vitamin A kinetics and metabolism","author":"Cifelli","year":"2007"},{"key":"10.1093\/advances\/nmy036_bib47","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.3945\/jn.116.233676","article-title":"A retinol isotope dilution equation predicts both group and individual total body vitamin A stores in adults based on data from an early postdosing blood sample","volume":"146","author":"Green","year":"2016","journal-title":"J Nutr"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1024\/0300-9831\/a000181","article-title":"Evaluation of the \u201cOlson equation,\u201d an isotope dilution method for estimating vitamin A stores","volume":"84","author":"Green","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib49","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/ajcn\/77.3.681","article-title":"Population-based plasma kinetics of an oral dose of [2H4] retinyl acetate among preschool-aged, Peruvian children","volume":"77","author":"Haskell","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/nxy095","article-title":"Duration of retinol isotope dilution studies with compartmental modeling affects model complexity, kinetic parameters, and calculated vitamin A stores in US women","volume":"148","author":"Gannon","year":"2018","journal-title":"J Nutr."},{"key":"10.1093\/advances\/nmy036_bib51","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3945\/jn.117.256974","article-title":"Use of a \u201csuper-child\u201d approach to assess the vitamin A equivalence of Moringa oleifera leaves, develop a compartmental model for vitamin A kinetics, and estimate vitamin A total body stores in young Mexican children","volume":"147","author":"Lopez-Teros","year":"2017","journal-title":"J Nutr"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1024\/0300-9831\/a000185","article-title":"Research recommendations for applying vitamin A-labelled isotope dilution techniques to improve human vitamin A nutrition","volume":"84","author":"Tanumihardjo","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"issue":"Suppl 2","key":"10.1093\/advances\/nmy036_bib53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/0379572116630642","article-title":"Current capabilities and limitations of stable isotope techniques and applied mathematical equations in determining whole-body vitamin A status","volume":"37","author":"Lietz","year":"2016","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib54","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/ajcn\/80.5.1291","article-title":"Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A","volume":"80","author":"Ribaya-Mercado","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3945\/jn.112.165506","article-title":"Vitamin A-fortified milk increases total body vitamin A stores in Mexican preschoolers","volume":"143","author":"Lopez-Teros","year":"2013","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib56","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3945\/ajcn.114.087379","article-title":"Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial","volume":"100","author":"Gannon","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib57","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jocd.2013.08.016","article-title":"Vitamin A and bone health: the balancing act","volume":"16","author":"Tanumihardjo","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1093\/advances\/nmy036_bib58","series-title":"Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","first-page":"82","article-title":"Vitamin A","year":"2001"},{"key":"10.1093\/advances\/nmy036_bib59","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/15648265070282S206","article-title":"From harvest to health: challenges for developing biofortified staple foods and determining their impact on micronutrient status","volume":"28","author":"Hotz","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib60","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/nu9030246","article-title":"Genetic variations associated with vitamin A status and vitamin A bioavailability","volume":"9","author":"Borel","year":"2017","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmy036_bib61","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/ajcn\/68.5.1058","article-title":"Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and beta-carotene in schoolchildren in Indonesia","volume":"68","author":"de Pee","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib62","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1074\/jbc.M112.444240","article-title":"Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX","volume":"288","author":"Lobo","year":"2013","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1024\/0300-9831\/a000183","article-title":"Vitamin A value of plant food provitamin A\u2014evaluated by the stable isotope technologies","volume":"84","author":"Tang","year":"2014","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1541-4337.2010.00117.x","article-title":"Maize: a paramount staple crop in the context of global nutrition","volume":"9","author":"Nuss","year":"2010","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib65","doi-asserted-by":"crossref","first-page":"511S","DOI":"10.1093\/jn\/132.3.511S","article-title":"Evaluating the impact of plant biofortification on human nutrition","volume":"132","author":"King","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib66","series-title":"Carotenoids and human health","first-page":"303","article-title":"Orange sweetpotato as a staple or complementary food","author":"van Jaarsveld","year":"2013"},{"key":"10.1093\/advances\/nmy036_bib67","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/ajcn\/80.3.705","article-title":"Daily consumption of Indian spinach (Basella alba) or sweet potatoes has a positive effect on total-body vitamin A stores in Bangladeshi men","volume":"80","author":"Haskell","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib68","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/jn\/137.5.1320","article-title":"A