{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:53:01Z","timestamp":1792464781988,"version":"4.5.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Caisse Nationale pour la Solidarit\u00e9 et l\u2019Autonomie"},{"DOI":"10.13039\/501100007494","name":"Fondation Plan Alzheimer","doi-asserted-by":"publisher","award":["FCS 2009\u201312"],"award-info":[{"award-number":["FCS 2009\u201312"]}],"id":[{"id":"10.13039\/501100007494","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French National Research Agency COGINUT","award":["ANR-06-PNRA-005"],"award-info":[{"award-number":["ANR-06-PNRA-005"]}]},{"name":"Ministry of Research-INSERM Programme \u201cCohortes et collections de donn\u00e9es biologiques\u201d"},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Governments of Aquitaine and Bourgogne"},{"name":"Institut de la Long\u00e9vit\u00e9"},{"name":"Mutuelle G\u00e9n\u00e9rale de l\u2019Education Nationale"},{"name":"Direction G\u00e9n\u00e9rale de la Sant\u00e9"},{"name":"Caisse Nationale Maladie des Travailleurs Salari\u00e9s"},{"DOI":"10.13039\/501100002915","name":"The Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French National Research Agency (ANR) \u2018Programme d\u2019Investissement d\u2019Avenir\u2019"},{"name":"Urban Mental Health Program of the University of Amsterdam"},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer Nederland and the NWO Food & Cognition Program"},{"DOI":"10.13039\/501100003413","name":"BMWFW","doi-asserted-by":"publisher","award":["BMWFW-10.420\/0009-WF\/V\/3c\/2015"],"award-info":[{"award-number":["BMWFW-10.420\/0009-WF\/V\/3c\/2015"]}],"id":[{"id":"10.13039\/501100003413","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICREA 2018 Academia Award from the Generalitat de Catalunya"},{"name":"FEDER Program from EU","award":["2017SGR1546"],"award-info":[{"award-number":["2017SGR1546"]}]},{"DOI":"10.13039\/501100003329","name":"MINECO","doi-asserted-by":"publisher","award":["PCIN-2015-229"],"award-info":[{"award-number":["PCIN-2015-229"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-15-HDHL-0002-05"],"award-info":[{"award-number":["ANR-15-HDHL-0002-05"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","award":["MR\/N030087\/1"],"award-info":[{"award-number":["MR\/N030087\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013279","name":"JPI-HDHL","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could represent a neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and\/or individual nutrients (e.g., vitamin D, omega 3) can modify HN, but also modify risk for CD, dementia, and depression. Therefore, the interaction between diet\/nutrition and HN may alter risk trajectories for these ageing-related brain conditions. Using a subsample (n\u00a0=\u2009371) of the Three-City cohort\u2014where older adults provided information on diet and blood biobanking at baseline and were assessed for CD, dementia, and depressive symptomatology across 12\u00a0years\u2014we tested for interactions between food consumption, nutrient intake, and nutritional biomarker concentrations and neurogenesis-centred susceptibility status (defined by baseline readouts of hippocampal progenitor cell integrity, cell death, and differentiation) on CD, Alzheimer\u2019s disease (AD), vascular and other dementias (VoD), and depressive symptomatology, using multivariable-adjusted logistic regression models. Increased plasma lycopene concentrations (OR [95% CI] \u2009= \u20091.07 [1.01, 1.14]), higher red meat (OR [95% CI]\u2009 =\u2009 1.10 [1.03, 1.19]), and lower poultry consumption (OR [95% CI]\u2009 = \u20090.93 [0.87, 0.99]) were associated with an increased risk for AD in individuals with a neurogenesis-centred susceptibility. Increased vitamin D consumption (OR [95% CI]\u2009 =\u2009 1.05 [1.01, 1.11]) and plasma \u03b3-tocopherol concentrations (OR [95% CI]\u2009 =\u2009 1.08 [1.01, 1.18]) were associated with increased risk for VoD and depressive symptomatology, respectively, but only in susceptible individuals. This research highlights an important role for diet\/nutrition in modifying dementia and depression risk in individuals with a neurogenesis-centred susceptibility.<\/jats:p>","DOI":"10.1093\/ageing\/afae042","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T07:40:10Z","timestamp":1715758810000},"page":"ii47-ii59","source":"Crossref","is-referenced-by-count":18,"title":["Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing"],"prefix":"10.1093","volume":"53","author":[{"given":"Andrea","family":"Du Preez","sequence":"first","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London Department of Basic and Clinical Neuroscience, , London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lef\u00e8vre-Arbogast","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Gonz\u00e1lez-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"University of Barcelona Nutrition, Food Science and Gastronomy Department, Faculty of Pharmacy and Food Science, , 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) , Instituto de Salud Carlos III, 0828 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki","family":"Houghton","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London Department of Basic and Clinical Neuroscience, , London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"de