{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:58:58Z","timestamp":1783947538531,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG048785"],"award-info":[{"award-number":["P30AG048785"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG031679"],"award-info":[{"award-number":["P30AG031679"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG060227"],"award-info":[{"award-number":["R21AG060227"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062713"],"award-info":[{"award-number":["R01AG062713"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG056368"],"award-info":[{"award-number":["R01AG056368"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2020IF0001"],"award-info":[{"award-number":["2020IF0001"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Multicomponent interventions improve physical function and frailty in older adults, but their long-term benefit remains uncertain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective non-randomised study was conducted in 383 older Koreans (mean age, 76.8\u00a0years; female 72.3%) who were living alone or receiving medical aid. Of these, 187 individuals chose to receive a 24-week intervention that consisted of group exercise, nutritional supplements, depression management, deprescribing and home hazard reduction. The remaining 196 individuals received usual care. We compared the short physical performance battery (SPPB) score (0\u201312 points), frailty phenotype scale (0\u20135 points) and deficit-accumulation frailty index (0\u20131) at baseline, 6, 18 and 30\u00a0months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After 1:1 propensity score matching (n\u2009=\u2009117 per group), the mean SPPB scores for the intervention and comparison groups were 7.6 versus 7.6 at baseline, 10.7 versus 7.1 at 6\u00a0months (mean difference, 3.5; 95% confidence interval [CI], 2.8\u20134.2), 9.1 versus 7.8 at 18\u00a0months (1.3; 95% CI, 0.6\u20132.0) and 8.6 versus 7.5 at 30\u00a0months (1.1; 95% CI, 0.4\u20131.8). The intervention group had lower frailty phenotype scale (1.1 versus 1.8; difference, \u22120.7; 95% CI \u22121.0 to \u22120.3) and frailty index (0.22 versus 0.27; difference, \u22120.04; \u22120.06 to \u22120.02) at 6\u00a0months, but similar scores at 18 and 30\u00a0months. The 30-month mean institutionalisation-free survival time was 28.5\u00a0months in the intervention group versus 23.3\u00a0months in the comparison group (difference, 5.2\u00a0months; 95% CI, 3.1\u20137.4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The 24-week multicomponent intervention showed sustained improvement in physical function, temporary reduction in frailty and longer institutionalisation-free survival over 30\u00a0months.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afab149","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:18:40Z","timestamp":1624447120000},"page":"2157-2166","source":"Crossref","is-referenced-by-count":43,"title":["Long-term effect of a 24-week multicomponent intervention on physical performance and frailty in community-dwelling older adults"],"prefix":"10.1093","volume":"50","author":[{"given":"Gahee","family":"Oh","sequence":"first","affiliation":[{"name":"Marcus Institute for Aging Research, Hebrew Senior Life, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heayon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"},{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"},{"name":"Harvard T.H.Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunju","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"},{"name":"PyeongChang Health Center and County Hospital, PyeongChang, Gangwon-Do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Marcus Institute for Aging Research, Hebrew Senior Life, Boston, MA, USA"},{"name":"Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"2021111107294271500_ref1","volume-title":"World Health Statistics 2018: Monitoring Health for the SDGs, Sustainable Development Goals","author":"World Health 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