{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:06:00Z","timestamp":1791021960672,"version":"4.1.0"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Katthy Taylor Chair in Vascular Dementia at the University of Calgary"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gait impairment contributes to falls and frailty. Some studies suggest that cerebral small vessel disease (CSVD) is associated with gait impairment in the general population. We systematically reviewed and meta-analysed the literature on associations of CSVD with gait impairment and falls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The protocol was published in PROSPERO (CRD42021246009). Searches of Medline, Cochrane and Embase databases were conducted on 30 March 2022. Cross-sectional and longitudinal studies of community-dwelling adults were included, reporting relationships between diagnosis or neuroimaging markers of CSVD and outcomes related to gait or falls. Partial correlation coefficients were calculated and pooled using a random-effects model for meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search retrieved 73 studies (53 cross-sectional; 20 longitudinal). Most studies reported an association between CSVD and gait impairments or falls risk: 7\/7 studies on CSVD score or diagnosis, 53\/67 studies on white matter hyperintensities (WMHs), 11\/21 studies on lacunar infarcts, 6\/15 studies on cerebral microbleeds and 1\/5 studies on perivascular spaces. Meta-analysis of 13 studies found that higher WMH volume was mildly correlated with lower gait speed, in all studies (r\u2009=\u2009\u22120.23, 95% confidence interval: \u22120.33 to \u22120.14, P\u2009&amp;lt;\u20090.0001). However, there was significant heterogeneity between studies (I2\u2009=\u200982.95%; tau2 = 0.02; Q\u2009=\u200979.37, P\u2009&amp;lt;\u20090.0001), which was unexplained by variation in age, sex, study quality or if the study adjusted for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings suggest that CSVD severity is associated with gait impairment, history of falls and risk of future falls. Prevention of CSVD should be part of a comprehensive public health strategy to improve mobility and reduce risk of falls in later life.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ageing\/afad011","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T13:32:09Z","timestamp":1680269529000},"source":"Crossref","is-referenced-by-count":70,"title":["Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-9664","authenticated-orcid":false,"given":"Breni","family":"Sharma","sequence":"first","affiliation":[{"name":"Cumming School of Medicine, University of Calgary , Calgary, AB , Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Community Health Sciences, University of Calgary , Calgary, AB , Canada"},{"name":"O'Brien Institute of Public Health, University of Calgary , Calgary, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl R","family":"McCreary","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada"},{"name":"Seaman Family MR Research Centre, University of Calgary , Calgary, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology), University of Alberta , Edmonton, AB , Canada"},{"name":"Neuroscience and Mental Health Institute, University of Alberta , Edmonton, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E","family":"Smith","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary , Calgary, AB , Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada"},{"name":"Department of Community Health Sciences, University of Calgary , Calgary, AB , Canada"},{"name":"Seaman Family MR Research Centre, University of Calgary , Calgary, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"2023033114194281600_","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small 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