Lucia","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London Department of Basic and Clinical Neuroscience, , London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunah","family":"Lee","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London Department of Basic and Clinical Neuroscience, , London SE5 9NU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorrain Y","family":"Low","sequence":"additional","affiliation":[{"name":"UMR1019, Universit\u00e9 Clermont Auvergne INRA, Human Nutrition Unit, , F-63000 Clermont Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Helmer","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"F\u00e9art","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delcourt","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Proust-Lima","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Pall\u00e0s","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Food Sciences, and Institute of Neurosciences, University of Barcelona Pharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, , E-08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"S\u00e1nchez-Pla","sequence":"additional","affiliation":[{"name":"University of Barcelona Nutrition, Food Science and Gastronomy Department, Faculty of Pharmacy and Food Science, , 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) , Instituto de Salud Carlos III, 0828 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Urpi-Sard\u00e0","sequence":"additional","affiliation":[{"name":"University of Barcelona Nutrition, Food Science and Gastronomy Department, Faculty of Pharmacy and Food Science, , 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) , Instituto de Salud Carlos III, 0828 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvie R","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam Brain Plasticity Group, , 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Altendorfer","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, , Salzburg 5020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Aigner","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, , Salzburg 5020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Lucassen","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam Brain Plasticity Group, , 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Korosi","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam Brain Plasticity Group, , 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Manach","sequence":"additional","affiliation":[{"name":"UMR1019, Universit\u00e9 Clermont Auvergne INRA, Human Nutrition Unit, , F-63000 Clermont Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Andres-Lacueva","sequence":"additional","affiliation":[{"name":"University of Barcelona Nutrition, Food Science and Gastronomy Department, Faculty of Pharmacy and Food Science, , 08028 Barcelona, Spain"},{"name":"CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) , Instituto de Salud Carlos III, 0828 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cilia","family":"Samieri","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219 , F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-8083","authenticated-orcid":false,"given":"Sandrine","family":"Thuret","sequence":"additional","affiliation":[{"name":"Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London Department of Basic and Clinical Neuroscience, , London SE5 9NU, UK"},{"name":"University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden Department of Neurology, , 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024051506115664800_ref1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41380-018-0098-1","article-title":"Brain age and other bodily \u2018ages\u2019: implications for neuropsychiatry","volume":"24","author":"Cole","year":"2019","journal-title":"Mol Psychiatry"},{"key":"2024051506115664800_ref2","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The world report on ageing and health: a policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"key":"2024051506115664800_ref3","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1017\/S0144686X21001070","article-title":"The perspectives of successful ageing among older adults aged 75+: a systematic review with a narrative synthesis of mixed studies","volume":"43","author":"Badache","year":"2023","journal-title":"Ageing Soc"},{"key":"2024051506115664800_ref4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"2024051506115664800_ref5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2023.01.002","article-title":"Adult hippocampal neurogenesis in Alzheimer\u2019s disease: a roadmap to clinical relevance","volume":"30","author":"Salta","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2024051506115664800_ref6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainresbull.2022.07.009","article-title":"Neuromodulation and hippocampal neurogenesis in depression: a scoping review","volume":"188","author":"Flores","year":"2022","journal-title":"Brain Res Bull"},{"key":"2024051506115664800_ref7","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020286","article-title":"Implication of adult hippocampal neurogenesis in Alzheimer\u2019s disease and potential therapeutic