food-based approach introducing orange-fleshed sweet potatoes increased vitamin A intake and serum retinol concentrations in young children in rural Mozambique","volume":"137","author":"Low","year":"2007","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib69","series-title":"Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations","year":"2011"},{"key":"10.1093\/advances\/nmy036_bib70","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3945\/jn.111.151829","article-title":"Introduction of \u03b2-carotene-rich orange sweet potato in rural Uganda resulted in increased vitamin A intakes among children and women and improved vitamin A status among children","volume":"142","author":"Hotz","year":"2012","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib71","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/jn\/136.10.2562","article-title":"Carotenoid-biofortified maize maintains adequate vitamin A status in Mongolian gerbils","volume":"136","author":"Howe","year":"2006","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib72","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1021\/jf800816q","article-title":"The xanthophyll composition of biofortified maize (Zea mays sp.) does not influence the bioefficacy of provitamin A carotenoids in Mongolian gerbils (Meriones unguiculatus)","volume":"56","author":"Davis","year":"2008","journal-title":"J Agr Food Chem"},{"key":"10.1093\/advances\/nmy036_bib73","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1017\/S0007114508944123","article-title":"\u03b2-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils (Meriones unguiculatus) better than or equal to \u03b2-carotene supplements","volume":"100","author":"Davis","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmy036_bib74","series-title":"Carotenoids and human health","first-page":"271","article-title":"Biofortification of maize with provitamin A carotenoids","author":"Pixley","year":"2013"},{"key":"10.1093\/advances\/nmy036_bib75","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3945\/ajcn.2010.29802","article-title":"Vitamin A equivalence of the \u03b2-carotene in \u03b2-carotene-biofortified maize porridge consumed by women","volume":"92","author":"Li","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib76","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3945\/ajcn.110.006486","article-title":"Yellow maize with high \u03b2-carotene is an effective source of vitamin A in healthy Zimbabwean men","volume":"94","author":"Muzhingi","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib77","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/156482651203300106","article-title":"Comparative intake of white- versus orange-colored maize by Zambian children in the context of promotion of biofortified maize","volume":"33","author":"Nuss","year":"2012","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib78","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3945\/jn.114.192245","article-title":"The acute phase response affected traditional measures of micronutrient status in rural Zambian children during a randomized, controlled feeding trial","volume":"144","author":"Bresnahan","year":"2014","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib79","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3181\/0806-RM-199","article-title":"13C Natural abundance in serum retinol acts as a biomarker for increases in dietary provitamin A","volume":"234","author":"Howe","year":"2009","journal-title":"Exp Biol Med"},{"key":"10.1093\/advances\/nmy036_bib80","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3945\/jn.116.230300","article-title":"13C Natural abundance of serum retinol is a novel biomarker for evaluating provitamin A carotenoid-biofortified maize consumption in male Mongolian gerbils","volume":"146","author":"Gannon","year":"2016","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib81","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3945\/jn.113.175679","article-title":"High-provitamin A carotenoid (orange) maize increases hepatic vitamin A reserves of offspring in a vitamin A-depleted sow-piglet model during lactation","volume":"143","author":"Heying","year":"2013","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib82","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jhealeco.2012.01.002","article-title":"Using a discrete choice experiment to elicit the demand for a nutritious food: willingness-to-pay for orange maize in rural Zambia","volume":"31","author":"Meenakshi","year":"2012","journal-title":"J Health Econ"},{"key":"10.1093\/advances\/nmy036_bib83","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1093\/jn\/137.10.2229","article-title":"\u03b2-carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to \u03b2-carotene content in different genotypes of cassava","volume":"137","author":"Thakkar","year":"2007","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib84","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1017\/S0007114508184720","article-title":"Cassava with enhanced \u03b2-carotene maintains adequate vitamin A status in Mongolian gerbils (Meriones unguiculatus) despite substantial cis-isomer content","volume":"102","author":"Howe","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmy036_bib85","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1017\/S0007114512005004","article-title":"Biofortified cassava increases \u03b2-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women","volume":"110","author":"La Frano","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmy036_bib86","series-title":"Vitamin A equivalence of the \u03b2-carotene in biofortified cassava in women","author":"Liu","year":"2009"},{"key":"10.1093\/advances\/nmy036_bib87","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.287.5451.303","article-title":"Engineering the provitamin A (\u03b2-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm","volume":"287","author":"Ye","year":"2000","journal-title":"Science"},{"key":"10.1093\/advances\/nmy036_bib88","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nbt1082","article-title":"Improving the nutritional value of Golden Rice through increased pro-vitamin A content","volume":"23","author":"Paine","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1093\/advances\/nmy036_bib89","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3945\/ajcn.2008.27119","article-title":"Golden Rice is an effective source of vitamin A","volume":"89","author":"Tang","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib90","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3945\/an.115.010215","article-title":"Overview of the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project","volume":"7","author":"Suchdev","year":"2016","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmy036_bib91","series-title":"Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia","author":"Stoltzfus","year":"1998"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib92","doi-asserted-by":"crossref","first-page":"2978S","DOI":"10.1093\/jn\/133.9.2978S","article-title":"Iron and ascorbic acid: proposed fortification levels and recommended iron compounds","volume":"133","author":"Lynch","year":"2003","journal-title":"J Nutr"},{"issue":"Suppl","key":"10.1093\/advances\/nmy036_bib93","doi-asserted-by":"crossref","first-page":"858S","DOI":"10.3945\/jn.115.220079","article-title":"Biomarkers of Nutrition for Development (BOND)\u2014zinc review","volume":"146","author":"King","year":"2016","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib94","doi-asserted-by":"crossref","first-page":"480S","DOI":"10.1177\/15648265070283S306","article-title":"Conclusions of the Joint WHO\/UNICEF\/IAEA\/IZiNCG Interagency Meeting on Zinc Status Indicators","volume":"28","author":"de Benoist","year":"2007","journal-title":"Food Nutr Bull"},{"issue":"Suppl 1","key":"10.1093\/advances\/nmy036_bib95","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/15648265090301S102","article-title":"Recent advances in knowledge of zinc nutrition and human health","volume":"30","author":"Hess","year":"2009","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib96","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/ajcn\/78.3.436","article-title":"The efficacy of a local ascorbic acid-rich food in improving iron absorption from Mexican diets: a field study using stable isotopes","volume":"78","author":"Diaz","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib97","series-title":"Assessment of iron bioavailability in humans using stable iron isotope techniques","year":"2012"},{"key":"10.1093\/advances\/nmy036_bib98","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/sj.ejcn.1602125","article-title":"Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce","volume":"59","author":"Walczyk","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/advances\/nmy036_bib99","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1024\/0300-9831.74.4.294","article-title":"Effect of ascorbic acid and particle size on iron absorption from ferric pyrophosphate in adult women","volume":"74","author":"Fidler","year":"2004","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib100","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/jn\/135.7.1790","article-title":"High resolution inductively coupled plasma mass spectrometry allows rapid assessment of iron absorption in infants and children","volume":"135","author":"Chen","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib101","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.3945\/jn.110.122812","article-title":"Plasma zinc concentration responds rapidly to the initiation and discontinuation of short-term zinc supplementation in healthy men","volume":"140","author":"Wessells","year":"2010","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib102","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02784403","article-title":"Polyatomics in zinc isotope ratio analysis of plasma samples by inductively coupled plasma-mass spectrometry and applicability of nonextracted samples for zinc kinetics","volume":"68","author":"Ramanujam","year":"1999","journal-title":"Biol Trace Elem Res"},{"key":"10.1093\/advances\/nmy036_bib103","doi-asserted-by":"crossref","first-page":"1374S","DOI":"10.1093\/jn\/130.5.1374S","article-title":"Overview of zinc absorption and excretion in the human gastrointestinal tract","volume":"130","author":"Krebs","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib104","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.3945\/jn.109.107755","article-title":"The quantity of zinc absorbed from wheat in adult women is enhanced by biofortification","volume":"139","author":"Rosado","year":"2009","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3945\/jn.113.178715","article-title":"Absorbed zinc and exchangeable zinc pool size are greater in Pakistani infants receiving traditional complementary foods with zinc-fortified micronutrient powder","volume":"144","author":"Ariff","year":"2014","journal-title":"J Nutr"},{"issue":"Suppl 4","key":"10.1093\/advances\/nmy036_bib106","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/mcn.12167","article-title":"Iron bioavailability in 8-24-month-old Thai children from a micronutrient-fortified quick-cooking rice containing ferric ammonium citrate or a mixture of ferrous sulphate and ferric sodium ethylenediaminetetraacetic acid","volume":"11","author":"Chavasit","year":"2015","journal-title":"Matern Child Nutr"},{"key":"10.1093\/advances\/nmy036_bib107","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S0007114517002045","article-title":"In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children","volume":"118","author":"Herter-Aeberli","year":"2017","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmy036_bib108","first-page":"254","article-title":"Jardin\u00f3polis without anemia, first