{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:48:30Z","timestamp":1791845310701,"version":"4.3.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health Technology Assessment"},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A640323"],"award-info":[{"award-number":["N42A640323"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative cognitive dysfunction (POCD) manifests as a subtle decline in cognition, potentially leading to unfavourable postoperative outcomes. We explored the impact of POCD on physical function, length of hospital stay (LOS), dementia and mortality outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and Scopus were searched until May 2023. All studies of major surgical patients that assessed POCD and outcomes of interest were included. POCD effects were stratified by surgery type (cardiac and noncardiac) and time of POCD assessment (&amp;lt;30 and\u2009\u226530\u00a0days postsurgery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2316 studies, 20 met the inclusion criteria. POCD was not associated with functional decline postsurgery. Patients who experienced POCD postcardiac surgery had an increased relative risk (RR) of death of 2.04 [(95% CI: 1.18, 3.50); I2\u00a0=\u20090.00%]. Sensitivity analyses showed associations with intermediate-term mortality among noncardiac surgical patients, with an RR of 1.84 [(95% CI: 1.26, 2.71); I2\u00a0=\u20090.00%]. Patients who developed POCD &amp;lt;30\u00a0days postcardiac and noncardiac surgeries experienced longer LOS than those who did not [mean difference (MD)\u2009=\u20091.37\u00a0days (95% CI: 0.35, 2.39); I2\u00a0=\u200992.38% and MD\u2009=\u20091.94\u00a0days (95% CI: 0.48, 3.40); I2\u00a0=\u200983.29%, respectively]. Postoperative delirium (POD) may contribute to the heterogeneity observed, but limited data were reported within the studies included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing cardiac and noncardiac surgeries who developed POCD &amp;lt;30\u00a0days postsurgery had poorer outcomes and an increased risk of premature death. Early recognition of perioperative neurocognitive disorders in at-risk patients may enable early intervention. However, POD may confound our findings, with further studies necessary to disentangle the effects of POD from POCD on clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afae160","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T01:47:48Z","timestamp":1720921668000},"source":"Crossref","is-referenced-by-count":80,"title":["Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-6369","authenticated-orcid":false,"given":"Patumporn","family":"Suraarunsumrit","sequence":"first","affiliation":[{"name":"Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University , Bangkok , Thailand"},{"name":"Division of Geriatric Medicine , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Siriraj Health Policy Unit , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varalak","family":"Srinonprasert","sequence":"additional","affiliation":[{"name":"Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University , Bangkok , Thailand"},{"name":"Division of Geriatric Medicine , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Siriraj Health Policy Unit , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanawan","family":"Kongmalai","sequence":"additional","affiliation":[{"name":"Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University , Bangkok , Thailand"},{"name":"Siriraj Health Policy Unit , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Division of Endocrinology and Metabolism , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Department of Medicine, Faculty of Medicine Siriraj Hospital, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surasit","family":"Suratewat","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yanhee Hospital , Bangkok 10700 , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usa","family":"Chaikledkaew","sequence":"additional","affiliation":[{"name":"Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University , Bangkok , Thailand"},{"name":"Social Administrative Pharmacy Division , Department of Pharmacy, Faculty of Pharmacy, , Bangkok , Thailand"},{"name":"Mahidol University , Department of Pharmacy, Faculty of Pharmacy, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasivimol","family":"Rattanasiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics , Faculty of Medicine Ramathibodi Hospital, , Bangkok , Thailand"},{"name":"Mahidol University , Faculty of Medicine Ramathibodi Hospital, , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"McKay","sequence":"additional","affiliation":[{"name":"Centre for Public 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