{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:12:21Z","timestamp":1787008341049,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate if frailty status alters following solid organ transplantation (lung, liver, kidney and heart) without rehabilitation intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research design and methods<\/jats:title>\n                    <jats:p>Studies published between 1 January 2000 and 30 May 2023 were searched across five databases. Studies measuring frailty, using a validated or established frailty measure, pre- and post-transplant were included. Narrative synthesis was used to describe the included studies according to the time post-transplant and according to solid organ group. Where data allowed a meta-analysis was conducted to compare frailty prevalence pre- and 6\u201312\u00a0months post-transplant across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies were included in this review (6 kidney transplant, 2 liver transplant, 3 lung transplant and 1 heart transplant), with a total of 3065 transplant recipients with 62% being male. The mean age across studies was 51.35\u00a0years old. When narratively synthesised after an initial worsening of frailty immediately post-transplant, there appears to be a significant improvement in frailty by 3\u00a0months post-transplant that is sustained by 6 to 12\u00a0months following solid organ transplantation. Five studies were included in the meta-analysis which demonstrated an odds ratio\u2009=\u20090.27 (95% CI, 0.12, 0.59, P\u00a0=\u2009.001, ${I}^2$\u00a0=\u200982%) for frailty prevalence post-solid organ transplantation (SOT) compared to frailty prevalence pre-SOT. When the single paper deemed to be of poor quality was removed the remaining four studies demonstrated a reduced odds ratio of being frail at 6\u201312\u00a0months post-transplant (OR 0.45 (95% CI, 0.32, 0.65, P\u2009=\u2009.001, ${I}^2$\u00a0=\u200913%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transplant may be associated with a reversal in frailty, although heterogeneity was demonstrated across studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afae283","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T15:12:45Z","timestamp":1735744365000},"source":"Crossref","is-referenced-by-count":7,"title":["Change in frailty status in the 12\u00a0months following solid organ transplantation: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"54","author":[{"given":"Anna","family":"Bevan","sequence":"first","affiliation":[{"name":"Centre for Medical Education, Heath Park, Cardiff University , CF14 4YS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Avery","sequence":"additional","affiliation":[{"name":"Centre for Medical Education, Heath Park, Cardiff University , CF14 4YS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoe Leong","family":"Cheah","sequence":"additional","affiliation":[{"name":"Centre for Medical Education, Heath Park, Cardiff University , CF14 4YS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-8865","authenticated-orcid":false,"given":"Ben","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, De Crespigny Park , SE5 8AF, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-1792","authenticated-orcid":false,"given":"Jonathan","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Heath Park, Cardiff University , CF14 4YS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025040209320199700_ref1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.21037\/atm.2018.09.68","article-title":"Solid organ transplantation in the 21(st) century","volume":"6","author":"Black","year":"2018","journal-title":"Ann Transl Med"},{"key":"2025040209320199700_ref2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"2025040209320199700_ref3","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2025040209320199700_ref4","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/ajt.15198","article-title":"Report from the American Society of Transplantation on frailty in solid organ transplantation","volume":"19","author":"Kobashigawa","year":"2019","journal-title":"Am J Transplant"},{"key":"2025040209320199700_ref5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1681\/ASN.2018070726","article-title":"Frailty and changes in cognitive function after kidney transplantation","volume":"30","author":"Chu","year":"2019","journal-title":"J Am Soc 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