{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:51:07Z","timestamp":1785783067308,"version":"3.56.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hospitalisation often results in adverse effects in older adults, particularly an increased risk of functional and cognitive decline. Although in-hospital exercise interventions have shown benefits, their impact on intrinsic capacity (IC) remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the effects of multicomponent exercise training on IC in acutely hospitalised older adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Pooled analysis of two randomised clinical trials.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Three Acute Care for Elders units.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>Hospitalised older adults (\u226575\u00a0years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The control group received standard care, whereas the exercise group participated in an in-hospital multicomponent exercise program. The primary outcome was IC assessed using a composite score (0\u2013100) across five domains: vitality (handgrip strength), cognition (Mini-Mental State Examination), psychological health (Yesavage Geriatric Depression Scale), locomotion (Short Physical Performance Battery) and sensory function (self-reported vision and hearing). Adverse outcomes were evaluated 1\u00a0year after discharge, including emergency visits, hospital re-admission and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 570 patients (age 87.3\u2009\u00b1\u20094.8\u00a0years) were enrolled during acute hospitalisation [median duration 8 (interquartile range\u2009=\u20093) days] and randomised to the exercise (n\u2009=\u2009288) or control group (n\u2009=\u2009282). The exercise intervention significantly improved IC compared to the control group [7.74 points, 95% confidence interval (CI) 6.45\u20139.03, P\u2009&amp;lt;\u2009.001], with benefits observed in all IC domains. IC score at discharge was inversely associated with mortality risk during follow-up (OR\u2009=\u20090.98 per each increase in IC score at discharge, 95% CI\u2009=\u20090.96, 0.99, P\u2009=\u2009.010), although no association was found with emergency visits (P\u2009=\u2009.866) or re-admissions (P\u2009=\u2009.567).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In-hospital exercise is an effective strategy to enhance IC in hospitalised older adults. Additionally, the IC score at discharge was inversely related to the mortality risk within 1\u00a0year of discharge.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afaf082","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:49:20Z","timestamp":1742726960000},"source":"Crossref","is-referenced-by-count":8,"title":["Exercise effects on intrinsic capacity in acutely hospitalised older adults: a pooled analysis of two randomised controlled trials"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-3369","authenticated-orcid":false,"given":"Pedro L","family":"Valenzuela","sequence":"first","affiliation":[{"name":"University of Alcal\u00e1 - Systems Biology Department , Ctra. 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,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-9960","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Martinez-Velilla","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad P\u00fablica de Navarra (UPNA), IdiSNA , Pamplona, Navarra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-9827","authenticated-orcid":false,"given":"Fabricio","family":"Zambom-Ferraresi","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad P\u00fablica de Navarra (UPNA), IdiSNA , Pamplona, Navarra ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-9485","authenticated-orcid":false,"given":"Eduardo Lusa","family":"Cadore","sequence":"additional","affiliation":[{"name":"Exercise Research Laboratory, School of Physical Education Physiotherapy and Dance, Universidade Federal do Rio Grande do Sul , Porto Alegre,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-6960","authenticated-orcid":false,"given":"Robinson","family":"Ram\u00edrez-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad P\u00fablica de 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