approaches","volume":"11","author":"Essa","year":"2022","journal-title":"Cells"},{"key":"2024051506115664800_ref8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.molmed.2020.03.010","article-title":"Adult hippocampal neurogenesis in major depressive disorder and Alzheimer\u2019s disease","volume":"26","author":"Berger","year":"2020","journal-title":"Trends Mol Med"},{"key":"2024051506115664800_ref9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/alz.12428","article-title":"The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia","volume":"18","author":"Du Preez","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2024051506115664800_ref10","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1038\/s41380-022-01644-1","article-title":"Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study","volume":"27","author":"Du Preez","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2024051506115664800_ref11","doi-asserted-by":"crossref","first-page":"104022","DOI":"10.1016\/j.archger.2020.104022","article-title":"Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults","volume":"88","author":"Vicinanza","year":"2020","journal-title":"Arch Gerontol Geriatr"},{"key":"2024051506115664800_ref12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exger.2018.05.012","article-title":"Mediterranean diet and depression among older individuals: the multinational MEDIS study","volume":"110","author":"Masana","year":"2018","journal-title":"Exp Gerontol"},{"key":"2024051506115664800_ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mnfr.201900177","article-title":"Diet-related metabolites associated with cognitive decline revealed by untargeted metabolomics in a prospective cohort","volume":"63","author":"Low","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"2024051506115664800_ref14","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial","volume":"84","author":"Mart\u00ednez-Lapiscina","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024051506115664800_ref15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3945\/ajcn.112.051276","article-title":"Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County study on memory, health and aging","volume":"98","author":"Wengreen","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"2024051506115664800_ref16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12263-009-0134-5","article-title":"Impact of diet on adult hippocampal neurogenesis","volume":"4","author":"Stangl","year":"2009","journal-title":"Genes Nutr"},{"key":"2024051506115664800_ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/563160","article-title":"Effects of diet on brain plasticity in animal and human studies: mind the gap","volume":"2014","author":"Murphy","year":"2014","journal-title":"Neural Plast"},{"key":"2024051506115664800_ref18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000072920","article-title":"Vascular factors and risk of dementia: design of the Three-City study and baseline characteristics of the study population","volume":"22","year":"2003","journal-title":"Neuroepidemiology"},{"key":"2024051506115664800_ref19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1017\/S0007114507812050","article-title":"Macronutrient intake and discrepancy with nutritional recommendations in a group of elderly diabetic subjects","volume":"99","author":"Helmer","year":"2008","journal-title":"Br J Nutr"},{"key":"2024051506115664800_ref20","first-page":"497","article-title":"Sociodemographic differences in dietary habits in a population-based sample of elderly subjects: the 3C study","volume":"8","author":"Larrieu","year":"2004","journal-title":"J Nutr Health Aging"},{"key":"2024051506115664800_ref21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1017\/S0007114507756520","article-title":"Energy, macronutrient and fatty acid intake of French elderly community dwellers and association with socio-demographic characteristics: data from the Bordeaux sample of the Three-City study","volume":"98","author":"F\u00e9art","year":"2007","journal-title":"Br J Nutr"},{"key":"2024051506115664800_ref22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/gerona\/glv135","article-title":"Plasma carotenoids are inversely associated with dementia risk in an elderly French cohort","volume":"71","author":"Feart","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2024051506115664800_ref23","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/ajcn\/88.3.714","article-title":"Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk","volume":"88","author":"Samieri","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2024051506115664800_ref24","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jalz.2017.03.003","article-title":"Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer\u2019s disease in older adults","volume":"13","author":"Feart","year":"2017","journal-title":"Alzheimers Dement"},{"key":"2024051506115664800_ref25","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1001\/jama.1994.03520100096046","article-title":"DSM-IV: diagnostic and statistical manual of mental disorders","volume":"272","author":"Bell","year":"1994","journal-title":"JAMA"},{"key":"2024051506115664800_ref26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Measur"},{"key":"2024051506115664800_ref27","first-page":"385","article-title":"The CES-D scale: A self-report