{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:18:15Z","timestamp":1790029095501,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ludwig-Maximilians-University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>while many drug groups are associated with falls in older people, less is known about absolute increases in risk and how these risks vary across different groups of drugs or individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method and Design<\/jats:title>\n                  <jats:p>we conducted a population based nested case\u2013control study among people aged \u226565\u00a0years in the Scottish regions of Tayside and Fife. Cases were individuals hospitalised with a fracture between 2010 and 2020, to whom we matched up to 10 controls. We examined relative and absolute risks of drug groups known as \u2018Fall-Risk-Increasing Drugs\u2019 (FRIDs), alone and in combination, and among younger and older (\u226575\u00a0years) adults. Adjusting for previous hospitalisations, drug use and laboratory data, we used conditional logistic regression to quantify associations between drug exposures and outcomes. We conducted four sensitivity analyses to test the robustness of our findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>the cohort comprised 246,535 people aged \u226565\u00a0years, of whom 18,456 suffered an incident fracture. Fracture risks were significantly increased for most FRIDs examined. Absolute risks were much larger among older vs younger people and both relative and absolute risks increased with the number of FRIDs combined. Overall, the highest absolute increase in risk were found in people aged \u226575\u00a0years for selective serotonin reuptake inhibitors (number needed to harm 53), tricyclic antidepressants (NNH 81), antipsychotics (NNH 75) and use of three or more FRIDs (NNH \u226466).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>patients aged \u226575\u00a0years prescribed antidepressants or antipsychotics or taking three or more drugs that increase risk of falls may benefit most from deprescribing interventions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afad079","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T14:46:18Z","timestamp":1685630778000},"source":"Crossref","is-referenced-by-count":18,"title":["Single and combined use of fall-risk-increasing drugs and fracture risk: a population-based case\u2013control study"],"prefix":"10.1093","volume":"52","author":[{"given":"Jonathan","family":"Hauff","sequence":"first","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Rottenkolber","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Oehler","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fischer","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Gensichen","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Drey","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health Center for Drug Safety and Effectiveness, , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Caleb","family":"Alexander","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"},{"name":"Johns Hopkins Bloomberg School of Public Health Center for Drug Safety and Effectiveness, , Baltimore, MD , USA"},{"name":"Johns Hopkins Bloomberg School of Public Health Department of Epidemiology, , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Guthrie","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig-Maximilians-Universit\u00e4t Munich Department of Medicine IV, Geriatrics, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Dreischulte","sequence":"additional","affiliation":[{"name":"University Hospital of Ludwig-Maximilians-University Munich Institute of General Practice and Family Medicine, , Munich 80336 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2023071913234459000_ref1","doi-asserted-by":"crossref","first-page":"e018836","DOI":"10.1136\/bmjopen-2017-018836","article-title":"Incidence and mortality of fractures by frailty level over 80 years of age: cohort study using UK electronic health records","volume":"8","author":"Ravindrarajah","year":"2018","journal-title":"BMJ Open"},{"key":"2023071913234459000_ref2","doi-asserted-by":"crossref","first-page":"e12509","DOI":"10.1111\/ecc.12509","article-title":"A comprehensive geriatric assessment screening questionnaire (CGA-GOLD) for older people undergoing treatment for cancer","volume":"26","author":"Whittle","year":"2017","journal-title":"Eur J Cancer Care"},{"key":"2023071913234459000_ref3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.15585\/mmwr.mm6927a5","article-title":"Trends in nonfatal falls and fall-related injuries among adults aged \u226565 years - 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