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This type of MI was relatively unknown among clinicians until the third universal definition of MI was published in 2017, differentiating Type 2 from Type 1 MI, which follows an acute atherothrombotic event. The pathogenesis, diagnostic and therapeutic aspects of Type 2 MI are described in the present review. Type 2 MI is a condition that is strongly linked to age because of vascular ageing concerning both epicardic vessels and microcirculation, age-related atherosclerosis and stress maladaptation. This condition predominantly affects multimorbid individuals with a history of cardiovascular disease. However, the conditions that lead to the functional imbalance between oxygen supply and demand are frequently extra-cardiac (e.g. pneumonia or anaemia). The great heterogeneity of the underlying etiological factors requires a comprehensive approach that is tailored to each case. In the absence of evidence for the benefit of invasive reperfusion strategies, the treatment of Type 2 MI remains to date essentially based on the restoration of the balance between oxygen supply and demand. For older co-morbid patients with Type 2 MI, geriatricians and cardiologists need to work together to optimise etiological investigations, treatment and prevention of predisposing conditions and precipitating factors.<\/jats:p>","DOI":"10.1093\/ageing\/afac085","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T16:18:05Z","timestamp":1647533885000},"source":"Crossref","is-referenced-by-count":13,"title":["New horizons in Type 2 myocardial infarction: pathogenesis, assessment and management of an emerging geriatric disease"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-554X","authenticated-orcid":false,"given":"Alain","family":"Putot","sequence":"first","affiliation":[{"name":"Unit\u00e9 Post Urgence G\u00e9riatrique, Centre Hospitalier Universitaire Sud R\u00e9union, 97410 Saint Pierre, France"},{"name":"Laboratoire Physiopathologie et Epid\u00e9miologie C\u00e9r\u00e9bro-Cardiovasculaire \u2013 EA7460, Universit\u00e9 de Bourgogne Franche Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Putot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Post Urgence G\u00e9riatrique, Centre Hospitalier Universitaire Sud R\u00e9union, 97410 Saint Pierre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chagu\u00e9","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Dijon Bourgogne, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Centre Hospitalier Universitaire Dijon Bourgogne, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Zeller","sequence":"additional","affiliation":[{"name":"Laboratoire Physiopathologie et Epid\u00e9miologie 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