depression scale for research in the general population","volume-title":"Applied Psychological Measurement","author":"Radloff","year":"1977"},{"key":"2024051506115664800_ref28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/13607863.2019.1566434","article-title":"Latent structure of the Centre for Epidemiologic Studies Depression Scale (CES-D) in older adult populations: a systematic review","volume":"24","author":"Cosco","year":"2020","journal-title":"Aging Ment Health"},{"key":"2024051506115664800_ref29","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"2024051506115664800_ref30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jalz.2015.05.016","article-title":"Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective","volume":"11","author":"Baumgart","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2024051506115664800_ref31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12916-020-01873-7","article-title":"Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews","volume":"19","author":"Mentis","year":"2021","journal-title":"BMC Med"},{"key":"2024051506115664800_ref32","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17207475","article-title":"Association of Late Life Depression, (non-) modifiable risk and protective factors with dementia and Alzheimer\u2019s disease: literature review on current evidences, preventive interventions and possible future trends in prevention and treatment of dementia","volume":"17","author":"Kuo","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"2024051506115664800_ref33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/HRP.0000000000000240","article-title":"Late-life depression: a narrative review on risk factors and prevention","volume":"28","author":"Vyas","year":"2020","journal-title":"Harv Rev Psychiatry"},{"key":"2024051506115664800_ref34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/ajcn\/nqab028","article-title":"Meat consumption and risk of incident dementia: cohort study of 493,888 UK biobank participants","volume":"114","author":"Zhang","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"2024051506115664800_ref35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3233\/JAD-130719","article-title":"Trends in diet and Alzheimer\u2019s disease during the nutrition transition in Japan and developing countries","volume":"38","author":"Grant","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2024051506115664800_ref36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3945\/ajcn.2009.27580","article-title":"Dietary fish and meat intake and dementia in Latin America, China, and India: a 10\/66 dementia research group population-based study12","volume":"90","author":"Albanese","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"2024051506115664800_ref37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12916-023-02772-3","article-title":"Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK biobank prospective cohort study","volume":"21","author":"Shannon","year":"2023","journal-title":"BMC Med"},{"key":"2024051506115664800_ref38","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s12603-021-1675-6","article-title":"Mediterranean diet in healthy aging","volume":"25","author":"Mazza","year":"2021","journal-title":"J Nutr Health Aging"},{"key":"2024051506115664800_ref39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/nu12010035","article-title":"The Mediterranean diet slows down the progression of aging and helps to prevent the onset of frailty: a narrative review","volume":"12","author":"Capurso","year":"2019","journal-title":"Nutrients"},{"key":"2024051506115664800_ref40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054491","article-title":"Influence of the Mediterranean diet on healthy aging","volume":"24","author":"Andreo-L\u00f3pez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024051506115664800_ref41","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41430-020-00841-x","article-title":"Mediterranean diet and the hallmarks of ageing","volume":"75","author":"Shannon","year":"2021","journal-title":"Eur J Clin Nutr"},{"key":"2024051506115664800_ref42","doi-asserted-by":"crossref","first-page":"112065","DOI":"10.1016\/j.exger.2022.112065","article-title":"Mediterranean diet and structural neuroimaging biomarkers of Alzheimer\u2019s and cerebrovascular disease: a systematic review","volume":"172","author":"Gregory","year":"2023","journal-title":"Exp Gerontol"},{"key":"2024051506115664800_ref43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/BST20220762","article-title":"The impact of amino acid metabolism on adult neurogenesis","volume":"51","author":"Guo","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"2024051506115664800_ref44","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fneur.2018.00710","article-title":"Sarcopenia and muscle functions at various stages of Alzheimer disease","volume":"9","author":"Ogawa","year":"2018","journal-title":"Front Neurol"},{"key":"2024051506115664800_ref45","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1001\/archneurol.2009.240","article-title":"Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons","volume":"66","author":"Boyle","year":"2009","journal-title":"Arch Neurol"},{"key":"2024051506115664800_ref46","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1093\/eurheartj\/ehad336","article-title":"Red