{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:56:48Z","timestamp":1793314608112,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Many older people with orthostatic hypotension (OH) may not report typical symptoms of dizziness, light-headedness or unsteadiness. However, the relationships between OH and falls in the absence of typical symptoms are not yet established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Continuous orthostatic blood pressure (BP) was measured during active stand using a Finometer at Wave 1 of The Irish Longitudinal Study on Ageing in participants aged\u2009\u2265\u200970\u00a0years.<\/jats:p>\n                  <jats:p>OH, with and without dizziness, was defined as a sustained drop in systolic BP\u2009\u2265\u200920 and\/or diastolic BP\u2009\u2265\u200910\u00a0mm Hg at 30, 60 and 90\u00a0seconds post-standing.<\/jats:p>\n                  <jats:p>The association between symptoms of dizziness and orthostatic BP was assessed with multi-level mixed-effects linear regression; logistic regression models assessed the longitudinal relationship between OH and falls at 6-year follow-up (Waves 2\u20135).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Almost 11% (n\u2009=\u2009934, mean age 75\u00a0years, 51% female) had OH, two-thirds of whom were asymptomatic.<\/jats:p>\n                  <jats:p>Dizziness was not associated with systolic BP drop at 30 (\u03b2\u2009=\u20091.54 (\u22121.27, 4.36); p\u2009=\u20090.256), 60 (\u03b2\u2009=\u20092.64 (\u22120.19, 5.47); p\u2009=\u20090.476) or 90\u00a0seconds (\u03b2\u2009=\u20092.02 (\u22120.91, 4.95); p\u2009=\u20090.176) after standing in adjusted models.<\/jats:p>\n                  <jats:p>Asymptomatic OH was independently associated with unexplained falls (odds ratio 2.01 [1.11, 3.65]; p\u2009=\u20090.022) but not explained falls (OR 0.93 [0.53, 1.62]; p\u2009=\u20090.797) during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Two-thirds of older people with OH did not report typical symptoms of light-headedness. Dizziness or unsteadiness after standing did not correlate with the degree of orthostatic BP drop or recovery. Participants with asymptomatic OH had a significantly higher risk of unexplained falls during follow-up, and this has important clinical implications for the assessment of older people with falls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afac295","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T16:49:18Z","timestamp":1672073358000},"source":"Crossref","is-referenced-by-count":30,"title":["Asymptomatic orthostatic hypotension and risk of falls in community-dwelling older people"],"prefix":"10.1093","volume":"51","author":[{"given":"Paul","family":"Claffey","sequence":"first","affiliation":[{"name":"Trinity College Dublin The Irish Longitudinal Study on Ageing, , Dublin, Ireland"},{"name":"St James\u2019s Hospital Mercer\u2019s Institute for Successful Ageing, , Dublin, Ireland"},{"name":"Trinity College Dublin Discipline of Medical Gerontology, , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"P\u00e9rez-Denia","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital Mercer\u2019s Institute for Successful Ageing, , Dublin, Ireland"},{"name":"Trinity College Dublin Discipline of Medical Gerontology, , Dublin, Ireland"},{"name":"St James\u2019s Hospital Department of Medical Physics and Bioengineering, , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lavan","sequence":"additional","affiliation":[{"name":"Trinity College Dublin The Irish Longitudinal Study on Ageing, , Dublin, Ireland"},{"name":"St James\u2019s Hospital Mercer\u2019s Institute for Successful Ageing, , Dublin, Ireland"},{"name":"Trinity College Dublin Discipline of Medical Gerontology, , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"Trinity College Dublin The Irish Longitudinal Study on Ageing, , Dublin, Ireland"},{"name":"St James\u2019s Hospital Mercer\u2019s Institute for Successful Ageing, , Dublin, Ireland"},{"name":"Trinity College Dublin Discipline of Medical Gerontology, , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciar\u00e1n","family":"Finucane","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital Mercer\u2019s Institute for Successful Ageing, , Dublin, Ireland"},{"name":"Trinity College Dublin Discipline of Medical Gerontology, , Dublin, Ireland"},{"name":"St James\u2019s Hospital Department of Medical Physics and Bioengineering, , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-2692","authenticated-orcid":false,"given":"Robert","family":"Briggs","sequence":"additional","affiliation":[{"name":"Trinity College Dublin The Irish Longitudinal Study on Ageing, , Dublin, Ireland"},{"name":"St 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