{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:42:32Z","timestamp":1791394952129,"version":"4.3.3"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Project for Sanqin Academic Innovation Team in Shaanxi Province","award":["SQ0157"],"award-info":[{"award-number":["SQ0157"]}]},{"name":"Shaanxi Provincial Traditional Chinese Medicine Administration"},{"name":"Middle Youth Research and Innovation Team Project","award":["2022-SLRH-LJ-007"],"award-info":[{"award-number":["2022-SLRH-LJ-007"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["XZY012022136"],"award-info":[{"award-number":["XZY012022136"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>observational studies have indicated that gut microbiome dysbiosis was associated with Alzheimer\u2019s disease (ad). However, the results are largely inconsistent and it remains unknown whether the association is causal in nature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>leveraging observational studies and genome-wide association studies (GWAS) on the gut microbiome in ad patients, we pooled the microbiome data (N\u00a0=\u20091,109) to screen the microbiota significantly altered in ad patients and then conducted Mendelian randomisation (MR) study to determine the causal associations between altered microbiota (N\u00a0=\u200918,340) and ad using two different ad GWAS datasets (N\u00a0=\u200963,926 and N\u00a0=\u2009472,868) using the inverse variance-weighted (IVW) method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>the combined effect sizes from observational studies showed that 8 phyla, 18 classes, 22 orders, 37 families, 78 genera and 109 species significantly changed in ad patients. Using the MR analysis, we found that two classes, one order, one family and one genus were suggestively associated with ad consistently in two different GWAS datasets. Both observational studies and MR analysis simultaneously showed that Desulfovibrionales (order) and Desulfovibrionaceae (family), which were mainly implicated in dissimilatory sulfate reduction, were significantly associated with an elevated risk of ad.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>our findings demonstrated that the abundance of sulfate-reducing bacteria was increased in ad patients, which was causally linked to an increased risk of ad. Further efforts are warranted to clarify the underlying mechanisms, which will provide new insight into the prevention and treatment of ad.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afad112","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T14:56:16Z","timestamp":1689778576000},"source":"Crossref","is-referenced-by-count":13,"title":["Integration of genome-wide association studies (GWAS) and microbiome data highlights the impact of sulfate-reducing bacteria on Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"52","author":[{"given":"Xingzhi","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Geriatric Neurology, Shaanxi Provincial People\u2019s Hospital , Xi\u2019an, Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Shaanxi Provincial Clinical Research Center for Geriatric Medicine , Xi\u2019an Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Institute of Medical Research, Northwestern Polytechnical University , Xi'an Shaanxi 710072 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Shaanxi Provincial People\u2019s Hospital , Xi\u2019an, Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Shaanxi Provincial Clinical Research Center for Geriatric Medicine , Xi\u2019an Shaanxi 710068 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Shaanxi Provincial People\u2019s Hospital , Xi\u2019an, Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Shaanxi Provincial Clinical Research Center for Geriatric Medicine , Xi\u2019an Shaanxi 710068 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Shaanxi Provincial People\u2019s Hospital , Xi\u2019an, Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Shaanxi Provincial Clinical Research Center for Geriatric Medicine , Xi\u2019an Shaanxi 710068 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-9232","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Shaanxi Provincial People\u2019s Hospital , Xi\u2019an, Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Shaanxi Provincial Clinical Research Center for Geriatric Medicine , Xi\u2019an Shaanxi 710068 , People\u2019s Republic of China"},{"name":"Institute of Medical Research, Northwestern Polytechnical University , Xi'an Shaanxi 710072 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"2023073110010520800_ref1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(21)00066-1","article-title":"Clinical diagnosis of Alzheimer's disease: recommendations of the international working group","volume":"20","author":"Dubois","year":"2021","journal-title":"Lancet Neurol"},{"key":"2023073110010520800_ref2","doi-asserted-by":"crossref","first-page":"101580","DOI":"10.1016\/j.eclinm.2022.101580","article-title":"Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: a value of statistical life approach","volume":"51","author":"Nandi","year":"2022","journal-title":"EClinicalMedicine"},{"key":"2023073110010520800_ref3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41591-021-01369-8","article-title":"A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease","volume":"27","author":"Salloway","year":"2021","journal-title":"Nat Med"},{"key":"2023073110010520800_ref4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"2023073110010520800_ref5","doi-asserted-by":"crossref","first-page":"e2728","DOI":"10.1002\/brb3.2728","article-title":"Is Alzheimer's disease an infectious neurological disease? 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