{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:00:13Z","timestamp":1777291213490,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Statins are widely prescribed in the treatment of hypercholesterolemia. While their efficacy in the secondary prevention of vascular events is proven, their safety profile in older patients with multiple co-morbidities and polypharmacy remains questionable. Although rare, antihydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is a severe adverse effect of statins, manifesting as myalgias, proximal muscle weakness, muscle cell necrosis and rhabdomyolysis. We report an uncommon case of an autopsy-proven anti-HMGCR necrotising myopathy predominately affecting pharyngeal muscles in an older patient, leading to dysphagia, pneumonia and death within 3 weeks from onset. Clinicians should screen for dysphagia in any patient with suspected anti-HMGCR myopathy, order an anti-HMGCR antibody titre and consider prompt immunosupressive therapy.<\/jats:p>","DOI":"10.1093\/ageing\/afaa038","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T04:26:16Z","timestamp":1580963176000},"page":"883-884","source":"Crossref","is-referenced-by-count":5,"title":["Statin-induced autoimmune necrotizing myopathy with pharyngeal muscles involvement"],"prefix":"10.1093","volume":"49","author":[{"given":"Nicolas","family":"Mirlesse","sequence":"first","affiliation":[{"name":"Department of Internal Medicine of the Aged, Trois-Ch\u00eane Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof","family":"Egervari","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland"},{"name":"Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Bornand","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Lecluse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine of the Aged, Trois-Ch\u00eane Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A","family":"Lobrinus","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Scheffler","sequence":"additional","affiliation":[{"name":"Department of Radiology, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Serratrice","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine of the Aged, Trois-Ch\u00eane Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Prendki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine of the Aged, Trois-Ch\u00eane Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Cuvelier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine of the Aged, Trois-Ch\u00eane Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"key":"2020082411072535200_ref1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.jacc.2016.02.071","article-title":"Statin-associated side effects","volume":"67","author":"Thompson","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2020082411072535200_ref2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00228-018-2589-z","article-title":"Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase","volume":"75","author":"Essers","year":"2019","journal-title":"Eur J Clin Pharmacol"},{"key":"2020082411072535200_ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JND-170282","article-title":"Anti-HMGCR myopathy","volume":"5","author":"Mohassel","year":"2018","journal-title":"J Neuromuscul Dis"},{"key":"2020082411072535200_ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11926-018-0732-6","article-title":"Immune-mediated necrotizing myopathy","volume":"20","author":"Pinal-Fernandez","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"2020082411072535200_ref5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11926-015-0548-6","article-title":"Immune-mediated necrotizing myopathy: update on diagnosis and management","volume":"17","author":"Basharat","year":"2015","journal-title":"Curr Rheumatol Rep"}],"container-title":["Age and 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