{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:12:56Z","timestamp":1790046776096,"version":"4.0.1"},"reference-count":108,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":757,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1093\/advances\/nmz080","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T23:09:22Z","timestamp":1562022562000},"page":"160-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-2121","authenticated-orcid":false,"given":"Karla A","family":"Bascu\u00f1\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda","family":"Roncoroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Doneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Elli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/advances\/nmz080_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management","volume":"141","author":"Sicherer","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1093\/advances\/nmz080_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1093\/advances\/nmz080_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Short analytical review","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1093\/advances\/nmz080_bib4","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.3390\/nu7085314","article-title":"Intestinal microbiota and celiac disease: Cause, consequence or co-evolution?","volume":"17","author":"Cenit","year":"2015","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmz080_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2015.01.022","article-title":"Gut microbiota biomodulators, when the stork comes by the scalpel","volume":"7","author":"Miniello","year":"2015","journal-title":"Clin Chim Acta"},{"key":"10.1093\/advances\/nmz080_bib6","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1017\/S0007114509371767","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects","volume":"102","author":"De\u00a0Palma","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmz080_bib7","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","article-title":"Diet and the intestinal microbiome: Associations, functions, and implications for health and disease","volume":"146","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1093\/advances\/nmz080_bib8","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.biotechadv.2016.08.003","article-title":"The gut microbiota: A treasure for human health","volume":"34","author":"Li","year":"2016","journal-title":"Biotechnol Adv"},{"key":"10.1093\/advances\/nmz080_bib9","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur J Nutr"},{"key":"10.1093\/advances\/nmz080_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nri.2017.7","article-title":"Dysbiosis and the immune system","volume":"17","author":"Levy","year":"2017","journal-title":"Nat Rev Immunol"},{"issue":"Suppl 2","key":"10.1093\/advances\/nmz080_bib12","first-page":"28","article-title":"Microbiome and Gluten","volume":"67","author":"Sanz","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"10.1093\/advances\/nmz080_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac disease","volume":"391","author":"Lebwohl","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"10.1093\/advances\/nmz080_bib14","doi-asserted-by":"crossref","first-page":"G996","DOI":"10.1152\/ajpgi.00136.2002","article-title":"Intestinal digestive resistance of immunodominant gliadin peptides","volume":"283","author":"Hausch","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1093\/advances\/nmz080_bib15","first-page":"9","article-title":"Differences between the fecal microbiota of coeliac infants and healthy controls","volume":"8","author":"Collado","year":"2007","journal-title":"Curr Issues Intest Microbiol"},{"key":"10.1093\/advances\/nmz080_bib16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1574-695X.2007.00337.x","article-title":"Differences in faecal bacterial communities in coeliac and healthy children as detected by PCR and denaturing gradient gel electrophoresis","volume":"51","author":"Sanz","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1093\/advances\/nmz080_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2180-10-63","article-title":"Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children","volume":"10","author":"De\u00a0Palma","year":"2010","journal-title":"BMC Microbiol"},{"key":"10.1093\/advances\/nmz080_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ibd.21830","article-title":"Differences of small intestinal bacteria populations in adults and children with\/without celiac disease: Effect of age, gluten diet, and disease","volume":"18","author":"Nistal","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1093\/advances\/nmz080_bib19","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1111\/jam.13111","article-title":"Study of duodenal bacterial communities by 16S rRNA gene analysis in adults with active celiac disease vs non-celiac disease controls","volume":"120","author":"Nistal","year":"2016","journal-title":"J Appl Microbiol"},{"issue":"Pt 12","key":"10.1093\/advances\/nmz080_bib20","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1099\/jmm.0.47410-0","article-title":"Imbalance in the composition of the duodenal microbiota of children with coeliac disease","volume":"56","author":"Nadal","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1093\/advances\/nmz080_bib21","doi-asserted-by":"crossref","first-page":"e61608","DOI":"10.1371\/journal.pone.0061608","article-title":"Higher prevalence and abundance of Bdellovibrio bacteriovorus in the human gut of healthy subjects","volume":"8","author":"Iebba","year":"2013","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmz080_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/08830185.2011.599084","article-title":"Unraveling the ties between celiac disease and intestinal microbiota","volume":"30","author":"Sanz","year":"2011","journal-title":"Int Rev Immunol"},{"key":"10.1093\/advances\/nmz080_bib23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/jexbot\/53.370.947","article-title":"Cereal seed storage proteins: structures, properties and role in grain utilization","volume":"53","author":"Shewry","year":"2002","journal-title":"J Exp Bot"},{"key":"10.1093\/advances\/nmz080_bib24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/jxb\/erp058","article-title":"Wheat","volume":"60","author":"Shewry","year":"2009","journal-title":"J Exp Bot"},{"key":"10.1093\/advances\/nmz080_bib25","unstructured":">25 Feldman M,. Origin of cultivated wheat. In: Alin PB, William JA, editors. The World Wheat Book: A History of Wheat Breeding. London: TCA VOC; 2001. p. 3\u201356."