{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:28:24Z","timestamp":1761017304630,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/13\/16\/30528"],"award-info":[{"award-number":["RG\/13\/16\/30528"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research School for Primary Care Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>orthostatic hypotension (OH) that occurs within, or at, 1 minute of standing is associated with higher risk of falls, myocardial infarction, syncope and mortality, compared to OH that occurs after 1 minute of standing. Whether vitamin D deficiency increases the risk of OH is controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>this was a cross-sectional analysis of 3,620 older, community-dwelling men. Multinomial, multiple logistic regression models were used to calculate the risk of OH across categories of vitamin D status (deficient [&amp;lt;25\u00a0nmol\/l], insufficient [\u226525\u2013&amp;lt;50\u00a0nmol\/l] and sufficient [\u226550\u00a0nmol\/l]) and parathyroid hormone quintile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>men with vitamin D deficiency were more likely to have OH that occurred within 1 minute of standing in univariate logistic regression (OR 1.88, 95% CI 1.40\u20132.53) and multinomial, multiple logistic regression (OR 1.51, 95% CI 1.06\u20132.15), compared to men with sufficient levels of vitamin D. Vitamin D insufficiency was not associated with the risk of OH. Elevated parathyroid hormone was not associated with risk of OH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>the absence of an association between vitamin D insufficiency and risk of OH and the presence of an association between vitamin D deficiency and risk of OH suggest that there may be a threshold effect; it is only below a particular level of vitamin D that risk of OH is increased. In this cohort, the threshold was &amp;lt;25\u00a0nmol\/l. Future work should investigate whether treating vitamin D deficiency can improve postural blood pressure or if preventing vitamin D deficiency reduces the incidence of OH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afaa146","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T03:17:59Z","timestamp":1593573479000},"page":"198-204","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D deficiency is associated with orthostatic hypotension in older men: a cross-sectional analysis from the British Regional Heart Study"],"prefix":"10.1093","volume":"50","author":[{"given":"Artaza","family":"Gilani","sequence":"first","affiliation":[{"name":"Research Department of Primary Care and Population Health, University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheena E","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4AX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Welsh","sequence":"additional","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow G12 8TA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olia","family":"Papacosta","sequence":"additional","affiliation":[{"name":"Research Department of Primary Care and Population Health, University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy T","family":"Lennon","sequence":"additional","affiliation":[{"name":"Research Department of Primary Care and Population Health, University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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