{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:55:32Z","timestamp":1792083332789,"version":"4.4.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood pressure regulation is an automatic, moment-by-moment buffering of the blood pressure in response to physiological changes such as orthostasis, exercise and haemorrhage. This finely orchestrated reflex is called the baroreflex. It is a regulated arc of afferent, central and efferent arms. Multiple physiological changes occur with ageing that can disrupt this reflex, making blood pressure regulation less effective. In addition, multiple changes can occur with ageing-related diseases such as neurodegeneration, atherosclerosis, deconditioning and polypharmacy. These changes commonly result in orthostatic hypotension, hypertension or both, and are consistently associated with multiple adverse outcomes. In this article, we discuss the healthy baroreflex, and physiological and pathophysiological reasons for impaired baroreflex function in older people. We discuss why the common clinical manifestations of orthostatic hypotension and concomitant supine hypertension occur, and strategies for balancing these conflicting priorities. Finally, we discuss strategies for treating them, outlining our practice alongside consensus and expert guidance.<\/jats:p>","DOI":"10.1093\/ageing\/afac150","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T14:39:01Z","timestamp":1659710341000},"source":"Crossref","is-referenced-by-count":23,"title":["New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension"],"prefix":"10.1093","volume":"51","author":[{"given":"Melanie","family":"Dani","sequence":"first","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"},{"name":"Cutrale Peri-operative and Ageing group, Department of Bioengineering, Imperial College London , London W12 0BZ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Taraborrelli","sequence":"additional","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Panagopoulos","sequence":"additional","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Torocastro","sequence":"additional","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sutton","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phang Boon","family":"Lim","sequence":"additional","affiliation":[{"name":"Imperial Syncope Unit, Imperial College Healthcare NHS Trust , London W12 0HS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"2022120614325636600_ref1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/ajem.2002.34964","article-title":"Prevalence of orthostatic hypotension among patients presenting with syncope in the ED","volume":"20","author":"Sarasin","year":"2002","journal-title":"Am J Emerg Med"},{"key":"2022120614325636600_ref2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00415-016-8375-x","article-title":"The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension","volume":"264","author":"Gibbons","year":"2017","journal-title":"J 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