meat consumption, cardiovascular diseases, and diabetes: a systematic review and meta-analysis","volume":"44","author":"Shi","year":"2023","journal-title":"Eur Heart J"},{"key":"2024051506115664800_ref47","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1080\/10408398.2021.1975092","article-title":"Association of poultry consumption with cardiovascular diseases and all-cause mortality: a systematic review and dose response meta-analysis of prospective cohort studies","volume":"63","author":"Papp","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2024051506115664800_ref48","doi-asserted-by":"crossref","DOI":"10.3389\/fepid.2023.1095236","article-title":"Cardiovascular disease, associated risk factors, and risk of dementia: an umbrella review of meta-analyses","volume":"3","author":"Brain","year":"2023","journal-title":"Front Epidemiol"},{"key":"2024051506115664800_ref49","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061370","article-title":"Effects of high-fat and high-fat high-sugar diets in the anxiety, learning and memory, and in the hippocampus neurogenesis and neuroinflammation of aged rats","volume":"15","author":"Mota","year":"2023","journal-title":"Nutrients"},{"key":"2024051506115664800_ref50","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194137","article-title":"Feeding the brain: effect of nutrients on cognition, synaptic function, and AMPA receptors","volume":"14","author":"Fad\u00f3","year":"2022","journal-title":"Nutrients"},{"key":"2024051506115664800_ref51","doi-asserted-by":"crossref","first-page":"1147269","DOI":"10.3389\/fnins.2023.1147269","article-title":"Nutrition and adult neurogenesis in the hippocampus: does what you eat help you remember?","volume":"17","author":"Melgar-Locatelli","year":"2023","journal-title":"Front Neurosci"},{"key":"2024051506115664800_ref52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1179\/1476830513Y.0000000092","article-title":"Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms","volume":"17","author":"Freeman","year":"2014","journal-title":"Nutr Neurosci"},{"key":"2024051506115664800_ref53","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat Med"},{"key":"2024051506115664800_ref54","article-title":"The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer\u2019s disease: therapeutic implications and future perspectives","volume":"11","author":"Jurc\u0103u","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"2024051506115664800_ref55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbi.2016.09.001","article-title":"Myocardial ischemia\/reperfusion impairs neurogenesis and hippocampal-dependent learning and memory","volume":"61","author":"Evonuk","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2024051506115664800_ref56","first-page":"e1281862","article-title":"Diabetes, adult neurogenesis and brain remodeling: new insights from rodent and zebrafish models","volume":"4","author":"Dorsemans","year":"2017","journal-title":"Neurogenes (Austin, Tex)"},{"key":"2024051506115664800_ref57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.irn.2020.03.020","article-title":"Harnessing neurogenesis in the adult brain-a role in type 2 diabetes mellitus and Alzheimer\u2019s disease","volume":"155","author":"Lazarov","year":"2020","journal-title":"Int Rev Neurobiol"},{"key":"2024051506115664800_ref58","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000356486","article-title":"Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer\u2019s disease mortality in older adults","volume":"37","author":"Min","year":"2013","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2024051506115664800_ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-220460","article-title":"Low Xanthophylls, retinol, lycopene, and tocopherols in gey and white matter of brains with Alzheimer\u2019s disease","volume":"94","author":"Dorey","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"2024051506115664800_ref60","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1017\/jns.2019.16","article-title":"Lycopene and cognitive function","volume":"8","author":"Crowe-White","year":"2019","journal-title":"J Nutr Sci"},{"key":"2024051506115664800_ref61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/156720510790274473","article-title":"Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI) patients are characterized by increased BDNF serum levels","volume":"7","author":"Angelucci","year":"2010","journal-title":"Curr Alzheimer Res"},{"key":"2024051506115664800_ref62","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/acn3.50956","article-title":"High-resolution metabolomic profiling of Alzheimer\u2019s disease in plasma","volume":"7","author":"Niedzwiecki","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"key":"2024051506115664800_ref63","doi-asserted-by":"crossref","first-page":"104823","DOI":"10.1016\/j.neuint.2020.104823","article-title":"Lycopene\u2014a pleiotropic neuroprotective nutraceutical: deciphering its therapeutic potentials in broad spectrum neurological disorders","volume":"140","author":"Paul","year":"2020","journal-title":"Neurochem Int"},{"key":"2024051506115664800_ref64","doi-asserted-by":"crossref","first-page":"5519330","DOI":"10.1155\/2021\/5519330","article-title":"Lycopene-loaded