{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:43:42Z","timestamp":1780382622194,"version":"3.54.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We examined whether anticholinergic overactive bladder (OAB) medications are associated with emergency hospital admissions with delirium in adults without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>England\u2019s primary care linked to inpatient records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The source population comprised 215\u00a0293 adults initiating anticholinergic OAB medications (e.g. oxybutynin, solifenacin and tolterodine) during July 2010\u2013December 2019 when aged \u226550\u00a0years, without dementia, severe mental illness or &amp;lt;12\u00a0months registration. We conducted self-controlled case-series including 1831 men and 1954 women with emergency hospital admissions with delirium. Incidence rate ratios (IRR) were estimated in risk periods during 6\u00a0months before and 12\u00a0months after initiating OAB medications, adjusted for time-varying age, separately in men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The risk of delirium admissions was elevated for the first 1\u201330\u00a0days of prescriptions [IRR 1.54 (95% CI 1.30\u20131.82) for men, 1.44 (1.22\u20131.70) for women] and whilst reducing over time for women [1.10 (0.94\u20131.29) for 91\u2013365\u00a0days of prescriptions], it remained elevated for men [1.38 (1.17\u20131.64)]. There was some evidence of greater delirium IRRs in older men and men initiating higher dosages. In secondary analysis of 502 adults initiating mirabegron (non-anticholinergic beta-3 receptor agonist), the delirium IRRs during the first 1\u201330 and 31\u201390\u00a0days of prescriptions were 1.15 (0.76\u20131.75) and 0.72 (0.47\u20131.09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed increased hospital admission rates with delirium for adults without dementia whilst prescribed OAB anticholinergics, but not whilst prescribed mirabegron. Delirium risk remained raised for longer for men and was greater in older men. Alternative management options for OAB in older people should be considered before prescribing anticholinergic medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afaf308","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:37:45Z","timestamp":1759750665000},"source":"Crossref","is-referenced-by-count":2,"title":["Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-8413","authenticated-orcid":false,"given":"Kathryn","family":"Richardson","sequence":"first","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Mattishent","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oby Otu","family":"Enwo","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Steel","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge , Cambridge 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