{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:23:07Z","timestamp":1788992587322,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Japanese Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["22KK0269"],"award-info":[{"award-number":["22KK0269"]}]},{"name":"JSPS KAKENHI","award":["21H03283"],"award-info":[{"award-number":["21H03283"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Digital gait biomarkers (DGBs) from wrist-worn devices may offer a simple, convenient method for assessing frailty; however, their clinical validity has not been sufficiently verified. This study aimed to determine whether frailty assessed using DGBs is not inferior to the Fried frailty phenotype for predicting hospitalisation and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This longitudinal study included 10\u00a0156 adults (aged 43\u201381\u00a0years) with complete Fried frailty phenotype and DGB data from the UK Biobank. DGBs were extracted using validated algorithms on raw data from wrist-worn accelerometers over 7\u00a0days. DGB frailty was derived from DGBs and the Fried frailty phenotype.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>First hospitalisations and deaths were followed for 4.4\u2009\u00b1\u20092.7 and 7.2\u2009\u00b1\u20090.7\u00a0years, respectively. In these periods, 6148 (60.5%) were hospitalised (44\u00a0277 person-years follow-up) and 270 (2.7%) died (73\u00a0312 person-years follow-up). Cox proportional hazards models, adjusting for confounders, showed that both Fried and DGB frailties were predictive of hospitalisation (hazard ratios and 95% confidence intervals [CIs]: 1.29 [1.13\u20131.47] versus 1.33 [1.17\u20131.52]) and mortality (1.63 [1.01\u20132.62] versus 1.77 [1.14\u20132.74]). The mean differences (DGB frailty\u2013Fried frailty) and 95% CIs in Harrell\u2019s C-index for hospitalisation and mortality were 0.000 [\u22120.002 to 0.001] and 0.002 [\u22120.004 to 0.009], respectively, with the lower limit of the 95% CIs exceeding the prespecified noninferiority margin (\u22120.1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>DGB-derived frailty predicted hospitalisation and mortality and was not inferior to the Fried frailty phenotype. These findings support the clinical validity and potential utility of wearable devices in the assessment of frailty in clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afaf210","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T13:32:06Z","timestamp":1754055126000},"source":"Crossref","is-referenced-by-count":4,"title":["Frailty assessed by a wrist-worn device can predict hospitalisation and mortality in middle-aged and older adults: a UK Biobank study"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5744-1961","authenticated-orcid":false,"given":"Yosuke","family":"Osuka","sequence":"first","affiliation":[{"name":"Department of Frailty Research, Center for Geriatrics and Social Science, Research Institute, National Center for Geriatrics and Gerontology , Obu, Aichi ,","place":["Japan"]},{"name":"Falls, Balance and Injury Research Center, Neuroscience Research Australia , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-950X","authenticated-orcid":false,"given":"Lloyd L Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Center, Neuroscience Research Australia , Sydney, New South Wales ,","place":["Australia"]},{"name":"School of Health Sciences, University of New South Wales , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-3458","authenticated-orcid":false,"given":"Matthew","family":"Brodie","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering, University of New South Wales , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-0230","authenticated-orcid":false,"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Center, Neuroscience Research Australia , Sydney, New South Wales ,","place":["Australia"]},{"name":"School of Population Health, University of New South Wales , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-8802","authenticated-orcid":false,"given":"Stephen R","family":"Lord","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Center, Neuroscience Research Australia , Sydney, New South Wales ,","place":["Australia"]},{"name":"School of Population Health, University of New South Wales , Sydney, New South Wales 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