{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:32:33Z","timestamp":1785461553890,"version":"3.56.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ASPREE","award":["U01AG029824"],"award-info":[{"award-number":["U01AG029824"]}]},{"name":"ASPREE","award":["U19AG062682"],"award-info":[{"award-number":["U19AG062682"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Ageing","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["334047"],"award-info":[{"award-number":["334047"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1127060"],"award-info":[{"award-number":["1127060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Monash University and the Victorian Cancer Agency"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Evidence for the prognostic implications of hyperglycaemia in older adults is inconsistent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate disability-free survival (DFS) in older individuals by glycaemic status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This analysis used data from a randomised trial recruiting 19,114 community-based participants aged \u226570\u00a0years, who had no prior cardiovascular events, dementia and physical disability. Participants with sufficient information to ascertain their baseline diabetes status were categorised as having normoglycaemia (fasting plasma glucose [FPG]\u2009&amp;lt;\u20095.6\u00a0mmol\/l, 64%), prediabetes (FPG 5.6 to &amp;lt;7.0\u00a0mmol\/l, 26%) and diabetes (self-report or FPG\u2009\u2265\u20097.0\u00a0mmol\/l or use of glucose-lowering agents, 11%). The primary outcome was loss of disability-free survival (DFS), a composite of all-cause mortality, persistent physical disability or dementia. Other outcomes included the three individual components of the DFS loss, as well as cognitive impairment-no dementia (CIND), major adverse cardiovascular events (MACE) and any cardiovascular event. Cox models were used for outcome analyses, with covariate adjustment using inverse-probability weighting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 18,816 participants (median follow-up: 6.9 years). Compared to normoglycaemia, participants with diabetes had greater risks of DFS loss (weighted HR: 1.39, 95% CI 1.21\u20131.60), all-cause mortality (1.45, 1.23\u20131.72), persistent physical disability (1.73, 1.35\u20132.22), CIND (1.22, 1.08\u20131.38), MACE (1.30, 1.04\u20131.63) and cardiovascular events (1.25, 1.02\u20131.54) but not dementia (1.13, 0.87\u20131.47). The prediabetes group did not have an excess risk for DFS loss (1.02, 0.93\u20131.12) or other outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among older people, diabetes was associated with reduced DFS, and higher risk of CIND and cardiovascular outcomes, whereas prediabetes was not. The impact of preventing or treating diabetes in this age group deserves closer attention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afad060","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T15:44:41Z","timestamp":1682437481000},"source":"Crossref","is-referenced-by-count":4,"title":["Prediabetes, diabetes and loss of disability-free survival in a community-based older cohort: a post-hoc analysis of the ASPirin in Reducing Events in the Elderly trial"],"prefix":"10.1093","volume":"52","author":[{"given":"Zhen","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"},{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, TAS , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J","family":"Curtis","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Owen","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine Hennepin HealthCare, Berman Centre for Outcomes and Clinical Research, Hennepin Healthcare Research Institute , Minneapolis, MN , USA"},{"name":"University of Minnesota , Minneapolis, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Tonkin","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, College of Pharmacy, The University of Iowa , Iowa, IA , USA"},{"name":"Department of Family Medicine, Carver College of Medicine, The University of Iowa , Iowa, IA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne G","family":"Orchard","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prudence R","family":"Carr","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University , Perth, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Sam and Ann Barshop Institute, UT Health San Antonio , San Antonio, TX , USA"},{"name":"Geriatrics Research, South Texas Veterans Health Care System , San Antonio, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj C","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, The Rush Alzheimer\u2019s Disease Center, Rush University Medical Center , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"McNeil","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Nelson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, TAS , 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