},{"key":"10.1093\/advances\/nmz080_bib26","first-page":"S14","article-title":"From the neolithic revolution to gluten intolerance: benefits and problems associated with the cultivation of wheat","volume":"24","author":"Greco","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1093\/advances\/nmz080_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fm.2006.07.004","article-title":"Chemistry of gluten proteins","volume":"24","author":"Wieser","year":"2007","journal-title":"Food Microbiol"},{"key":"10.1093\/advances\/nmz080_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00249-009-0529-7","article-title":"Structure and heterogeneity of gliadin: A hydrodynamic evaluation","volume":"39","author":"Ang","year":"2010","journal-title":"Eur Biophys J"},{"key":"10.1093\/advances\/nmz080_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2229-9-41","article-title":"Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: A study with Chinese Spring deletion lines","volume":"7","author":"Van\u00a0Den\u00a0Broeck","year":"2009","journal-title":"BMC Plant Biol"},{"key":"10.1093\/advances\/nmz080_bib30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jgh.13703","article-title":"What is gluten?","volume":"32","author":"Biesiekierski","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1093\/advances\/nmz080_bib31","first-page":"1319","article-title":"[History of gluten and its effects on celiac disease]","volume":"138","author":"Parada","year":"2010","journal-title":"Rev Med Chil"},{"key":"10.1093\/advances\/nmz080_bib32","doi-asserted-by":"crossref","first-page":"e13264","DOI":"10.1371\/journal.pone.0013264","article-title":"Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity","volume":"5","author":"Helmerhorst","year":"2010","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmz080_bib33","doi-asserted-by":"crossref","first-page":"e24455","DOI":"10.1371\/journal.pone.0024455","article-title":"Identification of rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract","volume":"6","author":"Zamakhchari","year":"2011","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmz080_bib34","doi-asserted-by":"crossref","first-page":"E386","DOI":"10.1111\/1469-0691.12249","article-title":"The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity","volume":"19","author":"Fernandez-Feo","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1093\/advances\/nmz080_bib35","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1021\/pr050173t","article-title":"Identification and analysis of multivalent proteolytically resistant peptides from gluten: Implications for Celiac Sprue","volume":"4","author":"Shan","year":"2005","journal-title":"J Proteome Res"},{"key":"10.1093\/advances\/nmz080_bib36","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.1074129","article-title":"Structural basis for gluten intolerance in Celiac Sprue","volume":"297","author":"Shan","year":"2002","journal-title":"Science"},{"key":"10.1093\/advances\/nmz080_bib37","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(59)92051-3","article-title":"Gluten-induced enteropathy the effect of partially digested gluten","volume":"2","author":"Frazer","year":"1959","journal-title":"Lancet"},{"key":"10.1093\/advances\/nmz080_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/open.201700197","article-title":"Translational chemistry meets gluten-related disorders","volume":"7","author":"Lammers","year":"2018","journal-title":"ChemistryOpen"},{"key":"10.1093\/advances\/nmz080_bib39","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1053\/j.gastro.2015.07.013","article-title":"Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease","volume":"149","author":"Hardy","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1093\/advances\/nmz080_bib40","doi-asserted-by":"crossref","unstructured":">40 Ganapathy V,. Chapter 59 - Protein Digestion and Absorption. In: Johnson LR, Ghishan FK, Kaunitz JD, Merchant JL, Said HM, Wood JDBT, editors. Physiology of the Gastrointestinal Tract (Fifth Edition). Boston: Academic Press; 2012. p. 1595\u2013623.","DOI":"10.1016\/B978-0-12-382026-6.00059-2"},{"key":"10.1093\/advances\/nmz080_bib41","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMcibr1706917","article-title":"Celiac disease and autoimmunity \u2014 the missing ingredient","volume":"377","author":"Rosenbaum","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1093\/advances\/nmz080_bib42","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/j.gastro.2009.09.008","article-title":"Celiac disease: from pathogenesis to novel therapies","volume":"137","author":"Schuppan","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1093\/advances\/nmz080_bib43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ncpgasthep0111","article-title":"Future therapeutic options for celiac disease","volume":"2","author":"Sollid","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1093\/advances\/nmz080_bib44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.imlet.2005.02.017","article-title":"Adaptive