{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:13Z","timestamp":1790630533859,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical Research Future Fund"},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Initial orthostatic hypotension (OH) is a clinical syndrome of exaggerated transient orthostasis associated with higher risks of falls, frailty and syncope in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide a prevalence estimate of initial OH in adults aged 65\u00a0years or older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature search of MEDLINE (from 1946), Embase (from 1947) and Cochrane Central Register of Controlled Trials was performed until 6 December 2019, using the terms \u2018initial orthostatic hypotension\u2019, \u2018postural hypotension\u2019 and \u2018older adults\u2019. Articles were included if published in English and participants were 65\u00a0years or older. Random effects models were used for pooled analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 5,136 articles screened, 13 articles (10 cross-sectional; 3 longitudinal) reporting data of 5,465 individuals (54.5% female) from the general (n\u2009=\u20094,157), geriatric outpatient (n\u2009=\u20091,136), institutionalised (n\u2009=\u200955) and mixed (n\u2009=\u2009117) population were included. Blood pressure was measured continuously and intermittently in 11 and 2 studies, respectively. Pooled prevalence of continuously measured initial OH was 29.0% (95% CI: 22.1\u201336.9%, I2\u00a0=\u200994.6%); 27.8% in the general population (95% CI: 17.9\u201340.5%, I2\u00a0=\u200996.1%), 35.2% in geriatric outpatients (95% CI: 24.2\u201348.1%, I2\u00a0=\u200995.3%), 10.0% in institutionalised individuals (95% CI: 2.4\u201333.1%, I2\u00a0=\u20090%) and 21.4% in the mixed population (95% CI: 7.0\u201349.6, I2\u00a0=\u20090%). Pooled prevalence of intermittently measured initial OH was 5.6% (95% CI: 1.5\u201318.9%, I2\u00a0=\u200981.1%); 1.0% in the general population (95% CI: 0.0\u201323.9%, I2\u00a0=\u20090%) and 7.7% in geriatric outpatients (95% CI: 1.8\u201327.0%, I2\u00a0=\u200986.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of initial OH is high in older adults, especially in geriatric outpatients. Proper assessment of initial OH requires continuous blood pressure measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afab090","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T07:08:19Z","timestamp":1619852899000},"page":"1520-1528","source":"Crossref","is-referenced-by-count":34,"title":["Prevalence of initial orthostatic hypotension in older adults: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"50","author":[{"given":"Jennifer","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Hillebrand","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel G M","family":"Meskers","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca K","family":"Iseli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia"},{"name":"Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Healthy Longevity Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"2021091315224055900_ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"2021091315224055900_ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijcard.2018.05.043","article-title":"Initial orthostatic hypotension among patients with unexplained syncope: an overlooked 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