stage: anthropometric and iron nutrition status evaluation (Portuguese)","volume":"25","author":"de Almeida","year":"2007","journal-title":"Rev Paul Pediatr"},{"issue":"Suppl 3","key":"10.1093\/advances\/nmy036_bib109","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/jn\/133.3.948S","article-title":"Biomarkers of trace mineral intake and status","volume":"133","author":"Hambidge","year":"2003","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib110","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/tropej\/fmt071","article-title":"Assessment of drinking water fortification with iron plus ascorbic acid or ascorbic acid alone in daycare centers as a strategy to control iron-deficiency anemia and iron deficiency: a randomized blind clinical study","volume":"60","author":"de Almeida","year":"2014","journal-title":"J Trop Pediatr"},{"key":"10.1093\/advances\/nmy036_bib111","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1024\/0300-9831.75.6.371","article-title":"The usefulness of in vitro models to predict the bioavailability of iron and zinc: a consensus statement from the HarvestPlus expert consultation","volume":"75","author":"Fairweather-Tait","year":"2005","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/advances\/nmy036_bib112","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/156482650702800309","article-title":"An analysis of the etiology of anemia and iron deficiency in young women of low socioeconomic status in Bangalore, India","volume":"28","author":"Thankachan","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.1093\/advances\/nmy036_bib113","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/jn\/135.12.2823","article-title":"Iron-biofortified rice improves the iron stores of nonanemic Filipino women","volume":"135","author":"Haas","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib114","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3945\/jn.111.149286","article-title":"Stable iron isotope studies in Rwandese women indicate that the common bean has limited potential as a vehicle for iron biofortification","volume":"142","author":"Petry","year":"2012","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib115","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3945\/jn.112.169169","article-title":"Total zinc absorption from a diet containing either conventional rice or higher-zinc rice does not differ among Bangladeshi preschool children","volume":"143","author":"Islam","year":"2013","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib116","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3945\/jn.114.204933","article-title":"Zinc absorption from biofortified maize meets the requirements of young rural Zambian children","volume":"145","author":"Chomba","year":"2015","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib117","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3945\/jn.113.176677","article-title":"Biofortification of pearl millet with iron and zinc in a randomized controlled trial increases absorption of these minerals above physiologic requirements in young children","volume":"143","author":"Kodkany","year":"2013","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib118","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3945\/an.110.000182","article-title":"Quality protein maize for Africa: closing the protein inadequacy gap in vulnerable populations","volume":"2","author":"Nuss","year":"2011","journal-title":"Adv Nutr"},{"key":"10.1093\/advances\/nmy036_bib119","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1475-2891-12-131","article-title":"Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana","volume":"12","author":"Owusu-Agyei","year":"2013","journal-title":"Nutr J"},{"key":"10.1093\/advances\/nmy036_bib120","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3945\/jn.110.123059","article-title":"The current high prevalence of dietary zinc inadequacy among children and women in rural Bangladesh could be substantially ameliorated by zinc biofortification of rice","volume":"140","author":"Arsenault","year":"2010","journal-title":"J Nutr"},{"key":"10.1093\/advances\/nmy036_bib121","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/nu4060517","article-title":"Zinc biofortification of rice in China: a simulation of zinc intake with different dietary patterns","volume":"4","author":"Qin","year":"2012","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmy036_bib122","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jplph.2010.05.003","article-title":"Identification of putative target genes to manipulate Fe and Zn concentrations in rice grains","volume":"167","author":"Sperotto","year":"2010","journal-title":"J Plant Physiol"},{"key":"10.1093\/advances\/nmy036_bib123","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/1535370213510661","article-title":"Quantification of food and nutrient intakes in Zambian children with and without malaria under controlled feeding conditions","volume":"239","author":"Bresnahan","year":"2014","journal-title":"Exp Biol Med"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322012571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322012571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/advances\/article-pdf\/9\/5\/625\/25738497\/nmy036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:12:26Z","timestamp":1761873146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831322012571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":123,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S2161831322012571"],"URL":"https:\/\/doi.org\/10.1093\/advances\/nmy036","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Stable Isotopes to Evaluate Bioefficacy of Provitamin A Carotenoids, Vitamin A Status, and Bioavailability of Iron and Zinc","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/advances\/nmy036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Nutrition","name":"copyright","label":"Copyright"}]}}