and innate immune responses in celiac disease","volume":"99","author":"Gianfrani","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1093\/advances\/nmz080_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/mi.2008.75","article-title":"Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis","volume":"2","author":"Meresse","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1093\/advances\/nmz080_bib46","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/nyas.13343","article-title":"Zonulin transgenic mice show altered gut permeability and increased morbidity\/mortality in the DSS colitis model","volume":"1397","author":"Sturgeon","year":"2017","journal-title":"Ann N Y Acad Sci"},{"key":"10.1093\/advances\/nmz080_bib47","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1365-2036.2008.03669.x","article-title":"Systematic review: Tolerable amount of gluten for people with coeliac disease","volume":"27","author":"Akobeng","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1093\/advances\/nmz080_bib48","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajcn\/85.1.160","article-title":"A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease","volume":"85","author":"Catassi","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmz080_bib49","unstructured":">49 Food and Drug Administration. Health hazard assessment for gluten exposure in individuals with celiac disease: determination of tolerable daily intake levels and levels of concern for gluten. Office of Food Safety Center of Food Safety and Applied Nutrition Food and Drug Administration, U.S.A.; 2011."},{"key":"10.1093\/advances\/nmz080_bib50","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/gutjnl-2012-302196","article-title":"Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease","volume":"62","author":"Leffler","year":"2013","journal-title":"Gut"},{"key":"10.1093\/advances\/nmz080_bib51","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3390\/nu10121927","article-title":"Gluten immunogenic peptides as standard for the evaluation of potential harmful prolamin content in food and human specimen","volume":"10","author":"Cebolla","year":"2018","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmz080_bib52","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-016-0307-y","article-title":"The healthy human microbiome","volume":"8","author":"Lloyd-Price","year":"2016","journal-title":"Genome Med"},{"key":"10.1093\/advances\/nmz080_bib53","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den\u00a0Besten","year":"2013","journal-title":"J Lipid Res"},{"key":"10.1093\/advances\/nmz080_bib54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Ba\u00fcmler","year":"2016","journal-title":"Nature"},{"key":"10.1093\/advances\/nmz080_bib55","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Science"},{"key":"10.1093\/advances\/nmz080_bib56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2012.10.007","article-title":"Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications","volume":"69","author":"Natividad","year":"2013","journal-title":"Pharmacol Res"},{"key":"10.1093\/advances\/nmz080_bib57","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem J"},{"key":"10.1093\/advances\/nmz080_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/gut.42.1.2","article-title":"Ecological control of the gastrointestinal tract. The role of probiotic flora","volume":"42","author":"Bengmark","year":"1998","journal-title":"Gut"},{"key":"10.1093\/advances\/nmz080_bib59","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science"},{"key":"10.1093\/advances\/nmz080_bib60","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"10.1093\/advances\/nmz080_bib61","doi-asserted-by":"crossref","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol"},{"key":"10.1093\/advances\/nmz080_bib62","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/ajcn\/25.12.1292","article-title":"Introduction to intestinal microecology","volume":"25","author":"Luckey","year":"1972","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmz080_bib63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/PLMI.S121487","article-title":"Recent findings within the microbiota\u2013gut\u2013brain\u2013endocrine metabolic interactome","volume":"9","author":"Obrenovich","year":"2017","journal-title":"Pathol Lab Med Int"},{"key":"10.1093\/advances\/nmz080_bib64","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/cmi.12585","article-title":"Microbes and the mind: Emerging hallmarks of the gut microbiota-brain axis","volume":"18","author":"Bauer","year":"2016","journal-title":"Cell Microbiol"},{"key":"10.1093\/advances\/nmz080_bib65","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3389\/fmicb.2018.01835","article-title":"The human gut microbiome \u2013 a potential controller of wellness and disease","volume":"9","author":"Kho","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1093\/advances\/nmz080_bib66","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1111\/j.1462-2920.2009.01982.x","article-title":"Towards the human intestinal microbiota phylogenetic core","volume":"11","author":"Tap","year":"2009","journal-title":"Environ Microbiol"},{"key":"10.1093\/advances\/nmz080_bib67","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1058709","article-title":"Commensal host-bacterial relationships in the gut","volume":"292","author":"Hooper\u00a0L","year":"2001","journal-title":"Science"},{"key":"10.1093\/advances\/nmz080_bib68","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/j.1365-2222.2009.03326.x","article-title":"Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses: gut microbiota and immune responses","volume":"39","author":"Sj\u00f6gren","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1093\/advances\/nmz080_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/nutrit\/nuv019","article-title":"Microbiota