{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:31Z","timestamp":1792226551577,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Young Elite Scientists Sponsorship Program by China Association for Science and Technology","award":["YESS20210143"],"award-info":[{"award-number":["YESS20210143"]}]},{"name":"Major International (Regional) Joint Research Project","award":["81820108027"],"award-info":[{"award-number":["81820108027"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2006300"],"award-info":[{"award-number":["2020YFC2006300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2006300"],"award-info":[{"award-number":["2020YFC2006300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>longitudinal evidence concerning frailty phenotype and the risk of cardiovascular disease (CVD) remained insufficient, and whether CVD preventive strategies exert low CVD risk on frail adults is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>we aimed to prospectively evaluate the association of frailty phenotype, adherence to ideal cardiovascular health (CVH) and their joint associations with the risk of CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>a total of 314,093 participants from the UK Biobank were included. Frailty phenotype was assessed according to the five criteria of Fried et\u00a0al.: weight loss, exhaustion, low physical activity, slow gait speed and low grip strength. CVH included four core health behaviours (smoking, physical activity and diet) and three health factors (weight, cholesterol, blood pressure and glycaemic control). The outcome of interest was incident CVD, including coronary heart disease, heart failure and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>compared with the non-frail people whose incident rate of overall CVD was 6.54 per 1,000 person-years, the absolute rate difference per 1,000 person-years was 1.67 (95% confidence interval, CI: 1.33, 2.02) for pre-frail and 5.00 (95% CI: 4.03, 5.97) for frail. The ideal CVH was significantly associated with a lower risk of all CVD outcomes. For the joint association of frailty and CVH level with incident CVD, the highest risk was observed among frailty accompanied by poor CVH with an HR of 2.92 (95% CI: 2.68, 3.18).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>our findings indicate that physical frailty is associated with CVD incidence. Improving CVH was significantly associated with a considerable decrease in CVD risk, and such cardiovascular benefits remain for the frailty population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afac311","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T10:33:53Z","timestamp":1670409233000},"source":"Crossref","is-referenced-by-count":69,"title":["Physical frailty, adherence to ideal cardiovascular health and risk of cardiovascular disease: a prospective cohort study"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-4236","authenticated-orcid":false,"given":"Liangkai","family":"Chen","sequence":"first","affiliation":[{"name":"Huazhong University of Science and Technology Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, , Wuhan 430030, China"},{"name":"Huazhong University of Science and Technology Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingbang","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan University of Science and Technology Congenital Heart Disease Center, Wuhan Asia Heart Hospital, , Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Lv","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, , Wuhan 430030 , China"},{"name":"Huazhong University of Science and Technology Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Uppsala University Department of Neuroscience, , Uppsala 75185 , Sweden"},{"name":"Karolinska Institute Department of Clinical Neuroscience, , Stockholm 17165 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine Department of Epidemiology, School of Public Health, , Shanghai 200025 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Rong","sequence":"additional","affiliation":[{"name":"Wuhan University of Science and Technology Department of Nutrition and Food Hygiene, School of Public Health, Medical College, , Wuhan 430065 , 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