{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:51:12Z","timestamp":1782377472567,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>post hoc analysis of the international, multicentre, \u2018real-world\u2019 HOPE COVID-19 registry. All patients aged \u226565\u00a0years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65\u201374 and \u226575\u00a0years, was performed. The primary endpoint was all cause in-hospital mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>about, 1,520 patients aged \u226565\u00a0years (60.3% male, median age of 76 [IQR 71\u201383] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI\/ARBs. Patients aged 75\u00a0years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P &amp;lt; 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age \u226575 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8.06), peripheral oxygen saturation at admission &amp;lt;92% (OR 5.85), severe lymphopenia (&amp;lt;500\/mm3) (OR 3.36) and qSOFA (Quick Sequential Organ Failure Assessment Score) &amp;gt;1 (OR 8.31) to be independent predictors of mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>patients aged \u226565\u00a0years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75\u00a0years or older. Age \u226575\u00a0years, dementia, peripheral oxygen saturation &amp;lt;92%, severe lymphopenia and qSOFA scale &amp;gt;1 were independent predictors of mortality in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afaa258","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:11:02Z","timestamp":1605298262000},"page":"326-334","source":"Crossref","is-referenced-by-count":84,"title":["Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19"],"prefix":"10.1093","volume":"50","author":[{"given":"V\u00edctor Manuel","family":"Becerra-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica \u00c1rea del Coraz\u00f3n , Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), , Universidad de M\u00e1laga (UMA), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), M\u00e1laga,","place":["Spain"]},{"name":"Hospital Universitario Virgen de la Victoria , Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), , Universidad de M\u00e1laga (UMA), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), M\u00e1laga,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n J","family":"N\u00fa\u00f1ez-Gil","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel 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, Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Macaya","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Estrada","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"G\u00f3mez-Doblas","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica \u00c1rea del Coraz\u00f3n , Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), , Universidad de M\u00e1laga (UMA), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), M\u00e1laga,","place":["Spain"]},{"name":"Hospital Universitario Virgen de la Victoria , Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), , Universidad de M\u00e1laga (UMA), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), M\u00e1laga,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2024103013093220300_ref1","volume-title":"WHO announces COVID-19 outbreak a pandemic 11-03-2020","author":"World Health Organization","year":"2020"},{"key":"2024103013093220300_ref2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/ageing\/afaa093","article-title":"COVID-19 in older people: 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