and the gut-brain axis","volume":"73","author":"Bienenstock","year":"2015","journal-title":"Nutr Rev"},{"key":"10.1093\/advances\/nmz080_bib70","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000443360","article-title":"Effects of antibiotics on gut microbiota","volume":"34","author":"Lange","year":"2016","journal-title":"Dig Dis"},{"key":"10.1093\/advances\/nmz080_bib71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2016.02.001","article-title":"Dysbiosis in gastrointestinal disorders","volume":"30","author":"Chang","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib72","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nm.4185","article-title":"Signals from the gut microbiota to distant organs in physiology and disease","volume":"22","author":"Schroeder","year":"2016","journal-title":"Nat Med"},{"key":"10.1093\/advances\/nmz080_bib73","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/nutrit\/nuv039","article-title":"Potential role of the intestinal microbiota in programming health and disease","volume":"73","author":"Goulet","year":"2015","journal-title":"Nutr Rev"},{"key":"10.1093\/advances\/nmz080_bib74","doi-asserted-by":"crossref","first-page":"e1857","DOI":"10.1371\/journal.pone.0001857","article-title":"Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques","volume":"3","author":"Bethune","year":"2008","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmz080_bib75","doi-asserted-by":"crossref","first-page":"E684","DOI":"10.3390\/nu8110684","article-title":"Dietary gluten-induced gut dysbiosis is accompanied by selective upregulation of microRNAs with intestinal tight junction and bacteria-binding motifs in a rhesus macaque model of celiac disease","volume":"8","author":"Mohan","year":"2016","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmz080_bib76","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.resmic.2017.04.008","article-title":"Gluten-degrading bacteria are present in the human small intestine of healthy volunteers and celiac patients","volume":"168","author":"Herr\u00e1n","year":"2017","journal-title":"Res Microbiol"},{"key":"10.1093\/advances\/nmz080_bib77","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.2008.167296","article-title":"Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa","volume":"58","author":"Bernardo","year":"2009","journal-title":"Gut"},{"key":"10.1093\/advances\/nmz080_bib78","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.phrs.2013.01.003","article-title":"Re-print of \u201cintestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host\u201d","volume":"69","author":"Davila","year":"2013","journal-title":"Pharmacol Res"},{"key":"10.1093\/advances\/nmz080_bib79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2672.1988.tb02427.x","article-title":"Contribution of the microflora to proteolysis in the human large intestine","volume":"64","author":"Macfarlane","year":"1988","journal-title":"J Appl Bacteriol"},{"key":"10.1093\/advances\/nmz080_bib80","doi-asserted-by":"crossref","first-page":"e30744","DOI":"10.1371\/journal.pone.0030744","article-title":"Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model","volume":"7","author":"Laparra","year":"2012","journal-title":"PLoS One"},{"key":"10.1093\/advances\/nmz080_bib81","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/jcp.2010.076950","article-title":"Intestinal Bacteroides species associated with coeliac disease","volume":"63","author":"S\u00e1nchez","year":"2010","journal-title":"J Clin Pathol"},{"key":"10.1093\/advances\/nmz080_bib82","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcb.22459","article-title":"Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion","volume":"109","author":"Laparra","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1093\/advances\/nmz080_bib83","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3945\/ajcn.111.026708","article-title":"Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces","volume":"95","author":"Comino","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/advances\/nmz080_bib84","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/1574-6941.12295","article-title":"Diversity of the cultivable human gut microbiome involved in gluten metabolism: Isolation of microorganisms with potential interest for coeliac disease","volume":"88","author":"Caminero","year":"2014","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1093\/advances\/nmz080_bib85","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cyto.2009.08.003","article-title":"Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity","volume":"48","author":"D'Arienzo","year":"2009","journal-title":"Cytokine"},{"key":"10.1093\/advances\/nmz080_bib86","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.gastro.2016.06.041","article-title":"Duodenal bacteria from patients with celiac disease and healthy subjects distinctly affect gluten breakdown and immunogenicity","volume":"151","author":"Caminero","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1093\/advances\/nmz080_bib87","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41467-019-09037-9","article-title":"Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2","volume":"10","author":"Caminero","year":"2019","journal-title":"Nat Commun"},{"key":"10.1093\/advances\/nmz080_bib88","first-page":"644","article-title":"T-cell repertoires in refractory coeliac disease","volume":"67","author":"Ritter","year":"2018","journal-title":"Gut"},{"key":"10.1093\/advances\/nmz080_bib89","doi-asserted-by":"crossref","first-page":"e03316","DOI":"10.1128\/AEM.03330-16","article-title":"Salivary gluten degradation and oral microbial profiles in healthy individuals and celiac disease