microemulsion regulates neurogenesis in rats with A\u03b2-induced Alzheimer\u2019s disease rats based on the Wnt\/\u03b2-catenin pathway","volume":"2021","author":"Ning","year":"2021","journal-title":"Neural Plast"},{"key":"2024051506115664800_ref65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5490218","article-title":"The secretion from neural stem cells Pretreated with lycopene protects against tert-butyl Hydroperoxide-induced neuron oxidative damage","volume":"2018","author":"Huang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"2024051506115664800_ref66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.13050","article-title":"Early compensatory responses against neuronal injury: a new therapeutic window of opportunity for Alzheimer\u2019s disease?","volume":"25","author":"Merlo","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"2024051506115664800_ref67","first-page":"14","article-title":"Association of vitamin D levels with incident all-cause dementia in longitudinal observational studies: a systematic review and meta-analysis","volume":"7","author":"Kalra","year":"2020","journal-title":"J Prev Alzheimers Dis"},{"key":"2024051506115664800_ref68","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0000000000000755","article-title":"Vitamin D and the risk of dementia and Alzheimer disease","volume":"83","author":"Littlejohns","year":"2014","journal-title":"Neurology"},{"key":"2024051506115664800_ref69","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/dad2.12404","article-title":"Vitamin D supplementation and incident dementia: effects of sex, APOE, and baseline cognitive status","volume":"15","author":"Ghahremani","year":"2023","journal-title":"Alzheimers Dement (Amst)"},{"key":"2024051506115664800_ref70","article-title":"Vitamin E, alpha-tocopherol, and its effects on depression and anxiety: a systematic review and meta-analysis","volume":"14","author":"Lee","year":"2022","journal-title":"Nutrients"},{"key":"2024051506115664800_ref71","article-title":"Associations of dietary vitamin C and E intake with depression. A meta-analysis of observational studies","volume":"9","author":"Ding","year":"2022","journal-title":"Front Nutr"},{"key":"2024051506115664800_ref72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.33137\/juls.v15i1.37312","article-title":"Role of antioxidant vitamins in neurogenesis","volume":"15","author":"Roy-Chowdhury","year":"2021","journal-title":"J Undergrad Life Sci"},{"key":"2024051506115664800_ref73","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311191","article-title":"Vitamin E and its molecular effects in experimental models of neurodegenerative diseases","volume":"24","author":"Cunha Germano","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024051506115664800_ref74","doi-asserted-by":"crossref","first-page":"e10419","DOI":"10.1002\/jbm4.10419","article-title":"Vitamin D: brain and behavior","volume":"5","author":"Eyles","year":"2021","journal-title":"JBMR Plus"},{"key":"2024051506115664800_ref75","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225243","article-title":"Important flavonoids and their role as a therapeutic agent","volume":"25","author":"Ullah","year":"2020","journal-title":"Molecules"},{"key":"2024051506115664800_ref76","doi-asserted-by":"crossref","DOI":"10.3390\/biom11121825","article-title":"Emerging role of flavonoids as the treatment of depression","volume":"11","author":"Pannu","year":"2021","journal-title":"Biomolecules"},{"key":"2024051506115664800_ref77","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archinte.1997.00440250107012","article-title":"Screening for depression in elderly primary care patients: a comparison of the Center for Epidemiologic Studies\u2014Depression Scale and the geriatric depression scale","volume":"157","author":"Lyness","year":"1997","journal-title":"Arch Intern Med"},{"key":"2024051506115664800_ref78","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1249\/00005768-199108000-00015","article-title":"A physical activity questionnaire for the elderly","volume":"23","author":"Voorrips","year":"1991","journal-title":"Med Sci Sports Exerc"},{"key":"2024051506115664800_ref79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12877-020-01538-3","article-title":"Physical activity types and risk of dementia in community-dwelling older people: the Three-City cohort","volume":"20","author":"Dupr\u00e9","year":"2020","journal-title":"BMC Geriatr"}],"container-title":["Age and Ageing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ageing\/article-pdf\/53\/Supplement_2\/ii47\/57524515\/afae042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ageing\/article-pdf\/53\/Supplement_2\/ii47\/57524515\/afae042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T14:23:04Z","timestamp":1731421384000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ageing\/article\/53\/Supplement_2\/ii47\/7668928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":79,"journal-issue":{"issue":"Supplement_2","published-print":{"date-parts":[[2024,5,11]]}},"URL":"https:\/\/doi.org\/10.1093\/ageing\/afae042","relation":{},"ISSN":["0002-0729","1468-2834"],"issn-type":[{"value":"0002-0729","type":"print"},{"value":"1468-2834","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]}}}