{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:11:16Z","timestamp":1791886276601,"version":"4.3.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["G0601022"],"award-info":[{"award-number":["G0601022"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute hospitalisation and delirium have individually been shown to adversely affect trajectories of cognitive decline but have not previously been considered together. This work aimed to explore the impact on cognition of hospital admission with and without delirium, compared to a control group with no hospital admissions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Delirium and Cognitive Impact in Dementia (DECIDE) study was nested within the Cognitive Function and Ageing Study II (CFAS II)\u2013Newcastle cohort. CFAS II participants completed two baseline interviews, including the Mini-Mental State Examination (MMSE). During 2016, surviving participants from CFAS II\u2013Newcastle were recruited to DECIDE on admission to hospital. Participants were reviewed daily to determine delirium status.<\/jats:p>\n                  <jats:p>During 2017, all DECIDE participants and age, sex and years of education matched controls without hospital admissions during 2016 were invited to repeat the CFAS II interview. Delirium was excluded in the control group using the Informant Assessment of Geriatric Delirium Scale (i-AGeD). Linear mixed effects modelling determined predictors of cognitive decline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During 2016, 82 of 205 (40%) DECIDE participants had at least one episode of delirium. At 1 year, 135 of 205 hospitalised participants completed an interview along with 100 controls. No controls experienced delirium (i-AGeD&amp;gt;4). Delirium was associated with a faster rate of cognitive decline compared to those without delirium (\u03b2\u2009=\u2009\u22122.2, P\u2009&amp;lt;\u20090.001), but number of hospital admissions was not (P\u2009=\u20090.447).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results suggest that delirium during hospitalisation rather than hospitalisation per se is a risk factor for future cognitive decline, emphasising the need for dementia prevention studies that focus on delirium intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afab068","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T19:07:22Z","timestamp":1618168042000},"page":"1675-1681","source":"Crossref","is-referenced-by-count":12,"title":["Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people\u2014results from a nested, longitudinal cohort study"],"prefix":"10.1093","volume":"50","author":[{"given":"Sarah J","family":"Richardson","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"},{"name":"NIHR Newcastle Biomedical Research Centre, Faculty of Medical Sciences, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Lawson","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H J","family":"Davis","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health and Ageing at UCL, London WC1E 7HB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blossom C M","family":"Stephan","sequence":"additional","affiliation":[{"name":"Institute of Mental Health, Division of Psychiatry and Applied Psychology, School of Medicine, Nottingham University, Nottingham NG7 2TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Robinson","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-2388","authenticated-orcid":false,"given":"Fiona E","family":"Matthews","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Brayne","sequence":"additional","affiliation":[{"name":"Cambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda E","family":"Barnes","sequence":"additional","affiliation":[{"name":"Cambridge Public Health, University of Cambridge, Cambridge CB2 0SR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Taylor","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"},{"name":"NIHR Newcastle Biomedical Research Centre, Faculty of Medical Sciences, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G","family":"Parker","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M","family":"Allan","sequence":"additional","affiliation":[{"name":"Centre for Research in Ageing and Cognitive Health, University of Exeter, Exeter EX1 2LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"2021091315214236900_ref1","doi-asserted-by":"crossref","first-page":"e690","DOI":"10.1212\/WNL.0000000000006918","article-title":"Cognitive decline after elective and nonelective hospitalizations in older adults","volume":"92","author":"James","year":"2019","journal-title":"Neurology"},{"key":"2021091315214236900_ref2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/jgs.16909","article-title":"Association of 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