{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:06Z","timestamp":1791229566400,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC2001900"],"award-info":[{"award-number":["2018YFC2001900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2022-4-5025"],"award-info":[{"award-number":["2022-4-5025"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171464"],"award-info":[{"award-number":["82171464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171180"],"award-info":[{"award-number":["82171180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371469"],"award-info":[{"award-number":["82371469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Postoperative cognitive impairment are common neural complications in older surgical patients and exacerbate the burden of medical care on families and society.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 140 older patients who were scheduled for elective orthopaedic surgery or pancreatic surgery with general anaesthesia were randomly assigned to Group S or Group I with a 1:1 allocation. Patients in Group S and Group I received intranasal administration of 400\u00a0\u03bcL of normal saline or 40\u00a0IU\/400\u00a0\u03bcL of insulin, respectively, once daily from 5\u00a0minutes before anaesthesia induction until 3\u00a0days postoperatively. Perioperative cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment-Basic (MoCA-B) at 1\u00a0day before and 3\u00a0days after surgery and postoperative delirium (POD) incidence was assessed using the 3-minute Diagnostic Interview for CAM (3D-CAM) on postoperative days 1\u20133. Serum levels of interleukin-6 (IL-6), tumour necrosis factor \u03b1 (TNF-\u03b1), S100-\u03b2 and C-reactive protein (CRP) were measured on the first day after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Insulin treatment significantly increased postoperative MMSE and MoCA-B scores in group I than in group S (P\u2009&amp;lt;\u20090.001, P\u2009=\u20090.001, respectively), decreased the incidence of POD within the 3-day postoperative period in Group I than in Group S (10.9% vs 26.6%, P\u2009=\u20090.024), and inhibited postoperative IL-6 and S100-\u03b2 levels in Group I compared to Group S (P\u2009=\u20090.034, P\u2009=\u20090.044, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Intranasal insulin administration is thus suggested as a potential therapy to improve postoperative cognition in older patients undergoing surgery. However, a more standardized multi-centre, large-sample study is needed to further validate these results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afae188","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T21:19:34Z","timestamp":1725139174000},"source":"Crossref","is-referenced-by-count":28,"title":["Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial"],"prefix":"10.1093","volume":"53","author":[{"given":"Miao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital , Beijing 100730,","place":["China"]},{"name":"Department of Anesthesiology , The First Affiliated Hospital, , Jinzhou, Liaoning Province,","place":["China"]},{"name":"Jinzhou Medical University , The First Affiliated Hospital, , Jinzhou, Liaoning 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, Beijing,","place":["China"]},{"name":"Capital Medical University , Beijing Tongren Hospital, , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital , Beijing 100730,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital , Beijing 100730,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital , Beijing 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