{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:55:44Z","timestamp":1787241344123,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Ministry of Health","award":["n\u00b013-23"],"award-info":[{"award-number":["n\u00b013-23"]}]},{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute gastrointestinal bleeding (AGIB) is common in older patients but the use of iron in this context remains understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate prospectively the efficacy of ferric carboxymaltose to treat anaemia in older patients after AGIB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomised double-blinded placebo-controlled clinical trial was conducted in 10 French centres. Eligible patients were 65\u00a0years or more, had controlled upper or lower gastrointestinal bleeding and a haemoglobin level of 9\u201311\u00a0g\/dl. Patients were randomly assigned, in a 1:1 ratio, to receive either one intravenous iron injection of ferric carboxymaltose or one injection of saline solution. The primary endpoint was the difference in haemoglobin level between day 0 and day 42. Secondary endpoints were treatment-emergent adverse events, serious adverse events, rehospitalisation and improvement of quality of life (QOL) at day 180.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From January 2013 to January 2017, 59 patients were included. The median age of patients was 81.9 [75.8, 87.3] years. At day 42, a significant difference in haemoglobin level increase was observed (2.49\u00a0g\/dl in the ferric carboxymaltose group vs. 1.56\u00a0g\/dl in the placebo group, P\u2009=\u20090.02). At day 180, QOL, measured on European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30, improved by 10.5 points in the ferric carboxymaltose group and by 8.2 points in the placebo group (P\u2009=\u20090.56). Rates of adverse events and rehospitalisation were similar in the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravenous iron seems safe and effective to treat anaemia in older patients after AGIB and should be considered as a standard-of-care treatment. ClinicalTrials.gov (NCT01690585).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afae085","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T20:04:49Z","timestamp":1713384289000},"source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of ferric carboxymaltose on haemoglobin response among older patients with gastrointestinal bleeding: a randomised clinical trial"],"prefix":"10.1093","volume":"53","author":[{"given":"Nicolas","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Univ Rouen Normandie, INSERM, ADEN UMR1073, \u201cNutrition, Inflammation and microbiota-gut-brain axis\u201d, CHU Rouen , Rouen F-76000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Arab-Hocine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Clinical Nutrition, CHU of Nice and University C\u00f4te d\u2019Azur , Nice 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Musikas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Caen University Hospital , Caen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Amil","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, La Roche Sur Yon Hospital , La Roche Sur Yon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Amiens University and Hospital , Amiens ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nahon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Le Raincy \u2013 Montfermeil Hospital - , Le Raincy, Montfermeil 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