{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:38:29Z","timestamp":1789439909666,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Health Research Nottingham Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>sarcopenia is the loss of muscle mass and quality and is diagnosed using measures of muscle strength, size and mass. We evaluated the literature on whether sarcopenia measures are predictive of motor outcomes in older people in clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>electronic databases (MEDLINE Ovid, EMBASE, CINAHL and Web of Science) were searched for articles on measures of muscle mass, volume, thickness or strength, in older people in clinical settings, which reported cross-sectional or longitudinal associations with motor outcomes. Clinical cohorts included geriatric medical inpatients and outpatients, patients with hip fracture, geriatric rehabilitation and care home residents. Motor outcomes were mobility, falls, balance and activities of daily living (ADL). Due to high study heterogeneity, standardised mean differences were used to compare strength of associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>in total, 83 articles were identified. The most frequently studied measures were grip strength (47 studies), knee extension strength (21 studies) and bioelectrical impedance analysis (18 studies). Handgrip strength (HGS) had evidence for cross-sectional associations with mobility (14 of 16 studies, 2,088 participants), balance (6 of 6 studies, 1,177 participants) and ADL independence (10 of 11 studies, 3,228 participants), and evidence of longitudinal associations with mobility (3 of 3 studies, 883 participants) and ADL independence (7 of 10 studies, 1,511 participants). There was no conclusive evidence for association with falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HS was the most studied measure and was associated with mobility, balance and ADL outcomes. There was a paucity of studies, particularly with longitudinal follow-up, measuring muscle mass, volume or thickness using gold-standard approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afaa123","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T07:09:45Z","timestamp":1591686585000},"page":"88-95","source":"Crossref","is-referenced-by-count":70,"title":["The clinical usefulness of muscle mass and strength measures in older people: a systematic review"],"prefix":"10.1093","volume":"50","author":[{"given":"Eleanor","family":"Lunt","sequence":"first","affiliation":[{"name":"Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK"},{"name":"Health Care of Older People Division, Nottingham University Hospital NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Ong","sequence":"additional","affiliation":[{"name":"Health Care of Older People Division, Nottingham University Hospital NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L","family":"Gordon","sequence":"additional","affiliation":[{"name":"Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK"},{"name":"East Midlands Collaboration for Leadership in Applied Health Research and Care, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L","family":"Greenhaff","sequence":"additional","affiliation":[{"name":"Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK"},{"name":"MRC\/ARUK Centre for Musculoskeletal Ageing Research, Nottingham, UK"},{"name":"Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R F","family":"Gladman","sequence":"additional","affiliation":[{"name":"Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK"},{"name":"Health Care of Older People Division, Nottingham University Hospital NHS Trust, Nottingham, UK"},{"name":"East Midlands Collaboration for Leadership in Applied Health Research and Care, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"2021010815105273600_ref1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"2021010815105273600_ref2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/ageing\/afu115","article-title":"Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the international sarcopenia initiative (EWGSOP and IWGS)","volume":"43","author":"Cruz-Jentoft","year":"2014","journal-title":"Age Ageing"},{"key":"2021010815105273600_ref3","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00198-017-3980-9","article-title":"Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review","volume":"28","author":"Beaudart","year":"2017","journal-title":"Osteoporos Int"},{"key":"2021010815105273600_ref4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169548","article-title":"Health outcomes of sarcopenia: a systematic review and meta-analysis","volume":"12","author":"Beaudart","year":"2017","journal-title":"PLoS One"},{"key":"2021010815105273600_ref5","doi-asserted-by":"crossref","DOI":"10.1002\/9780470743386","volume-title":"Introduction to 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