patients","volume":"83","author":"Tian","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"10.1093\/advances\/nmz080_bib90","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"10.1093\/advances\/nmz080_bib91","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1093\/advances\/nmz080_bib92","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1572-0241.2004.04157.x","article-title":"Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease","volume":"99","author":"Forsberg","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib93","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2180-8-232","article-title":"Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease","volume":"8","author":"Collado","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1093\/advances\/nmz080_bib94","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1038\/ajg.2009.524","article-title":"Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease","volume":"104","author":"Ou","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib95","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1128\/AEM.00563-12","article-title":"Discerning the role of bacteroides fragilis in celiac disease pathogenesis","volume":"78","author":"S\u00e1nchez","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"10.1093\/advances\/nmz080_bib96","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-230X-13-113","article-title":"Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease","volume":"13","author":"Cheng","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib97","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/MIB.0b013e31828029a9","article-title":"The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease","volume":"19","author":"Wacklin","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1093\/advances\/nmz080_bib98","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1128\/AEM.00869-13","article-title":"Duodenal-mucosal bacteria associated with celiac disease in children","volume":"79","author":"S\u00e1nchez","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"10.1093\/advances\/nmz080_bib99","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/ajg.2014.355","article-title":"Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet","volume":"109","author":"Wacklin","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib100","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1128\/AEM.00362-14","article-title":"Salivary microbiota and metabolome associated with celiac disease","volume":"80","author":"Francavilla","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1093\/advances\/nmz080_bib101","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1017\/S0007114515002767","article-title":"Differences in gluten metabolism among healthy volunteers, coeliac disease patients and first-degree relatives","volume":"114","author":"Caminero","year":"2015","journal-title":"Br J Nutr"},{"key":"10.1093\/advances\/nmz080_bib102","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1139\/cjm-2014-0472","article-title":"Decrease in lactobacilli in the intestinal microbiota of celiac children with a gluten-free diet, and selection of potentially probiotic strains","volume":"61","author":"Lorenzo\u00a0Pisarello","year":"2015","journal-title":"Can J Microbiol"},{"key":"10.1093\/advances\/nmz080_bib103","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/00365521.2018.1444788","article-title":"Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity","volume":"53","author":"Rintala","year":"2018","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib104","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3390\/nu10111641","article-title":"First insights into the gut microbiota of Mexican patients with celiac disease and non-celiac gluten sensitivity","volume":"10","author":"Garcia-Mazcorro","year":"2018","journal-title":"Nutrients"},{"key":"10.1093\/advances\/nmz080_bib105","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fmicb.2019.00164","article-title":"Comparison of small gut and whole gut microbiota of first-degree relatives with adult celiac disease patients and controls","volume":"8","author":"Bodkhe","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1093\/advances\/nmz080_bib106","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1651-2227.2000.tb01210.x","article-title":"Epidemic of coeliac disease in Swedish children","volume":"89","author":"Ivarsson","year":"2000","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"10.1093\/advances\/nmz080_bib107","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ajg.2016.95","article-title":"Metagenomics reveals dysbiosis and a potentially pathogenic N. flavescens strain in duodenum of adult celiac patients","volume":"111","author":"D'Argenio","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/advances\/nmz080_bib108","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/gutjnl-2014-306931","article-title":"The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease","volume":"64","author":"Olivares","year":"2015","journal-title":"Gut"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322002435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322002435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/advances\/advance-article-pdf\/doi\/10.1093\/advances\/nmz080\/29115312\/nmz080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:58:47Z","timestamp":1761872327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831322002435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S2161831322002435"],"URL":"https:\/\/doi.org\/10.1093\/advances\/nmz080","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/advances\/nmz080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 Copyright \u00a9 American Society for Nutrition 2019. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}