{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:50:30Z","timestamp":1771573830624,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Delirium is a frequent condition in hospitalized older patients and it usually has a negative prognostic value. A direct effect of SARS-COV-2 on the central nervous system (CNS) has been hypothesized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the presence of delirium in older patients admitted for a suspected diagnosis of COVID-19 and its impact on in-hospital mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting and subjects<\/jats:title>\n                  <jats:p>91 patients, aged 70-years and older, admitted to an acute geriatric ward in Northern Italy from March 8th to April 17th, 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>COVID-19 cases were confirmed by reverse transcriptase-polymerase chain reaction assay for SARS-Cov-2 RNA from nasal and pharyngeal swabs. Delirium was diagnosed by two geriatricians according to the Diagnostic and Statistical Manual of Mental Disorders V (DMS V) criteria. The number of chronic diseases was calculated among a pre-defined list of 60. The pre-disease Clinical Frailty Scale (CFS) was assessed at hospital admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the total sample, 39 patients died, 49 were discharged and 3 were transferred to ICU. Twenty-five patients (27.5%) had delirium. Seventy-two percent of patients with delirium died during hospitalization compared to 31.8% of those without delirium. In a multivariate logistic regression model adjusted for potential confounders, patients with delirium were four times more likely to die during hospital stay compared to those without delirium (OR\u2009=\u00a03.98;95%CI\u2009=\u20091.05\u201317.28; p\u2009=\u20090.047).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Delirium is common in older patients with COVID-19 and strongly associated with in-hospital mortality. Regardless of causation, either due to a direct effect of SARS-COV-2 on the CNS or to a multifactorial cause, delirium should be interpreted as an alarming prognostic indicator in older people.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afaa189","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T19:18:09Z","timestamp":1597691889000},"page":"923-926","source":"Crossref","is-referenced-by-count":70,"title":["The impact of delirium on outcomes for older adults hospitalised with COVID-19"],"prefix":"10.1093","volume":"49","author":[{"given":"Alessandra","family":"Marengoni","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Sciences , University of Brescia,","place":["Italy"]},{"name":"Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zucchelli","sequence":"additional","affiliation":[{"name":"Department of Information Engineering , University of Brescia,","place":["Italy"]},{"name":"Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Grande","sequence":"additional","affiliation":[{"name":"Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fratiglioni","sequence":"additional","affiliation":[{"name":"Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-9629","authenticated-orcid":false,"given":"Debora","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"2024103012494074300_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa094","article-title":"Delirium: a missing piece in the COVID-19 pandemic puzzle","author":"O'Hanlon","year":"2020  6","journal-title":"Age Ageing"},{"key":"2024103012494074300_ref2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly 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