{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:13:05Z","timestamp":1790662385670,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The clinical relevance of blood pressure variability (BPV) is still unknown, despite increasing evidence associating BPV to negative health outcomes (NHOs). There is currently no gold standard to define high BPV and normal reference values for BPV are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The primary aim was to examine whether high BPV can predict NHO in adults aged \u226565. The predictive value of BPV was compared to mean BP (mBP) when both parameters were available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PubMed and Web of Science were systematically screened; 49 articles (12 retrospective, 18 prospective and 19 cross-sectional studies) were included and evaluated for methodological quality. Meta-analyses were conducted to examine the association of BPV (and mBP when available) with NHO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Systolic BPV and systolic mBP seem to indicate at least comparable odds for cardiovascular disease (BPV: odds ratio (OR)\u2009=\u20091.33 (95% CI: 1.19\u20131.48, P\u2009&amp;lt;\u2009.00001) vs mBP: OR\u2009=\u20091.06 (95% CI: 1.03\u20131.09, P\u2009=\u2009.0002)) and cerebral deterioration (BPV: OR\u2009=\u20091.28 (95% CI: 1.17\u20131.41, P\u2009&amp;lt;\u2009.00001) vs mBP: OR\u2009=\u20091.06 (95% CI: 1.04\u20131.09, P\u2009&amp;lt;\u2009.00001)). Increased diastolic BPV was associated with higher odds of cerebral deterioration (OR\u2009=\u20091.18 (95% CI: 1.04\u20131.35), P\u2009=\u2009.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>High systolic BPV and high systolic mBP are associated with 33% and 6% higher odds of cardiovascular disease in adults aged \u226565, respectively. High BPV is also related to an 18%\u201328% and 11% increased odds of cerebral deterioration and poor stroke recovery. An overview of cut-off values is provided for the most often reported BPV parameters in literature, which can be used as a guideline to identify elevated BPV in clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afae262","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T10:33:43Z","timestamp":1732876423000},"source":"Crossref","is-referenced-by-count":8,"title":["Elevated blood pressure variability is associated with an increased risk of negative health outcomes in adults aged 65 and above\u2014a systematic review and meta-analysis"],"prefix":"10.1093","volume":"53","author":[{"given":"Jordy","family":"Saren","sequence":"first","affiliation":[{"name":"Gerontology Department, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Debain","sequence":"additional","affiliation":[{"name":"Gerontology Department, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]},{"name":"Frailty & Resilience in Ageing (FRIA) Research Unit, Vitality Research Group, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]},{"name":"Geriatrics Department, Universitair Ziekenhuis Brussel (UZ Brussel) , Laarbeeklaan 101, 1090 Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fien","family":"Loosveldt","sequence":"additional","affiliation":[{"name":"Gerontology Department, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-8646","authenticated-orcid":false,"given":"Mirko","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Section of Geriatrics, Department of Internal Medicine and Paediatrics, Ghent University , Corneel Heymanslaan 10, 9000 Ghent ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-9586","authenticated-orcid":false,"given":"Ivan","family":"Bautmans","sequence":"additional","affiliation":[{"name":"Gerontology Department, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]},{"name":"Frailty & Resilience in Ageing (FRIA) Research Unit, Vitality Research Group, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 103, 1090 Brussels ,","place":["Belgium"]},{"name":"Geriatrics Department, Universitair Ziekenhuis Brussel (UZ Brussel) , Laarbeeklaan 101, 1090 Brussels ,","place":["Belgium"]},{"name":"Geriatric Physiotherapy Department, SOMT University of Physiotherapy , Softwareweg 5, 3821 BN Amersfoort ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"2024112910333339900_ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.53.1.96","article-title":"Blood pressure and heart rate variabilities in normotensive and hypertensive human beings","volume":"53","author":"Mancia","year":"1983","journal-title":"Circ Res"},{"key":"2024112910333339900_ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrcardio.2013.1","article-title":"Assessment and management of blood-pressure variability","volume":"10","author":"Parati","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"2024112910333339900_ref3","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.jacc.2019.02.063","article-title":"Risk factor variability and cardiovascular outcome: JACC review topic of the week","volume":"73","author":"Messerli","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2024112910333339900_ref4","first-page":"527","article-title":"Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - 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